tezacaftor/ivacaftor/elexacaftor (Pending FDA Approval)

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Dosing & Uses

AdultPediatric

Cystic Fibrosis

Pending FDA approval for cystic fibrosis

Cystic Fibrosis

Pending FDA approval for cystic fibrosis

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Pharmacology

Mechanism of Action

Elexacaftor: Next generation CFTR corrector

Tezacaftor: CFTR corrector; increases amount of mature CFTR protein at the cell surface by targeting the processing and trafficking defect of the F508del CFTR protein

Ivacaftor: CFTR potentiator; enhances function of the CFTR protein once it reaches the cell surface

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.