econazole topical (Rx)

Brand and Other Names:Ecoza
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical cream

  • 1%

topical foam

  • 1% (Ecoza)

Tinea Fungal Infections & Cutaneous Candidiasis

Indicated for topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum; also indicated for treatment of cutaneous candidiasis, and in the treatment of tinea versicolor

Tinea pedis, cruris, corporis, versicolor: Apply cream to affected area(s) qDay

Cutaneous candidiasis: Apply cream to affected area(s) BID

Treatment duration

  • Tinea cruris, corporis, versicolor, cutaneous candidiasis: Apply x 2 weeks
  • Tinea pedis: Apply x4 weeks

Interdigital Tinea Pedis

Indicated for interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum

Ecoza: Apply foam topically to affected area(s) qDay x4 weeks

Administration

Continue full treatment duration of regimen even after infection clears to complete therapy

Dosage Forms & Strengths

topical cream

  • 1%

topical foam

  • 1% (Ecoza)

Tinea Fungal Infections & Cutaneous Candidiasis

Indicated for topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum; also indicated for treatment of cutaneous candidiasis, and in the treatment of tinea versicolor

<3 months: Safety and efficacy not established

Tinea pedis, cruris, corporis, versicolor: Apply cream to affected area(s) qDay

Cutaneous candidiasis: Apply cream to affected area(s) BID

Treatment duration

  • Tinea cruris, corporis, versicolor, cutaneous candidiasis: Apply x 2 weeks
  • Tinea pedis: Apply x4 weeks

Interdigital Tinea Pedis

Indicated for interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum

<12 years: Safety and efficacy not established

≥12 years (Ecoza): Apply foam topically to affected area(s) qDay x4 weeks

Administration

Continue full treatment duration of regimen even after infection clears to complete therapy

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Interactions

Interaction Checker

and econazole topical

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

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                Monitor Closely (1)

                • warfarin

                  econazole topical increases effects of warfarin by decreasing metabolism. Use Caution/Monitor. Most cases reported use of econazole under occlusive bandage, genital application, or application to large body surface area which may increase the systemic absorption.

                Minor (0)

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                  Adverse Effects

                  1-10%

                  Erythema (3%)

                  Frequency Not Defined

                  Burning and stinging sensations

                  Pruritus

                  Postmarketing Reports

                  Application site reaction

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                  Warnings

                  Contraindications

                  Hypersensitivity

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                  Pregnancy & Lactation

                  Pregnancy

                  There are no available data on therapy use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

                  In animal reproduction studies, econazole nitrate did not cause malformation in mice, rabbits and/or rats at oral doses 80 or 40 times the human dermal dose

                  Animal data

                  • Econazole nitrate did not cause malformation in mice, rabbits and/or rats; fetotoxic or embryotoxic effects were observed in oral fertility studies in rats receiving 10 to 40 times the human dermal dose; similar effects were observed in embryofetal and pre- and postnatal developmental studies in mice, rabbits and/or rats receiving oral doses 80 or 40 times human dermal dose

                  Lactation

                  There is no information available on presence of drug in human milk, effects of drug on breastfed infant, or on milk production after topical application of drug to women who are breastfeeding

                  Not known whether product excreted in human milk; because many drugs excreted in human milk, exercise caution when drug administered to a nursing woman

                  Consider developmental and health benefits of breastfeeding along with mother’s clinical need for therapy and any potential adverse effect on breastfed infant from drug or maternal condition

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Fungistatic in action but may be fungicidal in high concentrations or against very susceptible organisms

                  Appears to exert its antifungal and antibacterial activity by altering cellular membranes and interfering with intracellular enzymes

                  Pharmacokinetics

                  Absorbed: minimal

                  Peak Plasma: <1 ng/mL (applied to intact skin); <20 ng/mL (applied to skin stripped of the stratum corneum)

                  Excretion: urine & feces (<1%)

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                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
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                  1 % cream
                  econazole topical
                  -
                  1 % cream
                  econazole topical
                  -
                  1 % cream
                  econazole topical
                  -
                  1 % cream
                  econazole topical
                  -
                  1 % cream
                  econazole topical
                  -
                  1 % cream
                  Ecoza topical
                  -
                  1 % foam

                  Copyright © 2010 First DataBank, Inc.

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                  Patient Handout

                  Patient Education
                  econazole topical

                  ECONAZOLE CREAM - TOPICAL

                  (e-KON-a-zole)

                  COMMON BRAND NAME(S): Spectazole

                  USES: Econazole is used to treat a variety of fungal skin infections such as athlete's foot, jock itch, and ringworm. This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Econazole is an azole antifungal that works by preventing the growth of fungus.

                  HOW TO USE: Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication on and around the affected area as directed by your doctor, usually once or twice a day. The dosage and length of treatment depend on the type of infection being treated. Do not apply this medication more often or use for longer than prescribed.Wash your hands after using unless the area being treated includes the hands. Do not wrap, cover, or bandage the area unless directed to do so by your doctor.Do not apply this medication in the eyes, nose, or mouth, or inside the vagina. If you do get the medication in those areas, flush with plenty of water.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.Tell your doctor if your condition lasts after 2 weeks of treatment (or after 4 weeks of treatment for athlete's foot) or if it gets worse.

                  SIDE EFFECTS: Burning, stinging, irritation, or redness at the application site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                  PRECAUTIONS: Before using econazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (such as clotrimazole, ketoconazole, miconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

                  DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

                  OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                  NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.When treating pityriasis, this medication may not cause a return to normal skin color right away. It may take several months after treatment is completed for your natural skin color to return.

                  MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                  STORAGE: Store at room temperature. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

                  Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

                  IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.