clotrimazole (Rx, OTC)

Brand and Other Names:Gyne-Lotrimin-3 Combination Pack, Gyne-Lotrimin-3 Vaginal Cream, more...Gyne-Lotrimin-3 Vaginal Suppositories, Gyne-Lotrimin-7, Mycelex-7, Mycelex-7 Combination Pack, Mycelex vaginal
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

troche

  • 10mg

lozenge

  • 10mg
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Candidiasis

Oropharyngeal candidiasis (prophylaxis)

  • 10 mg PO slowly dissolved in mouth tid or until steroids reduced to maintenance levels

Opharyngeal candidiasis (treatment)

  • 10 mg PO slowly dissolved in mouth 5 times daily for 14 consecutive days; when used for initial HIV-1 treatment,  duration is typically 7-14 days

Pouchitis (Orphan)

Topical treatment of children and adults with pouchitis

Orphan indication sponsor

  • Atlantic Healthcare LTD; Maple House: Halsted, Essex CO9 4BB, UK

Dosage Forms & Strengths

troche

  • 10mg

lozenges

  • 10mg
more...

Candidiasis

<3 years

  • Safety and efficacy not established

>3 years

  • Oropharyngeal candidiasis (prophylaxis): 10 mg PO slowly dissolved in mouth tid or until steroids reduced to maintenance levels
  • Oropharyngeal candidiasis (treatment): 10 mg PO slowly dissolved in mouth 5 times daily for 14 consecutive days; when used for initial HIV-1 treatment, duration is typically 7-14 days

Pouchitis (Orphan)

Topical treatment of children and adults with pouchitis

Orphan indication sponsor

  • Atlantic Healthcare LTD; Maple House: Halsted, Essex CO9 4BB, UK
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Interactions

Interaction Checker

and clotrimazole

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Abnl LFTs

            1-10%

            Nausea/vomiting (troches)

            Mild burning, irritation, stinging to skin or vaginal area (vaginal tabs/cream)

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Abnormal LFTs reported, including abnormal aspartate aminotransferase reported; monitor LFTs periodically, especially in patients with hepatic impairment

            Use caution; abnormal LFTs reported; elevation usually minimal; monitor LFTs periodically

            Not for treatment of systemic fungal infections

            For maximum efficacy, must dissolve dosage form in mouth

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Alters Candida cell membrane permeability; binds to phospholipids in fungal cell membrane, which alters cell wall permeability and results in the loss of intracellular elements; fungistatic and fungicidal

            Absorption

            Peak plasma time

            • Oral: Salivary levels occur within 3 hr following 30 min of dissolution time
            • Vaginal cream: High vaginal levels, 8-24 hr
            • Vaginal tablet: High vaginal levels, 1-2 d

            Elimination

            Excretion: Feces (as metabolites)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.