Suggested Dosing
Osteoarthritis, Knee
Freeze-dried aqueous extract: 100 mg PO qDay
Rheumatoid Arthritis
Extract free of tetracyclic oxindole alkaloids: 60 mg PO TID
Suggested Uses
Arthritis, birth control, bone pains, cancer (urinary tract), intestinal disorders, kidney cleansing, peptic ulcers, viral infections, wound healing, allergic rhinitis, diverticulitis, Alzheimer's disease, and leaky bowel syndrome, herpes simplex, human immunodeficiency virus, CFS
Efficacy
Osteoarthritis: Freeze-dried Uncaria guianensis PO decreases pain related to physical activity. Does not decrease pain at rest or swelling
Rheumatoid arthritis: Uncaria tomoentosa extract PO modestly improves symptoms
Insufficient reliable results for other listed uses
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (5)
- adalimumab
cat's claw, adalimumab. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible additive immunosuppr'n.
- anakinra
cat's claw, anakinra. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible additive immunosuppr'n.
- etanercept
cat's claw, etanercept. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible additive immunosuppr'n.
- infliximab
cat's claw, infliximab. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible additive immunosuppr'n.
- tocilizumab
cat's claw, tocilizumab. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Possible additive immunosuppr'n.
Adverse Effects
Dizziness, headache, hypotension, vomiting
Warnings
Contraindications
Autoimmune disorders, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus
Cautions
Concurrent antihypertensives, concurrent CYP3A4 substrates, concurrent immunosupressant therapy, hypotension
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Decreases inflammation via inhibition of NF-kappa b & TNFalpha
Enhances immune function via increase in WBCs
Mytraphylline: diuretic effect
Quinovic acid glycosides: antiviral activity (in vitro)
