bisacodyl (OTC)

Brand and Other Names:Dulcolax, Correctol, more...BisacEvac, Bisacolax, Codulax, Alophen, Feen A Mint, Fleet Stimulant Laxative, Laxit, Modane, Dulcolax for Women
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet, delayed release

  • 5mg
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Constipation

5-15 mg PO once daily; if complete evacuation required, 30 mg PO once daily

Dosage Forms & Strengths

tablet

  • 5mg
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Constipation

<6 years: PO administration not recommended, because of requirement to swallow tablets

6-12 years: 5 mg or 0.3 mg/kg PO at bedtime or before breakfast 

>12 years: 5-15 mg PO at bedtime

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Interactions

Interaction Checker

and bisacodyl

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal cramping

            Electrolyte and fluid imbalance

            Excessive diarrhea

            Nausea

            Rectal burning

            Vertigo

            Vomiting

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            Warnings

            Contraindications

            Hypersensitivity

            Obstruction or severe impaction

            Symptoms of appendicitis or acute surgical abdomen

            Vomiting

            Rectal bleeding

            Cautions

            Avoid chronic use; may cause laxative dependence

            Avoid using in patients with gastroenteritis

            Do not chew tablet; swallow whole

            Not for use within 1 hour of taking antacid or milk

            Not recommended for children < 6 years because of requirement to swallow tablets

            Not to be used for >1 week

            Some dosage forms may contain benzyl alcohol, which has been associated with fatal toxicity in neonates; avoid dosage forms containing benzyl alcohol derivatives in neonates

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            Pregnancy & Lactation

            Pregnancy

            Plasma concentrations of the active metabolite BHPM are low following doses of 10 mg/day for 7 days; short term use is generally considered safe in pregnancy; avoid long term use

            Lactation

            Not detected in excreted milk following administration of 10 mg/day for 7 days; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Irritates smooth muscle of intestine and possibly colonic intramural plexus, thus in turn increasing peristalsis

            Increases intestinal fluid accumulation and laxation by altering water and electrolyte secretion

            Absorption

            Onset: 6-10 hr

            Distribution

            Vd: 289 L

            Elimination

            Half-life: 8 hr

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.