Squill (Herb/Suppl)

Brand and Other Names:drimia maritima, Indian squill, more...scilia, sea onion, sea squill, urginea maritima, white squill
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Suggested Dosing

0.1-0.5 g/d PO

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Suggested Uses

Arrhythmia, vein problems, weak heart

Efficacy: contains cardiac glycosides similar to digoxin

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Interactions

Interaction Checker

and Squill

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (1)

            • digoxin

              squill, digoxin. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.

            Serious - Use Alternative (23)

            • bendroflumethiazide

              bendroflumethiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • budesonide

              budesonide increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • bumetanide

              bumetanide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • chlorothiazide

              chlorothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • chlorthalidone

              chlorthalidone increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • cortisone

              cortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • cyclopenthiazide

              cyclopenthiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • deflazacort

              deflazacort increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • dexamethasone

              dexamethasone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • ethacrynic acid

              ethacrynic acid increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • fludrocortisone

              fludrocortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • furosemide

              furosemide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • hydrochlorothiazide

              hydrochlorothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • hydrocortisone

              hydrocortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • indapamide

              indapamide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • methyclothiazide

              methyclothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • methylprednisolone

              methylprednisolone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • metolazone

              metolazone increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • prednisolone

              prednisolone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • prednisone

              prednisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            • quinidine

              quinidine increases toxicity of squill by pharmacodynamic synergism. Avoid or Use Alternate Drug.

            • torsemide

              torsemide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.

            • triamcinolone acetonide injectable suspension

              triamcinolone acetonide injectable suspension increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.

            Monitor Closely (5)

            • calcium acetate

              calcium acetate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.

            • calcium carbonate

              calcium carbonate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.

            • calcium chloride

              calcium chloride increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.

            • calcium citrate

              calcium citrate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.

            • calcium gluconate

              calcium gluconate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.

            Minor (0)

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              Adverse Effects

              Frequency Not Defined

              Digestive spasms

              Loss of appetite

              Vomiting

              Diarrhea

              Headache

              Irregular pulse

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              Warnings

              Contraindications

              None reported

              Cautions

              Safer alternatives now available

              Avoid excess intake

              Contact fresh bulb juice may cause skin inflammations

              Red squill is poisonous (see digoxin OD)

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              Pregnancy & Lactation

              Pregnancy Category: N/A

              Lactation: N/A

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Metabolism: N/A

              Excretion: N/A

              Mechanism of Action

              Boosts cardiac output & slows HR

              Lowers excessive blood pressure in veins

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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.