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    For You News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
    Drugs & Diseases

    dexchlorpheniramine (Rx)

    Brand and Other Names:
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    Dosing & Uses

    AdultPediatricGeriatric

    Dosage Forms & Strengths

    syrup

    • 2mg/5mL

    Allergy Symptoms

    2 mg PO q4-6hr

    Dosage Forms & Strengths

    syrup

    • 2mg/5mL

    Allergy Symptoms

    2-6 years: Syrup: 0.5 mg PO q4-6hr

    6-11 years: (syrup) 1 mg PO q4-6hr

    >12 years: As adults; (syrup) 2 mg PO q4-6hr

    Dose at lower end of dosage range (2 mg PO q4-6hr) or administer less frequently

    Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)

    Avoid use in elderly because of high incidence of anticholinergic effects

    Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity

    May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

    Next:

    Interactions

    Interaction Checker

    and dexchlorpheniramine

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                Serious - Use Alternative (6)

                • calcium/magnesium/potassium/sodium oxybates

                  dexchlorpheniramine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                • eluxadoline

                  dexchlorpheniramine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.

                • metoclopramide intranasal

                  dexchlorpheniramine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

                • pitolisant

                  dexchlorpheniramine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.

                • sodium oxybate

                  dexchlorpheniramine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                • tranylcypromine

                  tranylcypromine increases effects of dexchlorpheniramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

                Monitor Closely (195)

                • albuterol

                  dexchlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • alfentanil

                  dexchlorpheniramine and alfentanil both increase sedation. Use Caution/Monitor.

                • alprazolam

                  dexchlorpheniramine and alprazolam both increase sedation. Use Caution/Monitor.

                • amifampridine

                  dexchlorpheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.

                • amitriptyline

                  dexchlorpheniramine and amitriptyline both increase sedation. Use Caution/Monitor.

                • amobarbital

                  dexchlorpheniramine and amobarbital both increase sedation. Use Caution/Monitor.

                • amoxapine

                  dexchlorpheniramine and amoxapine both increase sedation. Use Caution/Monitor.

                • apomorphine

                  dexchlorpheniramine and apomorphine both increase sedation. Use Caution/Monitor.

                • arformoterol

                  dexchlorpheniramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • aripiprazole

                  dexchlorpheniramine and aripiprazole both increase sedation. Use Caution/Monitor.

                • armodafinil

                  dexchlorpheniramine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • azelastine

                  azelastine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • baclofen

                  dexchlorpheniramine and baclofen both increase sedation. Use Caution/Monitor.

                • belladonna and opium

                  dexchlorpheniramine and belladonna and opium both increase sedation. Use Caution/Monitor.

                • benperidol

                  dexchlorpheniramine and benperidol both increase sedation. Use Caution/Monitor.

                • benzphetamine

                  dexchlorpheniramine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • brexanolone

                  brexanolone, dexchlorpheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.

                • brompheniramine

                  brompheniramine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • buprenorphine

                  dexchlorpheniramine and buprenorphine both increase sedation. Use Caution/Monitor.

                • buprenorphine buccal

                  dexchlorpheniramine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

                • butabarbital

                  dexchlorpheniramine and butabarbital both increase sedation. Use Caution/Monitor.

                • butalbital

                  dexchlorpheniramine and butalbital both increase sedation. Use Caution/Monitor.

                • butorphanol

                  dexchlorpheniramine and butorphanol both increase sedation. Use Caution/Monitor.

                • caffeine

                  dexchlorpheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • carbinoxamine

                  carbinoxamine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • carisoprodol

                  dexchlorpheniramine and carisoprodol both increase sedation. Use Caution/Monitor.

                • cenobamate

                  cenobamate, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor.

                • chloral hydrate

                  dexchlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.

                • chlordiazepoxide

                  dexchlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

                • chlorpheniramine

                  chlorpheniramine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • chlorpromazine

                  dexchlorpheniramine and chlorpromazine both increase sedation. Use Caution/Monitor.

                • chlorzoxazone

                  dexchlorpheniramine and chlorzoxazone both increase sedation. Use Caution/Monitor.

                • cinnarizine

                  cinnarizine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • clemastine

                  clemastine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • clobazam

                  dexchlorpheniramine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

                • clomipramine

                  dexchlorpheniramine and clomipramine both increase sedation. Use Caution/Monitor.

                • clonazepam

                  dexchlorpheniramine and clonazepam both increase sedation. Use Caution/Monitor.

                • clorazepate

                  dexchlorpheniramine and clorazepate both increase sedation. Use Caution/Monitor.

                • clozapine

                  dexchlorpheniramine and clozapine both increase sedation. Use Caution/Monitor.

                • codeine

                  dexchlorpheniramine and codeine both increase sedation. Use Caution/Monitor.

                • cyclizine

                  cyclizine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • cyclobenzaprine

                  dexchlorpheniramine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

                • cyproheptadine

                  cyproheptadine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • dantrolene

                  dexchlorpheniramine and dantrolene both increase sedation. Use Caution/Monitor.

                • desflurane

                  desflurane and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • desipramine

                  dexchlorpheniramine and desipramine both increase sedation. Use Caution/Monitor.

                • deutetrabenazine

                  dexchlorpheniramine and deutetrabenazine both increase sedation. Use Caution/Monitor.

                • dexfenfluramine

                  dexchlorpheniramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dexmedetomidine

                  dexchlorpheniramine and dexmedetomidine both increase sedation. Use Caution/Monitor.

                • dexmethylphenidate

                  dexchlorpheniramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextroamphetamine

                  dexchlorpheniramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextromoramide

                  dexchlorpheniramine and dextromoramide both increase sedation. Use Caution/Monitor.

                • diamorphine

                  dexchlorpheniramine and diamorphine both increase sedation. Use Caution/Monitor.

                • diazepam

                  dexchlorpheniramine and diazepam both increase sedation. Use Caution/Monitor.

                • diazepam intranasal

                  diazepam intranasal, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

                • diethylpropion

                  dexchlorpheniramine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • difenoxin hcl

                  dexchlorpheniramine and difenoxin hcl both increase sedation. Use Caution/Monitor.

                • dimenhydrinate

                  dexchlorpheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.

                • diphenhydramine

                  dexchlorpheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.

                • diphenoxylate hcl

                  dexchlorpheniramine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

                • dipipanone

                  dexchlorpheniramine and dipipanone both increase sedation. Use Caution/Monitor.

                • dobutamine

                  dexchlorpheniramine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopamine

                  dexchlorpheniramine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopexamine

                  dexchlorpheniramine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dosulepin

                  dexchlorpheniramine and dosulepin both increase sedation. Use Caution/Monitor.

                • doxepin

                  dexchlorpheniramine and doxepin both increase sedation. Use Caution/Monitor.

                • doxylamine

                  dexchlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.

                • droperidol

                  dexchlorpheniramine and droperidol both increase sedation. Use Caution/Monitor.

                • ephedrine

                  dexchlorpheniramine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine

                  dexchlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine racemic

                  dexchlorpheniramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • esketamine intranasal

                  esketamine intranasal, dexchlorpheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

                • estazolam

                  dexchlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.

                • ethanol

                  dexchlorpheniramine and ethanol both increase sedation. Use Caution/Monitor.

                • etomidate

                  etomidate and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • fenfluramine

                  dexchlorpheniramine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fentanyl

                  fentanyl, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                • fentanyl intranasal

                  fentanyl intranasal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                • fentanyl transdermal

                  fentanyl transdermal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                • fentanyl transmucosal

                  fentanyl transmucosal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

                • flibanserin

                  dexchlorpheniramine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

                • fluphenazine

                  dexchlorpheniramine and fluphenazine both increase sedation. Use Caution/Monitor.

                • flurazepam

                  dexchlorpheniramine and flurazepam both increase sedation. Use Caution/Monitor.

                • formoterol

                  dexchlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • gabapentin

                  gabapentin, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                • gabapentin enacarbil

                  gabapentin enacarbil, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                • glycopyrronium tosylate topical

                  glycopyrronium tosylate topical, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

                • gotu kola

                  gotu kola increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • haloperidol

                  dexchlorpheniramine and haloperidol both increase sedation. Use Caution/Monitor.

                • hawthorn

                  hawthorn increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • hops

                  hops increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • hyaluronidase

                  dexchlorpheniramine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

                • hydromorphone

                  dexchlorpheniramine and hydromorphone both increase sedation. Use Caution/Monitor.

                • hydroxyzine

                  dexchlorpheniramine and hydroxyzine both increase sedation. Use Caution/Monitor.

                • iloperidone

                  dexchlorpheniramine and iloperidone both increase sedation. Use Caution/Monitor.

                • imipramine

                  dexchlorpheniramine and imipramine both increase sedation. Use Caution/Monitor.

                • isoproterenol

                  dexchlorpheniramine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • kava

                  kava increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • ketamine

                  ketamine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • ketotifen, ophthalmic

                  dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lasmiditan

                  lasmiditan, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

                • lemborexant

                  lemborexant, dexchlorpheniramine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

                • levalbuterol

                  dexchlorpheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • levorphanol

                  dexchlorpheniramine and levorphanol both increase sedation. Use Caution/Monitor.

                • lisdexamfetamine

                  dexchlorpheniramine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • lofepramine

                  dexchlorpheniramine and lofepramine both increase sedation. Use Caution/Monitor.

                • lofexidine

                  dexchlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.

                • loprazolam

                  dexchlorpheniramine and loprazolam both increase sedation. Use Caution/Monitor.

                • lorazepam

                  dexchlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.

                • lormetazepam

                  dexchlorpheniramine and lormetazepam both increase sedation. Use Caution/Monitor.

                • loxapine

                  dexchlorpheniramine and loxapine both increase sedation. Use Caution/Monitor.

                • loxapine inhaled

                  dexchlorpheniramine and loxapine inhaled both increase sedation. Use Caution/Monitor.

                • lurasidone

                  lurasidone, dexchlorpheniramine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                • maprotiline

                  dexchlorpheniramine and maprotiline both increase sedation. Use Caution/Monitor.

                • marijuana

                  dexchlorpheniramine and marijuana both increase sedation. Use Caution/Monitor.

                • melatonin

                  dexchlorpheniramine and melatonin both increase sedation. Use Caution/Monitor.

                • meperidine

                  dexchlorpheniramine and meperidine both increase sedation. Use Caution/Monitor.

                • meprobamate

                  dexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.

                • metaproterenol

                  dexchlorpheniramine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • metaxalone

                  dexchlorpheniramine and metaxalone both increase sedation. Use Caution/Monitor.

                • methadone

                  dexchlorpheniramine and methadone both increase sedation. Use Caution/Monitor.

                • methamphetamine

                  dexchlorpheniramine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • methocarbamol

                  dexchlorpheniramine and methocarbamol both increase sedation. Use Caution/Monitor.

                • methylenedioxymethamphetamine

                  dexchlorpheniramine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • midazolam

                  dexchlorpheniramine and midazolam both increase sedation. Use Caution/Monitor.

                • midazolam intranasal

                  midazolam intranasal, dexchlorpheniramine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

                • midodrine

                  dexchlorpheniramine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • mirtazapine

                  dexchlorpheniramine and mirtazapine both increase sedation. Use Caution/Monitor.

                • modafinil

                  dexchlorpheniramine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • morphine

                  dexchlorpheniramine and morphine both increase sedation. Use Caution/Monitor.

                • motherwort

                  dexchlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.

                • moxonidine

                  dexchlorpheniramine and moxonidine both increase sedation. Use Caution/Monitor.

                • nabilone

                  dexchlorpheniramine and nabilone both increase sedation. Use Caution/Monitor.

                • nalbuphine

                  dexchlorpheniramine and nalbuphine both increase sedation. Use Caution/Monitor.

                • norepinephrine

                  dexchlorpheniramine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nortriptyline

                  dexchlorpheniramine and nortriptyline both increase sedation. Use Caution/Monitor.

                • olanzapine

                  dexchlorpheniramine and olanzapine both increase sedation. Use Caution/Monitor.

                • opium tincture

                  dexchlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.

                • orphenadrine

                  dexchlorpheniramine and orphenadrine both increase sedation. Use Caution/Monitor.

                • oxazepam

                  dexchlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.

                • oxycodone

                  dexchlorpheniramine and oxycodone both increase sedation. Use Caution/Monitor.

                • oxymorphone

                  dexchlorpheniramine and oxymorphone both increase sedation. Use Caution/Monitor.

                • paliperidone

                  dexchlorpheniramine and paliperidone both increase sedation. Use Caution/Monitor.

                • papaveretum

                  dexchlorpheniramine and papaveretum both increase sedation. Use Caution/Monitor.

                • papaverine

                  dexchlorpheniramine and papaverine both increase sedation. Use Caution/Monitor.

                • passion flower

                  passion flower increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • pentazocine

                  dexchlorpheniramine and pentazocine both increase sedation. Use Caution/Monitor.

                • pentobarbital

                  dexchlorpheniramine and pentobarbital both increase sedation. Use Caution/Monitor.

                • perphenazine

                  dexchlorpheniramine and perphenazine both increase sedation. Use Caution/Monitor.

                • phendimetrazine

                  dexchlorpheniramine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenelzine

                  phenelzine increases effects of dexchlorpheniramine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .

                • phenobarbital

                  dexchlorpheniramine and phenobarbital both increase sedation. Use Caution/Monitor.

                • phentermine

                  dexchlorpheniramine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine

                  dexchlorpheniramine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine PO

                  dexchlorpheniramine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • pholcodine

                  dexchlorpheniramine and pholcodine both increase sedation. Use Caution/Monitor.

                • pimozide

                  dexchlorpheniramine and pimozide both increase sedation. Use Caution/Monitor.

                • pirbuterol

                  dexchlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • pregabalin

                  pregabalin, dexchlorpheniramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

                • primidone

                  dexchlorpheniramine and primidone both increase sedation. Use Caution/Monitor.

                • prochlorperazine

                  dexchlorpheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.

                • promethazine

                  dexchlorpheniramine and promethazine both increase sedation. Use Caution/Monitor.

                • propofol

                  propofol and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • propylhexedrine

                  dexchlorpheniramine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • protriptyline

                  dexchlorpheniramine and protriptyline both increase sedation. Use Caution/Monitor.

                • quazepam

                  dexchlorpheniramine and quazepam both increase sedation. Use Caution/Monitor.

                • quetiapine

                  dexchlorpheniramine and quetiapine both increase sedation. Use Caution/Monitor.

                • ramelteon

                  dexchlorpheniramine and ramelteon both increase sedation. Use Caution/Monitor.

                • risperidone

                  dexchlorpheniramine and risperidone both increase sedation. Use Caution/Monitor.

                • salmeterol

                  dexchlorpheniramine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • scullcap

                  dexchlorpheniramine and scullcap both increase sedation. Use Caution/Monitor.

                • secobarbital

                  dexchlorpheniramine and secobarbital both increase sedation. Use Caution/Monitor.

                • sevoflurane

                  sevoflurane and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • shepherd's purse

                  dexchlorpheniramine and shepherd's purse both increase sedation. Use Caution/Monitor.

                • stiripentol

                  stiripentol, dexchlorpheniramine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

                • sufentanil

                  dexchlorpheniramine and sufentanil both increase sedation. Use Caution/Monitor.

                • tapentadol

                  dexchlorpheniramine and tapentadol both increase sedation. Use Caution/Monitor.

                • temazepam

                  dexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.

                • terbutaline

                  dexchlorpheniramine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • thioridazine

                  dexchlorpheniramine and thioridazine both increase sedation. Use Caution/Monitor.

                • thiothixene

                  dexchlorpheniramine and thiothixene both increase sedation. Use Caution/Monitor.

                • topiramate

                  dexchlorpheniramine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                • tramadol

                  dexchlorpheniramine and tramadol both increase sedation. Use Caution/Monitor.

                • trazodone

                  dexchlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.

                • triazolam

                  dexchlorpheniramine and triazolam both increase sedation. Use Caution/Monitor.

                • triclofos

                  dexchlorpheniramine and triclofos both increase sedation. Use Caution/Monitor.

                • trifluoperazine

                  dexchlorpheniramine and trifluoperazine both increase sedation. Use Caution/Monitor.

                • trimipramine

                  dexchlorpheniramine and trimipramine both increase sedation. Use Caution/Monitor.

                • triprolidine

                  dexchlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.

                • valerian

                  valerian increases effects of dexchlorpheniramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                • xylometazoline

                  dexchlorpheniramine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • yohimbine

                  dexchlorpheniramine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ziconotide

                  dexchlorpheniramine and ziconotide both increase sedation. Use Caution/Monitor.

                • ziprasidone

                  dexchlorpheniramine and ziprasidone both increase sedation. Use Caution/Monitor.

                • zotepine

                  dexchlorpheniramine and zotepine both increase sedation. Use Caution/Monitor.

                Minor (6)

                • ashwagandha

                  ashwagandha increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                • brimonidine

                  brimonidine increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • eucalyptus

                  dexchlorpheniramine and eucalyptus both increase sedation. Minor/Significance Unknown.

                • nettle

                  nettle increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • sage

                  dexchlorpheniramine and sage both increase sedation. Minor/Significance Unknown.

                • Siberian ginseng

                  Siberian ginseng increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

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                Pregnancy & Lactation

                Pregnancy Category: B

                Lactation: excretion in milk unknown/not recommended

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract

                Pharmacokinetics

                Half-Life: 20-30 hr

                Onset: 6 hr

                Duration: 24 hr

                Peak Plasma Time: 3 hr

                Protein Bound: 69-72%

                Excretion: Urine

                Vd: 2.5-3.2 L/kg (adults); 3.8 L/kg (Children)

                Metabolism: Hepatic

                Metabolites: Unidentified, at least 2

                Sedative effects: Low

                Antihistamine activity: High

                Anticholinergic activity: Moderate

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                Images

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                Patient Handout

                A Patient Handout is not currently available for this monograph.
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                Formulary

                FormularyPatient Discounts

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                Create Your List of Plans

                Adding plans allows you to:

                • View the formulary and any restrictions for each plan.
                • Manage and view all your plans together – even plans in different states.
                • Compare formulary status to other drugs in the same class.
                • Access your plan list on any device – mobile or desktop.

                The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                View explanations for tiers and restrictions
                Tier Description
                1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                NC NOT COVERED – Drugs that are not covered by the plan.
                Code Definition
                PA Prior Authorization
                Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                QL Quantity Limits
                Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                ST Step Therapy
                Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                OR Other Restrictions
                Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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