Dosing & Uses
Dosage Forms & Strengths
cream
- 0.5%
- 1%
- 1.2%
Psoriasis
1% cream: Rub cream qDay well into psoriatic lesions in skin until absorbed; avoid applying excessive quantity
0.5% scalp cream: Apply as directed after washing hair and remove by washing or showering
Safety & efficacy not established
Adverse Effects
Frequency Not Defined
Allergic reactions around surrounding uninvolved skin
Temporary discoloration of skin
Lesion soreness
Staining of hair, skin, and fingernails
Warnings
Contraindications
Hypersensitivity
Acute or actively inflamed psoriatic eruptions
Cautions
Avoid contact with eyes or mucous membranes
If redness observed reduce frequency of application or discontinue therapy
May stain fingernails, hair, or fabrics
Use with caution in patients with extensive and prolonged applications
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown/not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Not fully understood
Inhibits cell proliferation putatively through inhibition of DNA synthesis as well as from its strong reducing properties
Anti-psoriatic action may be partly through inactivating epidermal 12-lipoxygenase & reducing levels of endothelial cell adhesion molecules which are markedly elevated in psoriasis
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
