Granulex, Xenaderm (castor-oil-trypsin) dosing, indications, interactions, adverse effects, and more

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Sections castor oil/trypsin
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

castor oil / trypsin

ointment

(788mg/g)/(90USP)

spray/aerosol

(788mg/g)/(0.12mg)
(650mg/g)/(0.1mg)

Treatment of Skin Ulcers & Wound Healing

Ointment: Apply thin film q12hr or more often PRN

Spray/aerosol: Apply q12hr or more often PRN

Administration

May be left undressed or bandaged with appropriate dressing

Safety & efficacy not established

Interaction Checker

Enter a drug name and castor oil/trypsin

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Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (2)

deflazacort
castor oil and deflazacort both decrease serum potassium. Use Caution/Monitor.
silver nitrate
silver nitrate decreases effects of trypsin by Other (see comment). Use Caution/Monitor. Comment: Heavy metal ions inactivate enzymes.

Minor (0)

Frequency Not Defined

Transient "burning" sensation upon application

Skin irritation

Contraindications

Hypersensitivity

Cautions

Do not use on fresh arterial clots

Avoid spraying on eyes

Do not expose areosol formulation to flame or high temperatures

Spray is flammable

In presence of zinc or hemoglobin deficiency wound healing may be delayed

Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Trypsin digests proteins in necrotic tissue

Balsam component stimulates capillary bed & improves circulation in the wound area

Castor oil promotes reepithelialization and helps reduce pain

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections castor oil/trypsin
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

castor oil/trypsin (Rx)