castor oil/trypsin (Rx)

Brand and Other Names:Granulex, Xenaderm, more...Optase

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

castor oil / trypsin

ointment

  • (788mg/g)/(90USP)

spray/aerosol

  • (788mg/g)/(0.12mg)
  • (650mg/g)/(0.1mg)

Treatment of Skin Ulcers & Wound Healing

Ointment: Apply thin film q12hr or more often PRN

Spray/aerosol: Apply q12hr or more often PRN

Administration

May be left undressed or bandaged with appropriate dressing

Safety & efficacy not established

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Interactions

Interaction Checker

and castor oil/trypsin

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (2)

                • deflazacort

                  castor oil and deflazacort both decrease serum potassium. Use Caution/Monitor.

                • silver nitrate

                  silver nitrate decreases effects of trypsin by Other (see comment). Use Caution/Monitor. Comment: Heavy metal ions inactivate enzymes.

                Minor (0)

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                  Adverse Effects

                  Frequency Not Defined

                  Transient "burning" sensation upon application

                  Skin irritation

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Cautions

                  Do not use on fresh arterial clots

                  Avoid spraying on eyes

                  Do not expose areosol formulation to flame or high temperatures

                  Spray is flammable

                  In presence of zinc or hemoglobin deficiency wound healing may be delayed

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: N/A

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Trypsin digests proteins in necrotic tissue

                  Balsam component stimulates capillary bed & improves circulation in the wound area

                  Castor oil promotes reepithelialization and helps reduce pain

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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

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                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.