glycerin (OTC)

Frequency Not Defined

Excessive bowel activity

Cramping pain

Rectal irritation

Tenesmus

Contraindications

GI obstruction, severe impaction

Cautions

For rectal use only

May cause rectal discomfort of burning sensation

Do not use when abdominal pain, nausea, after experiencing a sudden change in bowel habits lasting more than 2 weeks, if already used laxative for more than a 1 week, or vomiting present (unless directed by physician)

Frequent or prolonged use of laxatives may result in dependence

Stop use if experience rectal bleeding or no bowel movement after using product, rectal bleeding, or failure to have bowel movement; these may require physician care

Do not use for longer than 1 wk

Pregnancy Category: Data not available

Lactation: Not known whether excreted in breast milk; no risks shown to nursing infants

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Hyperosmotic dehydrating agent; draws fluid into colon, increases osmotic pressure, and stimulates evacuation

Pharmacokinetics

Onset of action: 15-30 min

Absorption: Poorly absorbed