Suggested Dosing
0.1-0.5 g/d PO
Suggested Uses
Arrhythmia, vein problems, weak heart
Efficacy: contains cardiac glycosides similar to digoxin
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (1)
- digoxin
squill, digoxin. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
Serious - Use Alternative (23)
- bendroflumethiazide
bendroflumethiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- budesonide
budesonide increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- bumetanide
bumetanide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- chlorothiazide
chlorothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- chlorthalidone
chlorthalidone increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- cortisone
cortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- cyclopenthiazide
cyclopenthiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- deflazacort
deflazacort increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- dexamethasone
dexamethasone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- ethacrynic acid
ethacrynic acid increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- fludrocortisone
fludrocortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- furosemide
furosemide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- hydrochlorothiazide
hydrochlorothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- hydrocortisone
hydrocortisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- indapamide
indapamide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- methyclothiazide
methyclothiazide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- methylprednisolone
methylprednisolone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- metolazone
metolazone increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- prednisolone
prednisolone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- prednisone
prednisone increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
- quinidine
quinidine increases toxicity of squill by pharmacodynamic synergism. Avoid or Use Alternate Drug.
- torsemide
torsemide increases toxicity of squill by Other (see comment). Avoid or Use Alternate Drug. Comment: Potassium depletion may enhance toxicity of squill.
- triamcinolone acetonide injectable suspension
triamcinolone acetonide injectable suspension increases toxicity of squill by unspecified interaction mechanism. Avoid or Use Alternate Drug.
Monitor Closely (5)
- calcium acetate
calcium acetate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.
- calcium carbonate
calcium carbonate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.
- calcium chloride
calcium chloride increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.
- calcium citrate
calcium citrate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.
- calcium gluconate
calcium gluconate increases toxicity of squill by unspecified interaction mechanism. Use Caution/Monitor.
Minor (0)
Adverse Effects
Frequency Not Defined
Digestive spasms
Loss of appetite
Vomiting
Diarrhea
Headache
Irregular pulse
Warnings
Contraindications
None reported
Cautions
Safer alternatives now available
Avoid excess intake
Contact fresh bulb juice may cause skin inflammations
Red squill is poisonous (see digoxin OD)
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Boosts cardiac output & slows HR
Lowers excessive blood pressure in veins
