etrasimod (Pending FDA Approval)

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Dosing & Uses

Ulcerative Colitis

Pending FDA approval for adults with moderately-to-severely active ulcerative colitis (UC)

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Pharmacology

Mechanism of Action

Sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptors 1, 4, and 5

Blocks capacity of lymphocytes to regress from lymph nodes, reducing number of lymphocytes in peripheral blood to decrease inflammation

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.