Dosing & Uses
Dosage Forms & Strengths
ophthalmic solution
- 0.05%
Allergic Conjunctivitis
January 29, 2019: Manufacturer announced permanent discontinuation
1 gtt in affected eye(s); not to exceed q6hr
Dosage Forms & Strengths
ophthalmic solution
- 0.05%
Allergic Conjunctivitis
January 29, 2019: Manufacturer announced permanent discontinuation
<3 years: Safey and efficacy not established
≥3 years: As adults; 1 gtt in affected eye(s); not to exceed q6hr
Adverse Effects
>10%
Headache (11%)
Frequency Not Defined
Blurred vision
Corneal infiltrates
Corneal staining
Dry eye
Foreign body sensation
Keratitis
Ocular burning or stinging
Ocular discomfort
Ocular hyperemia
Ocular pruritus
Tearing
Abnormal dreams
Asthenia
Bad taste
Dermatitis
Rhinitis
Sinusitis
Warnings
Contraindications
Hypersensitivity
Contact lens-related irritation
Cautions
Do not wear contact lenses if eyes are red; wait 15 min after emedastine to insert contacts
Keratitis may occur from multi-dose ophthalmic solutions due to inadvertent contamination
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Not known if excreted in milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Histamine H1 antagonist, inhibits vascular permeability and release of histamine and other mediators involved in allergic response
Pharmacokinetics
Absorption: Extremely low systemic exposure
Half-Life: 3-4 hr
Metabolism: Liver