Dosing & Uses
Dosage Forms & Strengths
capsule
- 250mg
- 500mg
Infections
Indicated for Staphylococcus aureus infections
125-500 mg PO q6hr
Take on empty stomach
Renal Impairment
Not studied; total dosage reduction should be considered
Hepatic Impairment
Not studied
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
1-10%
Abdominal pain
Diarrhea
Nausea
<1%
Anemia
Elevated LFTs
Fever
Hypersensitivity
Nephritis
Pseudomembranous colitis
Seizures with extremely high doses &/or renal failure
Rash (maculopapular to exfoliative)
Vomiting
Vaginitis
Warnings
Contraindications
Hypersensitivity to penicillins, cephalosporins, imipenem
Initial treatment of severe infections
Concomitant live bacterial vaccines
Cautions
Monitor PT if patient is taking warfarin concurrently
Prolonged use may result in superinfection
Elimination of drug in neonates is slow; use caution
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excreted in breast milk, use caution
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Mechanism of Action
Binds to one or more penicillin binding proteins, which in turn inhibit synthesis of bacterial cell wall synthesis. For treatment of infections caused by penicillinase-producing staphylococci.
Resistance to this drug results from alterations in penicillin-binding proteins.
Pharmacokinetics
Half-Life: 0.6-0.8 hr
Peak Plasma Time: 0.5-2 hr
Protein Bound: 96%
Absorption: 35-76%, decreased by food
Distribution: widespread, highest in kidneys & liver, CSF low
Metabolism: hepatic CYP3A4
Excretion: Urine (56%), feces
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
