Dosing & Uses
Dosage Forms & Strengths
solution
- 0.5%
- 1%
- 2%
Mydriasis/Cycloplegia Diaganosis
1-2 gtt of 1% solution in eye; may repeat in 5 minutes PRN; cycloplegia & mydriasis may last for 24 hours
Use 2% in heavily pigmented iris
Overdose Management
Ocular: Flush eyes w/water
Ingestion: Emesis, lavage
Severe systemic ADR's: Physostigmine
Dosage Forms & Strengths
solution
- 0.5%
- 1%
- 2%
Mydriasis/Cycloplegia
1-2 gtt of 0.5%, 1% or 2% solution in eye; may repeat 5 minutes later by second application of 0.5% or 1% solution if necessary
Adverse Effects
Frequency Not Defined
Blurred vision
Burning sensation in eye
Light intolerance
Tachycardia
Conjunctivitis
Raised intraocular pressure
Hyperreactive response in Down's syndrome children (atropine)
Drowsiness
Warnings
Contraindications
Hypersensitivity to drug or components
Cautions
Remove contact lenses prior to administration and wait 15 min before reinserting
The elderly may be predisposed to increased intraocular pressure
Mydriatics may produce transient elevation of intraocular pressure; patients with untreated narrow-angle glaucoma or anatomically narrow angles may be susceptible to angle-closure following administration
Dropper tip is not to touch any surface, as this may contaminate the solution
A transient burning sensation may occur upon instillation
Patients should be advised not to drive or engage in other hazardous activities while pupils are dilated
Patients may experience sensitivity to light and should protect eyes in bright illumination during dilation
Parents should be warned not to get this preparation in their child's mouth and to wash their own hands and the child's hands following administration
Feeding intolerance may follow ophthalmic use of this product in infants; it is recommended that feeding be withheld for 4 hours after examination
CNS effects
- May cause central nervous system (CNS) disturbances, especially in younger age groups but may occur at any age, especially with stronger solutions
- Infants are especially prone to CNS and cardiopulmonary side effects; to minimize absorption, use only 1 drop of 0.5% solution per eye, followed by pressure applied over nasolacrimal sac for two to three minutes; observe infants closely for at least 30 minutes following instillation
Pregnancy & Lactation
Pregnancy
Animal reproduction studies have not been conducted; not known whether cyclopentolate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; administer to a pregnant woman only if clearly needed
Lactation
Not known whether this drug is excreted in human milk; because many drugs are excreted in human milk, exercise caution when drug is administered to a nursing woman
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Onset: rapid; max effect not for 30 min
Excretion: urine
Mechanism of Action
Blocks action of acetylcholine resulting in relaxation of the cholinergically innervated iris sphincter muscle
Cholinergic stimulation of accommodative ciliary muscle of lens is also blocked
Anticholinergic effects of cyclopentolate in eye produce dilation of the pupil (mydriasis) and paralysis of accommodation (cycloplegia)
Pharmacokinetics
Onset of action: 25-75 min (cycloplegia); 30-60 min (mydriasis)
Duration: < 24hr
Absorption: Minimal systemic
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Cyclogyl ophthalmic (eye) - | 2 % drops |  | |
| Cyclogyl ophthalmic (eye) - | 1 % drops |  | |
| Cyclogyl ophthalmic (eye) - | 2 % drops |  | |
| Cyclogyl ophthalmic (eye) - | 2 % drops |  | |
| Cyclogyl ophthalmic (eye) - | 0.5 % drops |  | |
| Cyclogyl ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 2 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 0.5 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 2 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 2 % drops |  | |
| cyclopentolate ophthalmic (eye) - | 1 % drops |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
cyclopentolate ophthalmic (eye)
CYCLOPENTOLATE HYDROCHLORIDE SOLUTION - OPHTHALMIC
(SYE-kloe-PEN-toe-late HYE-droe-KLOR-ide)
COMMON BRAND NAME(S): Cyclogyl
USES: This medication is used before eye examinations (such as refraction exams). It belongs to a class of drugs known as anticholinergics. Cyclopentolate works by temporarily widening (dilating) the pupil of the eye and relaxing the muscles of the eye.
HOW TO USE: This medication is usually applied in the eye 40 to 50 minutes before the procedure or as directed by your doctor. The dose may need to be repeated in 5 to 10 minutes. This medication is for use in the eye only. Do not take by mouth or inject.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. If you are wearing contact lenses, remove them before using eye drops. Ask your doctor when you can start wearing them again. If you are using another kind of eye medication (such as drops or ointments), ask your doctor when you should start using them again.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure for 2 to 3 minutes. This will prevent the medication from draining away from the eye and reduce side effects. Try not to blink and do not rub your eye. Repeat these steps if your dose is for more than 1 drop or for your other eye if so directed.Do not rinse the dropper. Replace cap after use.If you are using this medicine in a child's eye(s), do not get any medicine in the child's mouth. Wash your hands and your child's hands after use to remove any medicine from them.This medication may temporarily change digestion in infants. Do not feed an infant for 4 hours after the infant's eye exam.This medication starts to work in minutes, and its effect usually lasts 24 hours or sometimes longer. Tell your doctor if you continue to have blurred vision, sensitivity to light, or dilated pupils several days after your exam.
SIDE EFFECTS: Burning/stinging/redness of the eye, eye irritation, or temporary blurred vision may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: dizziness, fainting, mental/mood changes (such as confusion, hallucinations, restlessness, strange behavior).Get medical help right away if you have any very serious side effects, including: eye pain/swelling, vision changes (such as seeing rainbows around lights at night), slow/shallow breathing, fast/irregular heartbeat, seizures.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using cyclopentolate, tell your doctor or pharmacist if you are allergic to it; or to belladonna alkaloids (such as atropine); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), Down's syndrome, brain damage or spastic paralysis (in children), heart disease.After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you can do it safely.This medication may make your eyes more sensitive to light. Protect your eyes in bright light. Use dark sunglasses when outdoors.Infants or small children may be more sensitive to the side effects of this drug, especially mental/mood changes. If using this medication in an infant, watch the infant closely for 30 minutes after the medication is applied.Older adults may be more sensitive to side effects of this drug, especially increased pressure in the eye.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: eye medications for glaucoma/increased pressure in the eye (such as dorzolamide, pilocarpine), certain antiarrhythmic drugs (such as quinidine), antihistamines (such as diphenhydramine, meclizine), antispasmodics (such as dicyclomine), certain drugs for Parkinson's disease (including anticholinergics such as trihexyphenidyl), MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), tricyclic antidepressants (such as amitriptyline).
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: flushed/dry skin, blurred vision, fast/irregular heartbeat, fever, mental/mood changes (such as hallucinations), loss of coordination.
NOTES: Do not share this medication with others.
MISSED DOSE: Not applicable.
STORAGE: Store between 46-80 degrees F (8-27 degrees C) away from heat and light. Do not freeze. Keep all medications away from children and pets.If you are using the single-use containers, discard any unused medication immediately after use.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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