Dosing & Uses
Dosage Forms & Strengths
topical solution
- 0.005%
topical ointment
- 0.005%
topical cream
- 0.005%
topical foam
- 0.005%
Moderate Plaque Psoriasis
Ointment/Cream
- Apply thin layer to affected skin BID
Solution
- Apply to affected scalp BID
Foam
- Apply thin layer topically to affected skin BID
Administration
Rub in gently and completely
May use for up to 8 weeks
Other Information
Foam is flammable, contents under pressure, do not expose to heat or store at temperatures above 120 degrees F
Safety and efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
>10%
Burning
Itching
Skin irritation
1-10%
Dermatitis
Dry skin
Erythema
Peeling
Worsening of psoriasis including facial/scalp
Rash
<1%
Folliculitis
Hypercalcemia
Hyperpigmentation
Skin atrophy
Postmarketing Reports
Contact dermatitis, including allergic contact dermatitis
Warnings
Contraindications
Hypersensitivity, use on face, hypercalcemia, or evidence Vit D toxicity
Cautions
Photosensitivity reported; avoid excessive exposure to natural or artificial sunlight
Contact dermatitis, including allergic contact dermatitis, reported
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Absorption: 5-6% systemically
Metabolism: converted to inactive metabolites within 24 hr
Excretion: bile
Mechanism of Action
In vitro evidence suggests drug is roughly equipotent to natural vitamin D in its effects on proliferation & differentiation of various cell types
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
