Turmeric (Herb/Suppl)

Brand and Other Names:curcumin, curcuma longa, more...turmeric root, wild curcuma

Suggested Dosing

Extract standardized to 95% curcumin

Dyspepsia

500 mg QID PO

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Suggested Uses

Orally

Dyspepsia, abdominal pain, hemorrhage, diarrhea, flatulence, abdominal bloating, loss of appetite, jaundice, hepatitis, and liver and gallbladder complaints, headaches, bronchitis, colds, respiratory infections, fibromyalgia, leprosy, fever, amenorrhea, and cancer

Topically

Analgesia, ringworm, bruising, leech bites, eye infections, inflammatory skin conditions, inflammation of the oral mucosa, and infected wounds

Efficacy

Effective in dyspepsia; insufficient evidence for other uses including various cancers

The National Center for Complementary and Integrative Health (NCCIH) has studied curcumin for Alzheimer disease, rheumatoid arthritis, and prostate and colon cance

Claims that curcuminoids found in turmeric help to reduce inflammation are not supported by strong studies

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Interactions

Interaction Checker

and Turmeric

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (18)

                • alfentanil

                  turmeric will increase the level or effect of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • carbamazepine

                  turmeric will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • cinnamon

                  cinnamon and turmeric both increase anticoagulation. Use Caution/Monitor.

                • cyclosporine

                  turmeric will increase the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • dihydroergotamine

                  turmeric will increase the level or effect of dihydroergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • disopyramide

                  turmeric will increase the level or effect of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • ergotamine

                  turmeric will increase the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • ethosuximide

                  turmeric will increase the level or effect of ethosuximide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • everolimus

                  turmeric will increase the level or effect of everolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • fentanyl

                  turmeric will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • midazolam

                  turmeric will increase the level or effect of midazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • pacritinib

                  turmeric will increase the level or effect of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • pimozide

                  turmeric will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • quinidine

                  turmeric will increase the level or effect of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • quinine

                  turmeric will increase the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • sirolimus

                  turmeric will increase the level or effect of sirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • tacrolimus

                  turmeric will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                • triazolam

                  turmeric will increase the level or effect of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

                Minor (0)

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                  Adverse Effects

                  Frequency Not Defined

                  GI disturbances (chronic use)

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                  Warnings

                  Contraindications

                  Hypersensitivity, bile duct obstruction, gastric ulcer

                  Avoid prior to surgery: may cause bleeding

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: N/A

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Curcumin: anti-inflammatory (COX inhibition); stimulates production and release of bile; antispasmodic; hepatoprotective; antioxidant

                  Pharmacokinetics

                  Low bioavailability limits use as an oral agent

                  Hydrophobic properties make curcumin unsuitable for intravenous administration

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.