Dosing & Uses
Familial Adenomatous Polyposis
Pending FDA approval to delay the need for major surgeries in the colon, rectum or surgical pouch owing to familial adenomatous polyposis (FAP)
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Pharmacology
Mechanism of Action
Eflornithine: Irreversibly inhibits ornithine decarboxylase (ODC), an enzyme that catalyzes biosynthesis of intracellular polyamines required for cell division and differentiation
Sulindac: Nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
