Suggested Dosing
Eczema, Atopic
4-6 g PO daily
Mastalgia
3-4 g PO daily
Premenstrual Syndrome
2-4 g PO daily
Rheumatoid Arthritis
540 mg-2.8 g PO daily
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Suggested Uses
CAD, eczema (atopic), endometriosis, GI disorders, hypercholesterolemia, intermittent claudication, mastalgia, menopausal symptoms, osteoporosis, premenstrual syndrome, rheumatoid arthritis
Efficacy
Possibly effective for PMS, mastalgia, osteoporosis
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Adverse Effects
Frequency Not Defined
Headache
Indigestion
Nausea
Pregnancy complications
Soft stools
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Warnings
Contraindications
None Reported
Cautions
Bleeding disorders, concomitant anesthesia, schizophrenia, seizure disorder
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Pregnancy & Lactation
Pregnancy Category: X
Lactation: unsafe
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Previous
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Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Gamma-linolenic acid (GLA) metabolized to anti-inflammatory prostaglandins
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
