Methyclothiazide dosing, indications, interactions, adverse effects, and more.

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Sections methyclothiazide
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

2.5mg
5mg

Hypertension

2.5-5 mg PO qDay; if not controlled after 8-12 weeks, consider adding another antihypertensive agent

Edema

Indicated to relieve edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy

2.5 mg PO qDay; if needed, may increase, not to exceed 10 mg PO qDay

Renal Impairment

Contraindicated in anuria

Use with renal impairment may cause azotemia

Safety and efficacy not established

Interaction Checker

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Contraindicated

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Body as a whole: Headache, cramping, weakness

Cardiovascular: Orthostatic hypotension

Gastrointestinal: Pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation, anorexia

Hematologic: Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia

Hypersensitivity Reactions: Anaphylactic reactions, necrotizing angiitis (vasculitis, cutaneous vasculitis), Stevens-Johnson syndrome, respiratory distress including pneumonitis and pulmonary edema, fever, purpura, urticaria, rash, photosensitivity

Metabolic and Nutritional Disorders: Hyperglycemia, hyperuricemia, electrolyte imbalance

Neurologic: Vertigo, dizziness, paresthesias, muscle spasm, restlessness

Special senses: Transient blurred vision, xanthopsia

Urogenital: Glycosuria

Contraindications

Hypersensitivity to methyclothiazide or sulfonamide-derivatives

Anuria

Cautions

Rare cases of sensitivity reactions have occurred with history of allergy or bronchial asthma

May cause hypokalemia

Fluid/electrolyte imbalance may occur

Caution with renal disease or significant impairment of renal function, since azotemia may occur

Hyponatremia/hypochloremia: Caution with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma

Possibility of exacerbation or activation of systemic lupus erythematosus has been reported

May precipitate hyperuricemia or frank gout

Latent diabetes mellitus may become manifest during thiazide administration

May cause increased concentrations of total serum cholesterol, total triglycerides, and low-density lipoproteins in some patients

May decrease urinary calcium excretion

Antihypertensive effects enhanced in postsympathectomy patient

Pregnancy & Lactation

Pregnancy Category: B; diuretics not recommended during pregnancy

Lactation: Distributed in breast milk; diuresis may affect breast milk production; not recommended

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Absorption: rapid oral absorption

Onset of action: 2 hr

Peak effect: 6 hr

Duration of action: 24 hr

Excretion: urine; primarily as inactive metabolite

Mechanism of Action

Thiazide diuretic; inhibits renal tubular reabsorption of electrolytes; sodium and chloride excretion is greatly enhanced; potassium excretion also enhanced

Images

Patient Handout

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections methyclothiazide
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

methyclothiazide (Rx)