gefapixant (Pending FDA Approval)

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Dosing & Uses

Chronic Cough

Pending FDA approval for chronic cough

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Pharmacology

Mechanism of Action

P2X3 receptor antagonist; purinergic receptor P2X3 is an ATP-gated ion channel found on sensory nerve fibers, predominantly C fibers, in the airway lining

Chemical stimuli, including adenosine triphosphate (ATP), can be released from airway lining cells due to processes including airway inflammation, irritation, and mechanical stress/injury; binding of extracellular ATP to P2X3 receptors on C fibers in the airway can be sensed as a signal of potential damage, creating an action potential, which may initiate coughing

Blockade of extracellular ATP binding to P2X3 receptors is thought to reduce sensory C fiber activation and subsequently, coughing

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.