Dosing & Uses
Not indicated
Dosage Forms & Strengths
intratracheal suspension
- 80mg/mL (1.5mL or 3mL vial)
Respiratory Distress Syndrome
Indicated for rescue treatment of respiratory distress syndrome (RDS) in premature infants
It reduces mortality and pneumothoraces associated with RDS
2.5 mL/kg birth weight intratracheal, THEN may repeat up to 2 more time at 1.25 mL/kg ~q12hr in infants whom RDS is considered responsible for their persisting or deteriorating respiratory status
Maximum total dosage (sum of the initial and up to 2 repeat doses): 5 mL/kg
Adverse Effects
>10%
Patent ductus arteriosus (60%)
Intracranial hemorrhage (51%)
Pneumothorax (21%)
Pulmonary interstitial emphysema (21%)
Bronchopulmonary dysplasia (18%)
Acquired pneumonia (17%)
Acquired septicemia (14%)
Postmarketing Reports
Pulmonary hemorrhage, a known complication of premature birth and very low birth-weight, has been reported
Warnings
Contraindications
None
Cautions
Administration of exogenous surfactants can rapidly affect oxygenation and lung compliance; infants should receive frequent clinical and laboratory assessments so that oxygen and ventilatory support can be modified to respond to respiratory changes
Transient adverse reactions associated with administration include bradycardia, hypotension, endotracheal tube blockage, and oxygen desaturation
Pregnancy & Lactation
Pregnancy Category: Not applicable
Lactation: Not applicable
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Replaces deficient endogenous lung surfactant in neonates with respiratory distress syndrome
Surfactant prevents the alveoli from collapsing during expiration by lowering surface tension between alveolar surfaces and air
Administration
Preparation of suspension
Remove vial from a refrigerator and slowly warm the vial to room temperature before use
Visually inspect suspension for discoloration before use; suspension should appear white to creamy white
Discard if suspension is discolored.
Gently turn the vial upside-down, in order to obtain a uniform suspension; do not shake
Locate the notch (FLIP UP) on the colored plastic cap and lift the notch and pull upwards
Pull plastic cap with the aluminum portion downwards
Remove the whole ring by pulling off aluminum wrapper
Remove the rubber cap to extract content
Intratracheal Administration
For intratracheal administration only
Administered by, or under the supervision of clinicians experienced in intubation, ventilator management, and general care of premature infants
Before administering, assure proper placement and patency of the endotracheal tub
Allow the infant to stabilize before proceeding with dosing
Administer intratracheally by instillation in two divided aliquots through a 5 French end-hole catheter OR in a single bolus through the secondary lumen of a dual lumen endotracheal tube without interrupting mechanical ventilation
Storage
Unopened vials: Refrigerate at 2-8ºC (36-46ºF)
Protect from light
Do not shake
Vials are for single use only; discard unused portion after opening the vial
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
Curosurf intratracheal - | 120 mg/1.5 mL vial | ![]() | |
Curosurf intratracheal - | 240 mg/3 mL vial | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
poractant alfa intratracheal
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.