Piracetam (Herb/Suppl)

Brand and Other Names:dinagen, myocalm, more...nootropil, qropi
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Suggested Dosing

AdultPediatric

1.6-9.6 g/day PO

<16 years old: not recommended

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Suggested Uses

Alzheimers disease, dementia, memory dysfunction, alcoholism, Raynaud's phenomenon, DVT, stroke, tardive dyskinesia, dyslexia, brain injury, vertigo

Efficacy

Approved in many European countries for myoclonus, aging-related conditions (dementia, Alzheimer's)

Some clinical studies show efficacy in dyslexia, brain injury, vertigo

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Interactions

Interaction Checker

and Piracetam

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (7)

                • cilostazol

                  piracetam increases effects of cilostazol by pharmacodynamic synergism. Use Caution/Monitor.

                • clopidogrel

                  piracetam increases effects of clopidogrel by pharmacodynamic synergism. Use Caution/Monitor.

                • dipyridamole

                  piracetam increases effects of dipyridamole by pharmacodynamic synergism. Use Caution/Monitor.

                • eptifibatide

                  piracetam increases effects of eptifibatide by pharmacodynamic synergism. Use Caution/Monitor.

                • prasugrel

                  piracetam increases effects of prasugrel by pharmacodynamic synergism. Use Caution/Monitor.

                • ticlopidine

                  piracetam increases effects of ticlopidine by pharmacodynamic synergism. Use Caution/Monitor.

                • tirofiban

                  piracetam increases effects of tirofiban by pharmacodynamic synergism. Use Caution/Monitor.

                Minor (3)

                • levothyroxine

                  piracetam, levothyroxine. Mechanism: unknown. Minor/Significance Unknown. Combination of piracetam and T3+T4 produced confusion, sleep disorder in single case.

                • liothyronine

                  piracetam, liothyronine. Mechanism: unknown. Minor/Significance Unknown. Combination of piracetam and T3+T4 produced confusion, sleep disorder in single case.

                • thyroid desiccated

                  piracetam, thyroid desiccated. Mechanism: unknown. Minor/Significance Unknown. Combination of piracetam and T3+T4 produced confusion, sleep disorder in single case.

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                Adverse Effects

                Frequency not defined

                diarrhea, weight gain, somnolence, insomnia, nervousness, depression, hyperkinesia, rash

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                Warnings

                Contraindications

                Hepatic impairment

                Severe renal impairment

                Pregnancy, lactation

                Hemorrhagic diathesis

                Cautions

                Avoid abrupt withdrawal

                Elderly

                Renal impairment

                May impair ability to drive or perform hazardous tasks

                Blood dyscrasias

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                Pregnancy & Lactation

                Pregnancy Category: contraindicated

                Lactation: contraindicated

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Peak Plasma Time: 1.5 hr

                Half-Life: 5 hr

                Bioavailability: ~100%

                Metabolism: no identified metabolites

                Excretion: urine

                Mechanism of Action

                Unknown, GABA analog

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.