Dosing & Uses
Dosage Forms & Strengths
syrup
- 2mg/5mL
Allergy Symptoms
2 mg PO q4-6hr
Dosage Forms & Strengths
syrup
- 2mg/5mL
Allergy Symptoms
2-6 years: Syrup: 0.5 mg PO q4-6hr
6-11 years: (syrup) 1 mg PO q4-6hr
>12 years: As adults; (syrup) 2 mg PO q4-6hr
Dose at lower end of dosage range (2 mg PO q4-6hr) or administer less frequently
Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)
Avoid use in elderly because of high incidence of anticholinergic effects
Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity
May exacerbate existing lower urinary conditions or benign prostatic hyperplasia
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (8)
- calcium/magnesium/potassium/sodium oxybates
dexchlorpheniramine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- eluxadoline
dexchlorpheniramine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.
- metoclopramide intranasal
dexchlorpheniramine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- olopatadine intranasal
dexchlorpheniramine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- pitolisant
dexchlorpheniramine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.
- ropeginterferon alfa 2b
ropeginterferon alfa 2b and dexchlorpheniramine both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.
- sodium oxybate
dexchlorpheniramine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- tranylcypromine
tranylcypromine increases effects of dexchlorpheniramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
Monitor Closely (211)
- acrivastine
acrivastine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- albuterol
dexchlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
dexchlorpheniramine and alfentanil both increase sedation. Use Caution/Monitor.
- alprazolam
dexchlorpheniramine and alprazolam both increase sedation. Use Caution/Monitor.
- amifampridine
dexchlorpheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- amisulpride
amisulpride and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- amitriptyline
dexchlorpheniramine and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
dexchlorpheniramine and amobarbital both increase sedation. Use Caution/Monitor.
- amoxapine
dexchlorpheniramine and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
dexchlorpheniramine and apomorphine both increase sedation. Use Caution/Monitor.
- arformoterol
dexchlorpheniramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
dexchlorpheniramine and aripiprazole both increase sedation. Use Caution/Monitor.
- armodafinil
dexchlorpheniramine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- asenapine
asenapine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine transdermal and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- avapritinib
avapritinib and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- azelastine
azelastine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- baclofen
dexchlorpheniramine and baclofen both increase sedation. Use Caution/Monitor.
- belladonna and opium
dexchlorpheniramine and belladonna and opium both increase sedation. Use Caution/Monitor.
- benperidol
dexchlorpheniramine and benperidol both increase sedation. Use Caution/Monitor.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- benzphetamine
dexchlorpheniramine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, dexchlorpheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
brexpiprazole and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- brimonidine
brimonidine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- brivaracetam
brivaracetam and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- buprenorphine
dexchlorpheniramine and buprenorphine both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
dexchlorpheniramine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
- buprenorphine subdermal implant
buprenorphine subdermal implant and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- buprenorphine transdermal
buprenorphine transdermal and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
buprenorphine, long-acting injection and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- butabarbital
dexchlorpheniramine and butabarbital both increase sedation. Use Caution/Monitor.
- butalbital
dexchlorpheniramine and butalbital both increase sedation. Use Caution/Monitor.
- butorphanol
dexchlorpheniramine and butorphanol both increase sedation. Use Caution/Monitor.
- caffeine
dexchlorpheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- carisoprodol
dexchlorpheniramine and carisoprodol both increase sedation. Use Caution/Monitor.
- cenobamate
cenobamate, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor.
- chloral hydrate
dexchlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
dexchlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- chlorpromazine
dexchlorpheniramine and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorzoxazone
dexchlorpheniramine and chlorzoxazone both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- clobazam
dexchlorpheniramine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
dexchlorpheniramine and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
dexchlorpheniramine and clonazepam both increase sedation. Use Caution/Monitor.
- clorazepate
dexchlorpheniramine and clorazepate both increase sedation. Use Caution/Monitor.
- clozapine
dexchlorpheniramine and clozapine both increase sedation. Use Caution/Monitor.
- codeine
dexchlorpheniramine and codeine both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
dexchlorpheniramine and cyclobenzaprine both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- dantrolene
dexchlorpheniramine and dantrolene both increase sedation. Use Caution/Monitor.
- daridorexant
dexchlorpheniramine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desflurane
desflurane and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- desipramine
dexchlorpheniramine and desipramine both increase sedation. Use Caution/Monitor.
- deutetrabenazine
dexchlorpheniramine and deutetrabenazine both increase sedation. Use Caution/Monitor.
- dexfenfluramine
dexchlorpheniramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexchlorpheniramine and dexmedetomidine both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
dexchlorpheniramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
dexchlorpheniramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dexchlorpheniramine and dextromoramide both increase sedation. Use Caution/Monitor.
- diamorphine
dexchlorpheniramine and diamorphine both increase sedation. Use Caution/Monitor.
- diazepam
dexchlorpheniramine and diazepam both increase sedation. Use Caution/Monitor.
- diazepam intranasal
diazepam intranasal, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
- diethylpropion
dexchlorpheniramine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difelikefalin
difelikefalin and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- difenoxin hcl
dexchlorpheniramine and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dexchlorpheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.
- diphenhydramine
dexchlorpheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
dexchlorpheniramine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- dipipanone
dexchlorpheniramine and dipipanone both increase sedation. Use Caution/Monitor.
- dobutamine
dexchlorpheniramine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- donepezil transdermal
donepezil transdermal, dexchlorpheniramine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.
- dopamine
dexchlorpheniramine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
dexchlorpheniramine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
dexchlorpheniramine and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
dexchlorpheniramine and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
dexchlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.
- droperidol
dexchlorpheniramine and droperidol both increase sedation. Use Caution/Monitor.
- ephedrine
dexchlorpheniramine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
dexchlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
dexchlorpheniramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- esketamine intranasal
esketamine intranasal, dexchlorpheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- estazolam
dexchlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.
- ethanol
dexchlorpheniramine and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- fenfluramine
dexchlorpheniramine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fentanyl
fentanyl, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl intranasal
fentanyl intranasal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transdermal
fentanyl transdermal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transmucosal
fentanyl transmucosal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- flibanserin
dexchlorpheniramine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
- fluphenazine
dexchlorpheniramine and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
dexchlorpheniramine and flurazepam both increase sedation. Use Caution/Monitor.
- formoterol
dexchlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- gabapentin
gabapentin, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- gabapentin enacarbil
gabapentin enacarbil, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- ganaxolone
dexchlorpheniramine and ganaxolone both increase sedation. Use Caution/Monitor.
- glycopyrronium tosylate topical
glycopyrronium tosylate topical, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.
- gotu kola
gotu kola increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- haloperidol
dexchlorpheniramine and haloperidol both increase sedation. Use Caution/Monitor.
- hawthorn
hawthorn increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- hops
hops increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- hyaluronidase
dexchlorpheniramine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.
- hydromorphone
dexchlorpheniramine and hydromorphone both increase sedation. Use Caution/Monitor.
- hydroxyzine
dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.
- iloperidone
dexchlorpheniramine and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
dexchlorpheniramine and imipramine both increase sedation. Use Caution/Monitor.
- isoproterenol
dexchlorpheniramine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- kava
kava increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- ketamine
ketamine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, dexchlorpheniramine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- levalbuterol
dexchlorpheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
dexchlorpheniramine and levorphanol both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
dexchlorpheniramine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
dexchlorpheniramine and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
dexchlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
dexchlorpheniramine and loprazolam both increase sedation. Use Caution/Monitor.
- lorazepam
dexchlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.
- lormetazepam
dexchlorpheniramine and lormetazepam both increase sedation. Use Caution/Monitor.
- loxapine
dexchlorpheniramine and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
dexchlorpheniramine and loxapine inhaled both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, dexchlorpheniramine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
dexchlorpheniramine and maprotiline both increase sedation. Use Caution/Monitor.
- marijuana
dexchlorpheniramine and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
dexchlorpheniramine and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
dexchlorpheniramine and meperidine both increase sedation. Use Caution/Monitor.
- meprobamate
dexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
dexchlorpheniramine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
dexchlorpheniramine and metaxalone both increase sedation. Use Caution/Monitor.
- methadone
dexchlorpheniramine and methadone both increase sedation. Use Caution/Monitor.
- methamphetamine
dexchlorpheniramine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
dexchlorpheniramine and methocarbamol both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
dexchlorpheniramine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
dexchlorpheniramine and midazolam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
dexchlorpheniramine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
dexchlorpheniramine and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
dexchlorpheniramine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
dexchlorpheniramine and morphine both increase sedation. Use Caution/Monitor.
- motherwort
dexchlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
dexchlorpheniramine and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
dexchlorpheniramine and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
dexchlorpheniramine and nalbuphine both increase sedation. Use Caution/Monitor.
- norepinephrine
dexchlorpheniramine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
dexchlorpheniramine and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
dexchlorpheniramine and olanzapine both increase sedation. Use Caution/Monitor.
- opium tincture
dexchlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
dexchlorpheniramine and orphenadrine both increase sedation. Use Caution/Monitor.
- oxazepam
dexchlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.
- oxycodone
dexchlorpheniramine and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
dexchlorpheniramine and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
dexchlorpheniramine and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
dexchlorpheniramine and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
dexchlorpheniramine and papaverine both increase sedation. Use Caution/Monitor.
- passion flower
passion flower increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- pentazocine
dexchlorpheniramine and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
dexchlorpheniramine and pentobarbital both increase sedation. Use Caution/Monitor.
- perphenazine
dexchlorpheniramine and perphenazine both increase sedation. Use Caution/Monitor.
- phendimetrazine
dexchlorpheniramine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenelzine
phenelzine increases effects of dexchlorpheniramine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
- phenobarbital
dexchlorpheniramine and phenobarbital both increase sedation. Use Caution/Monitor.
- phentermine
dexchlorpheniramine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
dexchlorpheniramine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
dexchlorpheniramine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
dexchlorpheniramine and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
dexchlorpheniramine and pimozide both increase sedation. Use Caution/Monitor.
- pirbuterol
dexchlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pregabalin
pregabalin, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- primidone
dexchlorpheniramine and primidone both increase sedation. Use Caution/Monitor.
- prochlorperazine
dexchlorpheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
dexchlorpheniramine and promethazine both increase sedation. Use Caution/Monitor.
- propofol
propofol and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- propylhexedrine
dexchlorpheniramine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
dexchlorpheniramine and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
dexchlorpheniramine and quazepam both increase sedation. Use Caution/Monitor.
- quetiapine
dexchlorpheniramine and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
dexchlorpheniramine and ramelteon both increase sedation. Use Caution/Monitor.
- risperidone
dexchlorpheniramine and risperidone both increase sedation. Use Caution/Monitor.
- salmeterol
dexchlorpheniramine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
dexchlorpheniramine and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
dexchlorpheniramine and secobarbital both increase sedation. Use Caution/Monitor.
- sevoflurane
sevoflurane and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- shepherd's purse
dexchlorpheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
dexchlorpheniramine and sufentanil both increase sedation. Use Caution/Monitor.
- tapentadol
dexchlorpheniramine and tapentadol both increase sedation. Use Caution/Monitor.
- temazepam
dexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.
- terbutaline
dexchlorpheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
dexchlorpheniramine and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
dexchlorpheniramine and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
dexchlorpheniramine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
dexchlorpheniramine and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
dexchlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
dexchlorpheniramine and triazolam both increase sedation. Use Caution/Monitor.
- triclofos
dexchlorpheniramine and triclofos both increase sedation. Use Caution/Monitor.
- trifluoperazine
dexchlorpheniramine and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
dexchlorpheniramine and trimipramine both increase sedation. Use Caution/Monitor.
- triprolidine
dexchlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.
- valerian
valerian increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- xylometazoline
dexchlorpheniramine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
dexchlorpheniramine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
dexchlorpheniramine and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
dexchlorpheniramine and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
dexchlorpheniramine and zotepine both increase sedation. Use Caution/Monitor.
Minor (6)
- ashwagandha
ashwagandha increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- brimonidine
brimonidine increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- eucalyptus
dexchlorpheniramine and eucalyptus both increase sedation. Minor/Significance Unknown.
- nettle
nettle increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
- sage
dexchlorpheniramine and sage both increase sedation. Minor/Significance Unknown.
- Siberian ginseng
Siberian ginseng increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown/not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract
Pharmacokinetics
Half-Life: 20-30 hr
Onset: 6 hr
Duration: 24 hr
Peak Plasma Time: 3 hr
Protein Bound: 69-72%
Excretion: Urine
Vd: 2.5-3.2 L/kg (adults); 3.8 L/kg (Children)
Metabolism: Hepatic
Metabolites: Unidentified, at least 2
Sedative effects: Low
Antihistamine activity: High
Anticholinergic activity: Moderate
Images
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.