calcium acetate (Rx)

Brand and Other Names:Eliphos, PhosLo, more...Phoslyra, Calphron
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

capsule/tablet

  • 667mg (169mg elemental Ca)

oral solution

  • 667mg/5mL (169mg/5mL elemental Ca)

Hyperphosphatemia in End Stage Renal Failure (On Dialysis)

Initial: 2 capsules (1334 mg) PO with each meal

Increase dose to bring serum phosphate value <6 mg/dL as long as hypercalcemia does not develop

Usual Dose: 3-4 capsules (2001-2868 mg) PO with each meal

Other Information

Do not give additional calcium supplements

Safety and efficacy not established

Hyperphosphatemia in end stage renal failure (on dialysis)

Initial: 2 capsules (1334 mg) PO with each meal

Increase dose to bring serum phosphate value <6 mg/dL as long as hypercalcemia does not develop

Usual dose: 3-4 capsules (2001-2868 mg) PO with each meal

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Interactions

Interaction Checker

and calcium acetate

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            Adverse Effects

            Frequency Not Defined

            Arrhythmias

            Hypomagnesemia

            Hypophosphatemia

            Hypotension

            Nausea

            Pruritus (rare)

            Weakness

            Hypercalcemia

            • Anorexia
            • Coma
            • Confusion
            • Delirium
            • Headache
            • Nausea
            • Vomiting
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            Warnings

            Contraindications

            Hypersensitivity, renal calculi, hypercalcemia, hypophosphatemia, concurrent calcium supplements

            Cautions

            Pregnancy

            Constipation may occur

            Cardiac glycosides; hypercalcemia may aggravate digitalis toxicity

            Advise patients to limit intake of oxalate-rich foods (soy, green leafy vegetables, animal protein) to avoid Ca-Oxalate formation

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            Pregnancy & Lactation

            Pregnancy Category: C

            Maintenance of normal serum calcium levels is important for maternal and fetal well being; hypercalcemia during pregnancy may increase risk for maternal and neonatal complications(eg, stillbirth, preterm delivery, neonatal hypocalcemia and hypoparathyroidism);calcium acetate treatment, as recommended, is not expected to harm a fetus if maternal calcium levels are properly monitored during and following treatment

            Lactation: unknown

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Chelates phosphate (& other anions, eg, oxalate) in intestine to form insoluble calcium phosphate, which is excreted in feces.

            Pharmacokinetics

            Absorption: 30-40%; however it is the unabsorbed drug that binds and removes phosphate

            Excretion: Feces and urine (20%)

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.