epinastine (Rx)

Brand and Other Names:Elestat
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.05%

Allergic Conjunctivitis

Instill 1 gtt in affected eye(s) q12hr; continue throughout period of exposure even in absense of symptoms

Dosage Forms & Strengths

ophthalmic solution

  • 0.05%

Allergic Conjunctivitis

<2 years: Safety and efficacy not established

>2 years: As adults, instill 1 gtt in affected eye(s) q12hr

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Adverse Effects

Frequency Not Defined

Headache

Burning sensation in eye

Folliculosis

Hyperemia

Pruritus

Nonocular infection

Postmarketing Reports

Increased lacrimation

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Warnings

Contraindications

Hypersensitivity

Contact lens-related irritation

Cautions

Do not wear contact lenses if eyes are red; wait 10 min after epinastine to insert contacts

Keratitis may occur from inadvertent contamination of multi-dose ophthalmic solution; use caution

Not for contact lens irritation relief

Do not wear contact lenses if eye is red

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Histamine H1 antagonist, inhibits vascular permeability and release of histamine and other mediators involved in allergic response; has affinity for H2 alpha1, alpha2, and 5HT2 receptors

Absorption

Onset: 3-5 min

Duration: 8 hr

Distribution

Protein Bound: 64%

Elimination

Half Life: 12 hr

Total Body Clearance: 56 L/hr

Excretion: Urine 55%; feces 30%

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
epinastine ophthalmic (eye)
-
0.05 % drops
epinastine ophthalmic (eye)
-
0.05 % drops
epinastine ophthalmic (eye)
-
0.05 % drops
epinastine ophthalmic (eye)
-
0.05 % drops

Copyright © 2010 First DataBank, Inc.

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Patient Handout

Patient Education
epinastine ophthalmic (eye)

EPINASTINE - OPHTHALMIC

(EP-i-NAS-teen)

COMMON BRAND NAME(S): Elestat

USES: This medication is an antihistamine used to prevent itching of the eyes caused by allergies (allergic conjunctivitis).

HOW TO USE: This medication is used in both eyes, usually twice daily; or as directed by your doctor. Use should continue during times when you may be exposed to the agents (such as allergens, pollens) that can cause allergic conjunctivitis, even if your eyes are not irritated or itchy.If you wear contact lenses, remove them before applying this medication. Wait at least 10 minutes after using the drops before wearing your lenses again.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and instill the prescribed number of drops. Look downward and gently close your eye for 1 to 2 minutes. Place one finger at the inside corner of the eye and apply gentle pressure to prevent the medication from draining out. Try not to blink and do not rub your eye.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (such as drops or ointments), wait at least 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

SIDE EFFECTS: Burning, redness, or headache may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using epinastine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.If you wear contact lenses, consult your doctor about the use of contact lenses when the eyes are red or irritated.This drug may cause temporary blurred vision after you apply it. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other eye medications.This document does not contain all possible interactions. Before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised January 2022. Copyright(c) 2022 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.