Dosing & Uses
AdultPediatric
See pediatric indications
Duchenne Muscular Dystrophy
Pending FDA approval for Duchenne muscular dystrophy (DMD)
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Pharmacology
Mechanism of Action
Inhibits histone deacetylases (HDACs)
HDACs are enzymes that prevent gene translation by changing the three-dimensional folding of DNA in cells; higher than normal HDAC activity in individuals with Duchenne muscular dystrophy may prevent muscle regeneration and also trigger inflammation
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
