Dosing & Uses
Dosage Forms & Strengths
oral liquid
- 0.5mg/mL (Histex)
- 0.625mg/mL (Vanahist PD, M-Hist PD)
Allergic Rhinitis
Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis
Histex: 2.5 mg (5 mL) PO q6hr
Vanahist PD or M-Hist PD: 2.5 mg (4 mL) PO q6hr
Dosage Forms & Strengths
oral liquid
- 0.5mg/mL (Histex)
- 0.625mg/mL (Vanahist PD, M-Hist PD)
- 0.938mg/mL (Histex PD Drops)
- 0.313mg/mL (Vanaclear PD)
Allergic Rhinitis
Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis
Histex
- <6 years: As directed by physician
- 6 to <12 years: 1.25 mg (2.5 mL) PO q6hr prn
- ≥12 years: 2.5 mg (5 mL) PO q6hr
Vanahist PD or M-Hist PD
- <6 years: As directed by physician
- 6 to <12 years: 1.25 mg (2 mL) PO q6hr prn
- ≥12 years: 2.5 mg (4 mL) PO q6hr
Histex PD Drops
- 4 month to <2 years: 0.313 mg (0.33 mL) PO q4-6 hr; not to exceed 4 doses (1.33 mL) per 24 hr
- 2 to <4 years: 0.626 mg (0.67 mL) PO q4-6 hr; not to exceed 4 doses (2.67 mL) per 24 hr
- 4 to <6 years: 0.938 mg (1 mL) PO q4-6 hr; not to exceed 4 doses (4 mL) per 24 hr
Vanaclear PD
- 4 month to <2 years: 0.313 mg (1 mL) PO q4-6 hr; not to exceed 4 doses (4 mL) per 24 hr
- 2 to <4 years: 0.626 mg (2 mL) PO q4-6 hr; not to exceed 4 doses (8 mL) per 24 hr
- 4 to <6 years: 0.938 mg (3 mL) PO q4-6 hr; not to exceed 4 doses (12 mL) per 24 hr
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (6)
- calcium/magnesium/potassium/sodium oxybates
triprolidine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- eluxadoline
triprolidine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.
- metoclopramide intranasal
triprolidine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- olopatadine intranasal
triprolidine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- pitolisant
triprolidine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.
- sodium oxybate
triprolidine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (198)
- acrivastine
acrivastine and triprolidine both increase sedation. Use Caution/Monitor.
- albuterol
triprolidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
triprolidine and alfentanil both increase sedation. Use Caution/Monitor.
- alprazolam
triprolidine and alprazolam both increase sedation. Use Caution/Monitor.
- amifampridine
triprolidine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- amisulpride
amisulpride and triprolidine both increase sedation. Use Caution/Monitor.
- amitriptyline
triprolidine and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
triprolidine and amobarbital both increase sedation. Use Caution/Monitor.
- amoxapine
triprolidine and amoxapine both increase sedation. Use Caution/Monitor.
- arformoterol
triprolidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
triprolidine and aripiprazole both increase sedation. Use Caution/Monitor.
- armodafinil
triprolidine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- asenapine
asenapine and triprolidine both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine transdermal and triprolidine both increase sedation. Use Caution/Monitor.
- avapritinib
avapritinib and triprolidine both increase sedation. Use Caution/Monitor.
- azelastine
azelastine and triprolidine both increase sedation. Use Caution/Monitor.
- belladonna and opium
triprolidine and belladonna and opium both increase sedation. Use Caution/Monitor.
- benperidol
triprolidine and benperidol both increase sedation. Use Caution/Monitor.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen and triprolidine both increase sedation. Use Caution/Monitor.
- benzphetamine
triprolidine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, triprolidine. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
brexpiprazole and triprolidine both increase sedation. Use Caution/Monitor.
- brimonidine
brimonidine and triprolidine both increase sedation. Use Caution/Monitor.
- brivaracetam
brivaracetam and triprolidine both increase sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and triprolidine both increase sedation. Use Caution/Monitor.
- buprenorphine
triprolidine and buprenorphine both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
triprolidine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
- buprenorphine subdermal implant
buprenorphine subdermal implant and triprolidine both increase sedation. Use Caution/Monitor.
- buprenorphine transdermal
buprenorphine transdermal and triprolidine both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
buprenorphine, long-acting injection and triprolidine both increase sedation. Use Caution/Monitor.
- butabarbital
triprolidine and butabarbital both increase sedation. Use Caution/Monitor.
- butalbital
triprolidine and butalbital both increase sedation. Use Caution/Monitor.
- butorphanol
triprolidine and butorphanol both increase sedation. Use Caution/Monitor.
- caffeine
triprolidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and triprolidine both increase sedation. Use Caution/Monitor.
- cenobamate
cenobamate, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor.
- chloral hydrate
triprolidine and chloral hydrate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
triprolidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.
- chlorpromazine
triprolidine and chlorpromazine both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and triprolidine both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and triprolidine both increase sedation. Use Caution/Monitor.
- clobazam
triprolidine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
triprolidine and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
triprolidine and clonazepam both increase sedation. Use Caution/Monitor.
- clorazepate
triprolidine and clorazepate both increase sedation. Use Caution/Monitor.
- clozapine
triprolidine and clozapine both increase sedation. Use Caution/Monitor.
- codeine
triprolidine and codeine both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and triprolidine both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and triprolidine both increase sedation. Use Caution/Monitor.
- daridorexant
triprolidine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desflurane
desflurane and triprolidine both increase sedation. Use Caution/Monitor.
- desipramine
triprolidine and desipramine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.
- dexfenfluramine
triprolidine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
triprolidine and dexmedetomidine both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
triprolidine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
triprolidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
triprolidine and dextromoramide both increase sedation. Use Caution/Monitor.
- diamorphine
triprolidine and diamorphine both increase sedation. Use Caution/Monitor.
- diazepam intranasal
diazepam intranasal, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
- diethylpropion
triprolidine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difelikefalin
difelikefalin and triprolidine both increase sedation. Use Caution/Monitor.
- difenoxin hcl
triprolidine and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and triprolidine both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and triprolidine both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
triprolidine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- dipipanone
triprolidine and dipipanone both increase sedation. Use Caution/Monitor.
- dobutamine
triprolidine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- donepezil transdermal
donepezil transdermal, triprolidine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.
- dopamine
triprolidine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
triprolidine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
triprolidine and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
triprolidine and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
triprolidine and doxylamine both increase sedation. Use Caution/Monitor.
- droperidol
triprolidine and droperidol both increase sedation. Use Caution/Monitor.
- ephedrine
triprolidine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
triprolidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
triprolidine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- esketamine intranasal
esketamine intranasal, triprolidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- estazolam
triprolidine and estazolam both increase sedation. Use Caution/Monitor.
- ethanol
triprolidine and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and triprolidine both increase sedation. Use Caution/Monitor.
- fenfluramine
triprolidine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fentanyl
fentanyl, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl intranasal
fentanyl intranasal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transdermal
fentanyl transdermal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- fentanyl transmucosal
fentanyl transmucosal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
- flibanserin
triprolidine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
- fluphenazine
triprolidine and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
triprolidine and flurazepam both increase sedation. Use Caution/Monitor.
- formoterol
triprolidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- gabapentin
gabapentin, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- gabapentin enacarbil
gabapentin enacarbil, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- ganaxolone
triprolidine and ganaxolone both increase sedation. Use Caution/Monitor.
- glycopyrronium tosylate topical
glycopyrronium tosylate topical, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.
- gotu kola
gotu kola increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- haloperidol
triprolidine and haloperidol both increase sedation. Use Caution/Monitor.
- hawthorn
hawthorn increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- hops
hops increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- hydromorphone
triprolidine and hydromorphone both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.
- iloperidone
triprolidine and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
triprolidine and imipramine both increase sedation. Use Caution/Monitor.
- isoproterenol
triprolidine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- kava
kava increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- ketamine
ketamine and triprolidine both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, triprolidine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- levalbuterol
triprolidine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
triprolidine and levorphanol both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
triprolidine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
triprolidine and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
triprolidine and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
triprolidine and loprazolam both increase sedation. Use Caution/Monitor.
- lorazepam
triprolidine and lorazepam both increase sedation. Use Caution/Monitor.
- lormetazepam
triprolidine and lormetazepam both increase sedation. Use Caution/Monitor.
- loxapine
triprolidine and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
triprolidine and loxapine inhaled both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, triprolidine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
triprolidine and maprotiline both increase sedation. Use Caution/Monitor.
- marijuana
triprolidine and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
triprolidine and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
triprolidine and meperidine both increase sedation. Use Caution/Monitor.
- meprobamate
triprolidine and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
triprolidine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methadone
triprolidine and methadone both increase sedation. Use Caution/Monitor.
- methamphetamine
triprolidine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methylenedioxymethamphetamine
triprolidine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
triprolidine and midazolam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
triprolidine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
triprolidine and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
triprolidine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
triprolidine and morphine both increase sedation. Use Caution/Monitor.
- motherwort
triprolidine and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
triprolidine and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
triprolidine and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
triprolidine and nalbuphine both increase sedation. Use Caution/Monitor.
- norepinephrine
triprolidine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
triprolidine and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
triprolidine and olanzapine both increase sedation. Use Caution/Monitor.
- opium tincture
triprolidine and opium tincture both increase sedation. Use Caution/Monitor.
- oxazepam
triprolidine and oxazepam both increase sedation. Use Caution/Monitor.
- oxycodone
triprolidine and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
triprolidine and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
triprolidine and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
triprolidine and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
triprolidine and papaverine both increase sedation. Use Caution/Monitor.
- passion flower
passion flower increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- pentazocine
triprolidine and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
triprolidine and pentobarbital both increase sedation. Use Caution/Monitor.
- perphenazine
triprolidine and perphenazine both increase sedation. Use Caution/Monitor.
- phendimetrazine
triprolidine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
triprolidine and phenobarbital both increase sedation. Use Caution/Monitor.
- phentermine
triprolidine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
triprolidine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
triprolidine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
triprolidine and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
triprolidine and pimozide both increase sedation. Use Caution/Monitor.
- pirbuterol
triprolidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pregabalin
pregabalin, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- primidone
triprolidine and primidone both increase sedation. Use Caution/Monitor.
- prochlorperazine
triprolidine and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and triprolidine both increase sedation. Use Caution/Monitor.
- propofol
propofol and triprolidine both increase sedation. Use Caution/Monitor.
- propylhexedrine
triprolidine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
triprolidine and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
triprolidine and quazepam both increase sedation. Use Caution/Monitor.
- quetiapine
triprolidine and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
triprolidine and ramelteon both increase sedation. Use Caution/Monitor.
- risperidone
triprolidine and risperidone both increase sedation. Use Caution/Monitor.
- salmeterol
triprolidine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
triprolidine and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
triprolidine and secobarbital both increase sedation. Use Caution/Monitor.
- sevoflurane
sevoflurane and triprolidine both increase sedation. Use Caution/Monitor.
- shepherd's purse
triprolidine and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
triprolidine and sufentanil both increase sedation. Use Caution/Monitor.
- tapentadol
triprolidine and tapentadol both increase sedation. Use Caution/Monitor.
- temazepam
triprolidine and temazepam both increase sedation. Use Caution/Monitor.
- terbutaline
triprolidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
triprolidine and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
triprolidine and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
triprolidine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
triprolidine and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
triprolidine and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
triprolidine and triazolam both increase sedation. Use Caution/Monitor.
- triclofos
triprolidine and triclofos both increase sedation. Use Caution/Monitor.
- trifluoperazine
triprolidine and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
triprolidine and trimipramine both increase sedation. Use Caution/Monitor.
- valerian
valerian increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
- xylometazoline
triprolidine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
triprolidine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
triprolidine and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
triprolidine and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
triprolidine and zotepine both increase sedation. Use Caution/Monitor.
Minor (6)
- ashwagandha
ashwagandha increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- brimonidine
brimonidine increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- eucalyptus
triprolidine and eucalyptus both increase sedation. Minor/Significance Unknown.
- nettle
nettle increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
- sage
triprolidine and sage both increase sedation. Minor/Significance Unknown.
- Siberian ginseng
Siberian ginseng increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
Adverse Effects
Frequency Not Defined
Blurred vision
Sedation
Urinary retention
Constipation
Xerostomia
Warnings
Contraindications
Patients taking sedatives or tranquilizers
Hypersensitivity; note that cross allergenicity may occur between chemically similar antihistamines
Cautions
May cause CNS depression, resulting in impaired physical or mental abilities; caution patients about performing tasks that require mental alertness (eg, driving, operating machinery)
Antihistamines may cause excitation in young children
Discontinue and contact physician if symptoms persist beyond 7 days or are accompanied by fever
Discontinue and contact physician if nervousness, dizziness, or sleeplessness occur
Do not exceed recommended dose
Discontinue therapy and ask doctor if new symptoms occur
Ask a healthcare professional before self-medication if experiencing breathing problems such as emphysema or chronic bronchitis, glaucoma, enlarged prostate (difficulty urinating)
Drug interaction overview
- Sedatives and tranquilizers may increase drowsiness effects
Pregnancy & Lactation
Pregnancy
Limited data exist
Generally, antihistamines are considered low risk during pregnancy; however, exposure near birth of premature infants was associated with increased risk of retrolental fibroplasia
Lactation
Distributed in human breast milk; small, occasional doses are not expected to cause adverse effects in infant
Larger doses may cause irritability or colicky symptoms in infant or decrease milk production in mother; nonsedating antihistamines are preferred during breastfeeding
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
First generation histamine-1 receptor antagonist
Pharmacokinetics
Peak plasma time: 1.5-2 hr
Peak plasma concentration: 5.5-6 ng/mL
Onset: 15-60 min
Duration: 4-6 hr
Half-life: 3.2 hr
Administration
Oral Administration
Do not exceed 4 doses in 24 hr or as directed by physician
Administer only with enclosed dropper or measuring device supplied with specific product
Do not use the dropper or measuring device for other drug products
Storage
Store at controlled room temperature 15-30°C (59-86°F)
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| triprolidine HCl oral - | 0.938 mg/mL drops |  | |
| triprolidine HCl oral - | 0.625 mg/mL drops |  | |
| triprolidine HCl oral - | 0.938 mg/mL drops |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
triprolidine HCl oral
TRIPROLIDINE - ORAL
(trye-PROE-li-deen)
COMMON BRAND NAME(S): Histex, Vanahist PD
USES: Triprolidine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually every 6 hours. Do not take more than 4 doses in a 24-hour period. Follow all directions on the product package. This medication may be taken with food or milk if stomach upset occurs.If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.If you are using the chewable tablets, chew each tablet well and swallow.The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed. Do not take more of this medication than recommended for your age. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.If your symptoms do not improve after 7 days, if they worsen, if you develop fever/chills, or if you think you may have a serious medical problem, get medical help right away.
SIDE EFFECTS: Drowsiness, dizziness, headache, nausea, vomiting, loss of appetite, constipation, stomach upset, blurred vision, decreased coordination, and dry mouth/nose/throat may occur. These effects may decrease as your body adjusts to the medication. If any of these effects last or get worse, contact your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Triprolidine can dry up and thicken mucus in your lungs, making it more difficult to breathe and clear your lungs. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as hallucinations, irritability, nervousness), ringing in the ears, trouble urinating, easy bruising/bleeding, fast/irregular heartbeat, seizures.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking triprolidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), a certain eye problem (glaucoma), heart problems, high blood pressure, liver disease, seizures, stomach problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Liquid products and chewable tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, confusion, and low blood pressure.Children may be more sensitive to the side effects of antihistamines. In young children, this medication may cause agitation/excitement instead of drowsiness.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Do not use with antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.This medication may interfere with certain lab tests (such as allergy skin test), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: large pupils, flushing, fever, hallucinations, weakness, shaking (tremor), muscle twitching, loss of consciousness, seizures. In children, excitement may occur first, and may be followed by loss of coordination, drowsiness, loss of consciousness, seizures.
NOTES: Keep all medical and lab appointments.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
