(dicloxacillin) dosing, indications, interactions, adverse effects, and more

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Sections dicloxacillin
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

250mg
500mg

Infections

Indicated for Staphylococcus aureus infections

125-500 mg PO q6hr

Take on empty stomach

Renal Impairment

Not studied; total dosage reduction should be considered

Hepatic Impairment

Not studied

Dosage Forms & Strengths

capsule

250mg
500mg

Infections

Indicated for Staphylococcus aureus infections

<40 kg: 12.5-25 mg/kg/day PO divided q6hr

Severe infection: 50-100 mg/kg/day PO divided q6hr

≥40 kg: 125-500 mg PO q6hr

Take on empty stomach

Interaction Checker

Enter a drug name and dicloxacillin

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Contraindicated

Serious - Use Alternative

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1-10%

Abdominal pain

Diarrhea

Nausea

<1%

Anemia

Elevated LFTs

Fever

Hypersensitivity

Nephritis

Pseudomembranous colitis

Seizures with extremely high doses &/or renal failure

Rash (maculopapular to exfoliative)

Vomiting

Vaginitis

Contraindications

Hypersensitivity to penicillins, cephalosporins, imipenem

Initial treatment of severe infections

Concomitant live bacterial vaccines

Cautions

Monitor PT if patient is taking warfarin concurrently

Prolonged use may result in superinfection

Elimination of drug in neonates is slow; use caution

Pregnancy & Lactation

Pregnancy Category: B

Lactation: excreted in breast milk, use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Binds to one or more penicillin binding proteins, which in turn inhibit synthesis of bacterial cell wall synthesis. For treatment of infections caused by penicillinase-producing staphylococci.

Resistance to this drug results from alterations in penicillin-binding proteins.

Pharmacokinetics

Half-Life: 0.6-0.8 hr

Peak Plasma Time: 0.5-2 hr

Protein Bound: 96%

Absorption: 35-76%, decreased by food

Distribution: widespread, highest in kidneys & liver, CSF low

Metabolism: hepatic CYP3A4

Excretion: Urine (56%), feces

Images

Patient Handout

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections dicloxacillin
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

dicloxacillin (Rx)

Dosing & Uses

Dosage Forms & Strengths

capsule

Infections

Renal Impairment

Hepatic Impairment

Dosage Forms & Strengths

capsule

Infections

Interactions

Interaction Checker

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

Adverse Effects

1-10%

<1%

Warnings

Contraindications

Cautions

Pregnancy & Lactation

Pregnancy Categories

Pharmacology

Mechanism of Action

Pharmacokinetics

Images

Patient Handout

Formulary

Plans

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