Dosing & Uses
Dosage Forms & Strengths
taurolidine/citrate/heparin
injection, catheter lock solution
- (1.35%/3.5%/1000 units) per mL
Catheter-related Bloodstream Infections
Pending FDA approval for prevention of catheter-related bloodstream infections (CRBSIs) in patients with end-stage renal disease (ESRD) receiving hemodialysis through a central venous catheter
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Pharmacology
Mechanism of Action
Taurolidine: Amino acid with broad antimicrobial activity against gram-positive and gram-negative bacteria, as well as mycobacteria; also elicits antifungal effects
Citrate: Exerts anticoagulant effect by chelating ionized calcium, which is a cofactor in the clotting cascade
Heparin: In low doses, it inactivates Factor Xa and inhibits conversion of prothrombin to thrombin
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
