Fluoracaine (fluorescein/proparacaine ophthalmic) dosing, indications, interactions, adverse effects, and more.

Sections

Sections fluorescein/proparacaine ophthalmic
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

fluorescein/proparacaine ophthalmic

ophthalmic solution

0.25/0.5%

Ophthalmic Anesthesia

Provides topical ophthalmic anesthesia with a disclosing agent for short corneal and conjunctival procedures

1 drop in each eye q 5-10 minutes x5-7 doses

Other Information

Use of an eye patch is recommended

Safety and efficacy not established

Frequency Not Defined

Transient local stinging

Transient local burning

Conjunctival redness

Severe, immediate allergic corneal reaction (rare)

Allergic contact dermatitis (rare)

Conjunctival congestion (rare)

Conjunctival hemorrhage (rare)

Contraindications

Hypersensitivity to either component or to similar drugs

Cautions

Prolonged use not recommended as may diminish duration of anesthesia, retard wound healing, and cause corneal infection and/or opacification with accompanying permanent visual loss or corneal perforation

Systemic toxicity (CNS stimulation followed by CNS and cardiovascular depression) possible but rare

Protection of the eye from other irritating chemicals, foreign bodies, and rubbing during the period of anesthesia is very important

Use cautiously and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism

Pregnancy & Lactation

Pregnancy Category: C Administer in pregnancy only if clearly needed

Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Onset: 30 sec

Duration: 10-20 min

Mechanism of Action

Fluorescein sodium: contact with aqueous humor increases intensity of green fluorescence

Proparacaine hydrochloride: topical anesthetics stabilize neuronal membrane so neuron is less permeable to ions, preventing initiation and transmission of nerve impulses, producing local anesthetic action

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections fluorescein/proparacaine ophthalmic
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

fluorescein/proparacaine ophthalmic (Rx)