Dosing & Uses
Dosage Forms & Strengths
suppositories
- 1g
- 1.5g
- 2g
- 2.1g
- 2.8g
Constipation
2-2.8 g suppository, retain 15 min, PRN constipation OR
Administration
Patient should lie on left side with knees bent
Remove protective wrap before inserting
Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)
For liquid suppository, squeeze bulb until all liquid is expelled and discard unit
Dosage Forms & Strengths
suppositories
- 1g
- 1.5g
- 2g
- 2.1g
- 2.8g
Constipation
2-6 years
- 1-1.7 g suppository, retain 15 min, PRN constipation
>6 years
- 2-8 g suppository, retain 15 min, PRN constipation
Adverse Effects
Frequency Not Defined
Excessive bowel activity
Cramping pain
Rectal irritation
Tenesmus
Warnings
Contraindications
GI obstruction, severe impaction
Cautions
For rectal use only
May cause rectal discomfort of burning sensation
Do not use when abdominal pain, nausea, after experiencing a sudden change in bowel habits lasting more than 2 weeks, if already used laxative for more than a 1 week, or vomiting present (unless directed by physician)
Frequent or prolonged use of laxatives may result in dependence
Stop use if experience rectal bleeding or no bowel movement after using product, rectal bleeding, or failure to have bowel movement; these may require physician care
Do not use for longer than 1 wk
Pregnancy & Lactation
Pregnancy Category: Data not available
Lactation: Not known whether excreted in breast milk; no risks shown to nursing infants
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Hyperosmotic dehydrating agent; draws fluid into colon, increases osmotic pressure, and stimulates evacuation
Pharmacokinetics
Onset of action: 15-30 min
Absorption: Poorly absorbed