Dosing & Uses
Dosage Forms & Strengths
vaginal cream
- 2%
Candidiasis
Gynazole: 1 applicatorful of cream (approximately 5 g of the cream) intravaginally as single dose; may need to extend use for 6 days in pregnant women (2nd and 3rd trimester only)
Safety & efficacy not established
Adverse Effects
Frequency Not Defined
Pelvic/abdominal pain or cramping
Vulvar/vaginal irritation, soreness, and swelling
Warnings
Contraindications
Hypersensitivity to drug
1st trimester of pregnancy
Cautions
Hypersensitivity to other azoles
Contains mineral oil, which may weaken latex or rubber products
Consider HIV infection in sexually active women with difficult to eradicate recurrent yeast infection
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Imidazole; alters fungal cell membrane permeability
Peak Plasma Time: 12-24 hr
Absorption: systemic (1.7%)
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
