Suggested Dosing
Chemotherapy Adjunct
600 mg/day IM days 2-5 of chemotherapy
1.5 g/m² IV before chemotherapy
Male Infertility
600 mg IM qOD x 2 months
Oral
250 mg PO qDay
Dose range: 50-600 mg/day
Inhaled
600 mg NEB BID
Inborn Errors of Metabolism of Glutathione (Orphan)
Liposomal glutathione: Support of glutathione deficiency in individuals with inborn errors of metabolism of glutathione (IEMG)
Orphan indication sponsor
- Your Energy Systems, LLC; 555 Bryant Street #305; Palo Alto, CA 94301
Cystic Fibrosis (Orphan)
S-Nitroglutathione: Management of cystic fibrosis to improve airway clearance and to improve or stabilize pulmonary function
Orphan indication sponsor
- N30 PHARMAceuticals, LLC; 3122 Sterling Circle; Boulder, CO 80301
Lung Dysfunction (Orphan)
Orphan designation for treatment of lung dysfunction following lung transplant
Sponsor
- Renovion, Inc; 2 Briar Bridge Lane, Chapel Hill, NC
Suggested Uses
Male infertility (IM use), atherosclerosis (IV, PO use), cancers, chemotherapy adjunct (IM, IV use), diabetes (IV use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, Parkinson's disease (IV, PO use)
Efficacy
Possibly effective for chemotherapy toxicity
Adverse Effects
Bronchospasm (inhaled use)
Warnings
Contraindications
Asthma (inhaled use)
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Powerful antioxidant; co-factor in Phase I hepatic detoxification; involved in synthesis of DNA & proteins, amino acid transport, enzyme activation, immune system function
