gentamicin ophthalmic (Rx)

Brand and Other Names:Garamycin Ophthalmic, Genoptic, more...Gentak
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution/ointment

  • 0.3%

Conjunctivitis & Postoperative Prophylaxis

Apply 1/2 inch BID-TID (ointment); 1-2 gtt q2-4hr PRN (soln), if severe up to 2gtt q1hr

Used in keratitis in FORTIFIED preparation from injectable (instead of 3 mg/mL, used in 10-15 mg/mL concentration); very effective in q15-30min interval, reduce q1hr in 24-48hr as determined clinically

See also combo with prednisolone

Dosage Forms & Strengths

ophthalmic solution/ointment

  • 0.3%

Conjunctivitis & Postoperative Prophylaxis

Apply 1/2 inch BID-TID (ointment); 1-2 gtt q2-4hr PRN (soln), if severe up to 2gtt q1hr

Used in keratitis in FORTIFIED preparation from injectable (instead of 3 mg/mL, used in 10-15 mg/mL concentration); very effective in q15-30min interval, reduce q1hr in 24-48hr as determined clinically

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Adverse Effects

Frequency Not Defined

Contain other ingredients such as parabens which may also cause allergic contact dermatitis

Transient irritation, burning, stinging

Increased redness, lacrimation

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Warnings

Contraindications

Hypersensitivity to aminoglycosides or any component of product

Cautions

Prolonged use of topical antibiotics may give rise to overgrowth of nonsusceptible organisms including fungi

Bacterial resistance to drug may also develop with long term use; if purulent discharge, inflammation or pain becomes aggravated, the patient should discontinue use of medication and consult a physician

If irritation or hypersensitivity to any component of the drug develops, the patient should discontinue use of this preparation and appropriate therapy instituted

Ophthalmic ointments may retard corneal healing

To avoid contamination, do not touch tip of container to eye, eyelid or any surface

Not to be used as routine prophylaxis for ophthalmia neonatorum; severe ocular reactions described as eyelid erythema, periocular blistering and ocular discharge reported within 48 hr after administration

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: safety in nursing infants unknown

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Absorption: into aqueous humor; greatest when cornea is abraded

Mechanism of Action

Appears to inhibit protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
gentamicin ophthalmic (eye)
-
0.3 % drops
gentamicin ophthalmic (eye)
-
0.3 % drops
gentamicin ophthalmic (eye)
-
0.3 % drops
gentamicin ophthalmic (eye)
-
0.3 % drops
Gentak ophthalmic (eye)
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0.3 % (3 mg/gram) ointment
gentamicin injection
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40 mg/mL vial
gentamicin injection
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40 mg/mL vial
gentamicin injection
-
20 mg/2 mL vial
gentamicin injection
-
40 mg/mL vial
gentamicin topical
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0.1 % ointment
gentamicin topical
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0.1 % cream
gentamicin topical
-
0.1 % cream
gentamicin topical
-
0.1 % ointment
gentamicin topical
-
0.1 % cream
gentamicin topical
-
0.1 % cream
gentamicin topical
-
0.1 % ointment
gentamicin topical
-
0.1 % ointment
gentamicin topical
-
0.1 % cream
gentamicin topical
-
0.1 % ointment
gentamicin topical
-
0.1 % cream
gentamicin topical
-
0.1 % ointment

Copyright © 2010 First DataBank, Inc.

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Patient Handout

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Patient Education
gentamicin ophthalmic (eye)

GENTAMICIN OINTMENT - OPHTHALMIC

(jen-ta-MYE-sin)

COMMON BRAND NAME(S): Garamycin

USES: This medication is used to treat bacterial infections (such as blepharitis, conjunctivitis) of the eye and the skin around the eyes (such as eyelids). It is also used to prevent infection after eye injury or surgery. It belongs to a class of drugs known as aminoglycoside antibiotics. Gentamicin works by killing the bacteria.This medication treats only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.This drug should not be used in newborns due to an increased risk of serious side effects.

HOW TO USE: To apply eye ointment, wash your hands first. To avoid contamination, be careful not to touch the tip of the tube or let it touch your eye, eyelid, or any other surface. Apply to the eyes only. Do not swallow or inject.Do not wear contact lenses while you are using this medication. Sterilize contact lenses according to the manufacturer's directions, and check with your doctor before you begin using them again.To apply eye ointments, tilt your head back, look up, and gently pull down the lower eyelid to make a pouch. Place a half-inch (1.3 centimeters) strip of ointment into the pouch as directed by your doctor. Gently close the eye and roll the eyeball in all directions to spread the medication. Try not to blink and do not rub the eye. Repeat these steps for your other eye if so directed. Wipe the tip of the ointment tube with a clean tissue to remove extra medication before recapping it. Wait several minutes for your vision to clear before driving or operating machinery.The dosage is based on your medical condition and response to treatment. Your doctor may direct you to use this medication more often at first, then use it less frequently as the infection improves. Do not increase your dose or use it more often than directed. Your doctor may prescribe gentamicin drops for use during the day and gentamicin ointment at bedtime.If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed. Stopping the medication too soon may allow the bacteria to continue to grow, which may result in a return of the infection.Tell your doctor if your condition persists or worsens.

SIDE EFFECTS: Eye stinging/burning/redness or temporary blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Use of this medication for prolonged or repeated periods may result in other types of eye infections, including fungal infections. Stop using this medication and contact your doctor if you notice new or worsening eye symptoms (such as pain, swelling, thick discharge or pus).Rarely, gentamicin products used in the eye may be absorbed and may cause serious side effects. Tell your doctor right away if any of these rare but serious side effects occur: easy bruising/bleeding, mental/mood changes (such as hallucinations).A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using gentamicin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as tobramycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: contact lens use.After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This drug may pass into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.