Dosing & Uses
Dosage Forms & Strengths
castor oil / trypsin
ointment
- (788mg/g)/(90USP)
spray/aerosol
- (788mg/g)/(0.12mg)
- (650mg/g)/(0.1mg)
Treatment of Skin Ulcers & Wound Healing
Ointment: Apply thin film q12hr or more often PRN
Spray/aerosol: Apply q12hr or more often PRN
Administration
May be left undressed or bandaged with appropriate dressing
Safety & efficacy not established
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (2)
- deflazacort
castor oil and deflazacort both decrease serum potassium. Use Caution/Monitor.
- silver nitrate
silver nitrate decreases effects of trypsin by Other (see comment). Use Caution/Monitor. Comment: Heavy metal ions inactivate enzymes.
Minor (0)
Adverse Effects
Frequency Not Defined
Transient "burning" sensation upon application
Skin irritation
Warnings
Contraindications
Hypersensitivity
Cautions
Do not use on fresh arterial clots
Avoid spraying on eyes
Do not expose areosol formulation to flame or high temperatures
Spray is flammable
In presence of zinc or hemoglobin deficiency wound healing may be delayed
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Trypsin digests proteins in necrotic tissue
Balsam component stimulates capillary bed & improves circulation in the wound area
Castor oil promotes reepithelialization and helps reduce pain
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Formulary
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