Dhea, Herbal (Herb/Suppl)

Brand and Other Names:dehydroepiandrosterone, herbal, prasterone, herbal
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Suggested Dosing

Adrenal Insufficiency

20-50 mg PO qDay

Osteoporosis

50-100 mg PO qDay

Depression

30-90 mg PO qDay

Erectile Dysfunction

50 mg PO qDay

Systemic Lupus Erythematosus

200 mg PO qDay

Up to 600 mg/day has been used

Alzheimer's Disease

50 mg PO BID

Menopausal Hot Flashes

25-50 mg PO qDay

Vaginal Atrophy

See FDA approved prescription product: prasterone, intravaginal

Orphan Designations

Adrenal insufficiency

  • Orphan designation for adrenal insufficiency replacement therapy
  • Sponsor
    • Paladin Labs, Inc; 6111 Royalmount Avenue, Suite 102; Montreal, Quebec H4P 2T4, Canada

Burns

  • Orphan designation for treatment of serious burns requiring hospitalization; accelerates re-epithelialization of donor sites in burn patients undergoing autologous skin grafting
  • Sponsor
    • Pharmadigm, Inc; 2401 Foothill Drive; Salt Lake City, UT 84109-1405
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Suggested Uses

Addison's disease, adrenal insufficiency, cognitive disorders, depression, erectile dysfunction, immunostimulant, slowing/reversing aging, systemic lupus erythematosus, vaginal atrophy (postmenopausal), menopausal hot flashes, osteoporosis, Alzheimer's disease, weight loss

Efficacy

Some pos. results (Am J Psychiatry 1999 Apr;156(4):646-9; Ann Med Interne (Paris) 1996; 147(4):276-80)

Considered possibly ineffective for Alzheimer's disease, muscle strength, sexual arousal disorder

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Interactions

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal pain

            Acne

            Decreased HDL cholesterol

            Fatigue

            Hair loss

            Headache

            Hirsutism

            Hypertension

            Hypo/hyperglycemia

            Hypomania

            Increased risk of hormone-sensitive tumors (very high dose)

            Insomnia

            Irritability

            Liver dysfunction

            Mania

            Menstrual irregularities

            Nasal congestion

            Psychosis

            Sexual inappropriateness

            Voice deepening (high dose)

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            Warnings

            Contraindications

            Breast cancer, endometriosis, hormone sensitive conditions, ovarian cancer, uterine cancer, uterine fibroids

            Cautions

            Bipolar disorder, concurrent CYP 3A4 substrates, depression, diabetes mellitus, history of mood disorder, impaired liver function

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: avoid use

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Increases production of estrogens and testosterone, decreases production of cortisol; possible effect on neurotransmitters

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.