Dosing & Uses
Dosage Forms & Strengths
syrup
- 2mg/5mL
Allergy Symptoms
2 mg PO q4-6hr
Dosage Forms & Strengths
syrup
- 2mg/5mL
Allergy Symptoms
2-6 years: Syrup: 0.5 mg PO q4-6hr
6-11 years: (syrup) 1 mg PO q4-6hr
>12 years: As adults; (syrup) 2 mg PO q4-6hr
Dose at lower end of dosage range (2 mg PO q4-6hr) or administer less frequently
Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)
Avoid use in elderly because of high incidence of anticholinergic effects
Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity
May exacerbate existing lower urinary conditions or benign prostatic hyperplasia
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown/not recommended
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Mechanism of Action
Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract
Pharmacokinetics
Half-Life: 20-30 hr
Onset: 6 hr
Duration: 24 hr
Peak Plasma Time: 3 hr
Protein Bound: 69-72%
Excretion: Urine
Vd: 2.5-3.2 L/kg (adults); 3.8 L/kg (Children)
Metabolism: Hepatic
Metabolites: Unidentified, at least 2
Sedative effects: Low
Antihistamine activity: High
Anticholinergic activity: Moderate
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
