triprolidine (OTC)

Brand and Other Names:Histex, Vanahist PD, more...Histex PD Drops, M-Hist PD, Vanaclear PD
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral liquid

  • 0.5mg/mL (Histex)
  • 0.625mg/mL (Vanahist PD, M-Hist PD)

Allergic Rhinitis

Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis

Histex: 2.5 mg (5 mL) PO q6hr

Vanahist PD or M-Hist PD: 2.5 mg (4 mL) PO q6hr

Dosage Forms & Strengths

oral liquid

  • 0.5mg/mL (Histex)
  • 0.625mg/mL (Vanahist PD, M-Hist PD)
  • 0.938mg/mL (Histex PD Drops)
  • 0.313mg/mL (Vanaclear PD)

Allergic Rhinitis

Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis

Histex

  • <6 years: As directed by physician
  • 6 to <12 years: 1.25 mg (2.5 mL) PO q6hr prn
  • ≥12 years: 2.5 mg (5 mL) PO q6hr

Vanahist PD or M-Hist PD

  • <6 years: As directed by physician
  • 6 to <12 years: 1.25 mg (2 mL) PO q6hr prn
  • ≥12 years: 2.5 mg (4 mL) PO q6hr

Histex PD Drops

  • 4 month to <2 years: 0.313 mg (0.33 mL) PO q4-6 hr; not to exceed 4 doses (1.33 mL) per 24 hr
  • 2 to <4 years: 0.626 mg (0.67 mL) PO q4-6 hr; not to exceed 4 doses (2.67 mL) per 24 hr
  • 4 to <6 years: 0.938 mg (1 mL) PO q4-6 hr; not to exceed 4 doses (4 mL) per 24 hr

Vanaclear PD

  • 4 month to <2 years: 0.313 mg (1 mL) PO q4-6 hr; not to exceed 4 doses (4 mL) per 24 hr
  • 2 to <4 years: 0.626 mg (2 mL) PO q4-6 hr; not to exceed 4 doses (8 mL) per 24 hr
  • 4 to <6 years: 0.938 mg (3 mL) PO q4-6 hr; not to exceed 4 doses (12 mL) per 24 hr
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Interactions

Interaction Checker

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              Serious - Use Alternative (6)

              • calcium/magnesium/potassium/sodium oxybates

                triprolidine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • eluxadoline

                triprolidine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions.

              • metoclopramide intranasal

                triprolidine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

              • olopatadine intranasal

                triprolidine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

              • pitolisant

                triprolidine decreases effects of pitolisant by Other (see comment). Avoid or Use Alternate Drug. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.

              • sodium oxybate

                triprolidine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              Monitor Closely (186)

              • albuterol

                triprolidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • alfentanil

                triprolidine and alfentanil both increase sedation. Use Caution/Monitor.

              • alprazolam

                triprolidine and alprazolam both increase sedation. Use Caution/Monitor.

              • amifampridine

                triprolidine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.

              • amitriptyline

                triprolidine and amitriptyline both increase sedation. Use Caution/Monitor.

              • amobarbital

                triprolidine and amobarbital both increase sedation. Use Caution/Monitor.

              • amoxapine

                triprolidine and amoxapine both increase sedation. Use Caution/Monitor.

              • arformoterol

                triprolidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • aripiprazole

                triprolidine and aripiprazole both increase sedation. Use Caution/Monitor.

              • armodafinil

                triprolidine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • azelastine

                azelastine and triprolidine both increase sedation. Use Caution/Monitor.

              • belladonna and opium

                triprolidine and belladonna and opium both increase sedation. Use Caution/Monitor.

              • benperidol

                triprolidine and benperidol both increase sedation. Use Caution/Monitor.

              • benzphetamine

                triprolidine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • brexanolone

                brexanolone, triprolidine. Either increases toxicity of the other by sedation. Use Caution/Monitor.

              • brompheniramine

                brompheniramine and triprolidine both increase sedation. Use Caution/Monitor.

              • buprenorphine

                triprolidine and buprenorphine both increase sedation. Use Caution/Monitor.

              • buprenorphine buccal

                triprolidine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

              • butabarbital

                triprolidine and butabarbital both increase sedation. Use Caution/Monitor.

              • butalbital

                triprolidine and butalbital both increase sedation. Use Caution/Monitor.

              • butorphanol

                triprolidine and butorphanol both increase sedation. Use Caution/Monitor.

              • caffeine

                triprolidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • carbinoxamine

                carbinoxamine and triprolidine both increase sedation. Use Caution/Monitor.

              • cenobamate

                cenobamate, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor.

              • chloral hydrate

                triprolidine and chloral hydrate both increase sedation. Use Caution/Monitor.

              • chlordiazepoxide

                triprolidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

              • chlorpheniramine

                chlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.

              • chlorpromazine

                triprolidine and chlorpromazine both increase sedation. Use Caution/Monitor.

              • cinnarizine

                cinnarizine and triprolidine both increase sedation. Use Caution/Monitor.

              • clemastine

                clemastine and triprolidine both increase sedation. Use Caution/Monitor.

              • clobazam

                triprolidine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

              • clomipramine

                triprolidine and clomipramine both increase sedation. Use Caution/Monitor.

              • clonazepam

                triprolidine and clonazepam both increase sedation. Use Caution/Monitor.

              • clorazepate

                triprolidine and clorazepate both increase sedation. Use Caution/Monitor.

              • clozapine

                triprolidine and clozapine both increase sedation. Use Caution/Monitor.

              • codeine

                triprolidine and codeine both increase sedation. Use Caution/Monitor.

              • cyclizine

                cyclizine and triprolidine both increase sedation. Use Caution/Monitor.

              • cyproheptadine

                cyproheptadine and triprolidine both increase sedation. Use Caution/Monitor.

              • daridorexant

                triprolidine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

              • desflurane

                desflurane and triprolidine both increase sedation. Use Caution/Monitor.

              • desipramine

                triprolidine and desipramine both increase sedation. Use Caution/Monitor.

              • dexchlorpheniramine

                dexchlorpheniramine and triprolidine both increase sedation. Use Caution/Monitor.

              • dexfenfluramine

                triprolidine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexmedetomidine

                triprolidine and dexmedetomidine both increase sedation. Use Caution/Monitor.

              • dexmethylphenidate

                triprolidine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextroamphetamine

                triprolidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextromoramide

                triprolidine and dextromoramide both increase sedation. Use Caution/Monitor.

              • diamorphine

                triprolidine and diamorphine both increase sedation. Use Caution/Monitor.

              • diazepam intranasal

                diazepam intranasal, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

              • diethylpropion

                triprolidine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • difelikefalin

                difelikefalin and triprolidine both increase sedation. Use Caution/Monitor.

              • difenoxin hcl

                triprolidine and difenoxin hcl both increase sedation. Use Caution/Monitor.

              • dimenhydrinate

                dimenhydrinate and triprolidine both increase sedation. Use Caution/Monitor.

              • diphenhydramine

                diphenhydramine and triprolidine both increase sedation. Use Caution/Monitor.

              • diphenoxylate hcl

                triprolidine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

              • dipipanone

                triprolidine and dipipanone both increase sedation. Use Caution/Monitor.

              • dobutamine

                triprolidine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • donepezil transdermal

                donepezil transdermal, triprolidine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

              • dopamine

                triprolidine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dopexamine

                triprolidine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dosulepin

                triprolidine and dosulepin both increase sedation. Use Caution/Monitor.

              • doxepin

                triprolidine and doxepin both increase sedation. Use Caution/Monitor.

              • doxylamine

                triprolidine and doxylamine both increase sedation. Use Caution/Monitor.

              • droperidol

                triprolidine and droperidol both increase sedation. Use Caution/Monitor.

              • ephedrine

                triprolidine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine

                triprolidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine racemic

                triprolidine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • esketamine intranasal

                esketamine intranasal, triprolidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

              • estazolam

                triprolidine and estazolam both increase sedation. Use Caution/Monitor.

              • ethanol

                triprolidine and ethanol both increase sedation. Use Caution/Monitor.

              • etomidate

                etomidate and triprolidine both increase sedation. Use Caution/Monitor.

              • fenfluramine

                triprolidine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • fentanyl

                fentanyl, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

              • fentanyl intranasal

                fentanyl intranasal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

              • fentanyl transdermal

                fentanyl transdermal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

              • fentanyl transmucosal

                fentanyl transmucosal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

              • flibanserin

                triprolidine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

              • fluphenazine

                triprolidine and fluphenazine both increase sedation. Use Caution/Monitor.

              • flurazepam

                triprolidine and flurazepam both increase sedation. Use Caution/Monitor.

              • formoterol

                triprolidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • gabapentin

                gabapentin, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • gabapentin enacarbil

                gabapentin enacarbil, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • ganaxolone

                triprolidine and ganaxolone both increase sedation. Use Caution/Monitor.

              • glycopyrronium tosylate topical

                glycopyrronium tosylate topical, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

              • gotu kola

                gotu kola increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • haloperidol

                triprolidine and haloperidol both increase sedation. Use Caution/Monitor.

              • hawthorn

                hawthorn increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • hops

                hops increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • hydromorphone

                triprolidine and hydromorphone both increase sedation. Use Caution/Monitor.

              • hydroxyzine

                hydroxyzine and triprolidine both increase sedation. Use Caution/Monitor.

              • iloperidone

                triprolidine and iloperidone both increase sedation. Use Caution/Monitor.

              • imipramine

                triprolidine and imipramine both increase sedation. Use Caution/Monitor.

              • isoproterenol

                triprolidine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • kava

                kava increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • ketamine

                ketamine and triprolidine both increase sedation. Use Caution/Monitor.

              • ketotifen, ophthalmic

                triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

              • lasmiditan

                lasmiditan, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

              • lemborexant

                lemborexant, triprolidine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

              • levalbuterol

                triprolidine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • levorphanol

                triprolidine and levorphanol both increase sedation. Use Caution/Monitor.

              • lisdexamfetamine

                triprolidine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lofepramine

                triprolidine and lofepramine both increase sedation. Use Caution/Monitor.

              • lofexidine

                triprolidine and lofexidine both increase sedation. Use Caution/Monitor.

              • loprazolam

                triprolidine and loprazolam both increase sedation. Use Caution/Monitor.

              • lorazepam

                triprolidine and lorazepam both increase sedation. Use Caution/Monitor.

              • lormetazepam

                triprolidine and lormetazepam both increase sedation. Use Caution/Monitor.

              • loxapine

                triprolidine and loxapine both increase sedation. Use Caution/Monitor.

              • loxapine inhaled

                triprolidine and loxapine inhaled both increase sedation. Use Caution/Monitor.

              • lurasidone

                lurasidone, triprolidine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

              • maprotiline

                triprolidine and maprotiline both increase sedation. Use Caution/Monitor.

              • marijuana

                triprolidine and marijuana both increase sedation. Use Caution/Monitor.

              • melatonin

                triprolidine and melatonin both increase sedation. Use Caution/Monitor.

              • meperidine

                triprolidine and meperidine both increase sedation. Use Caution/Monitor.

              • meprobamate

                triprolidine and meprobamate both increase sedation. Use Caution/Monitor.

              • metaproterenol

                triprolidine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • methadone

                triprolidine and methadone both increase sedation. Use Caution/Monitor.

              • methamphetamine

                triprolidine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • methylenedioxymethamphetamine

                triprolidine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • midazolam

                triprolidine and midazolam both increase sedation. Use Caution/Monitor.

              • midazolam intranasal

                midazolam intranasal, triprolidine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

              • midodrine

                triprolidine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • mirtazapine

                triprolidine and mirtazapine both increase sedation. Use Caution/Monitor.

              • modafinil

                triprolidine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • morphine

                triprolidine and morphine both increase sedation. Use Caution/Monitor.

              • motherwort

                triprolidine and motherwort both increase sedation. Use Caution/Monitor.

              • moxonidine

                triprolidine and moxonidine both increase sedation. Use Caution/Monitor.

              • nabilone

                triprolidine and nabilone both increase sedation. Use Caution/Monitor.

              • nalbuphine

                triprolidine and nalbuphine both increase sedation. Use Caution/Monitor.

              • norepinephrine

                triprolidine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nortriptyline

                triprolidine and nortriptyline both increase sedation. Use Caution/Monitor.

              • olanzapine

                triprolidine and olanzapine both increase sedation. Use Caution/Monitor.

              • opium tincture

                triprolidine and opium tincture both increase sedation. Use Caution/Monitor.

              • oxazepam

                triprolidine and oxazepam both increase sedation. Use Caution/Monitor.

              • oxycodone

                triprolidine and oxycodone both increase sedation. Use Caution/Monitor.

              • oxymorphone

                triprolidine and oxymorphone both increase sedation. Use Caution/Monitor.

              • paliperidone

                triprolidine and paliperidone both increase sedation. Use Caution/Monitor.

              • papaveretum

                triprolidine and papaveretum both increase sedation. Use Caution/Monitor.

              • papaverine

                triprolidine and papaverine both increase sedation. Use Caution/Monitor.

              • passion flower

                passion flower increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • pentazocine

                triprolidine and pentazocine both increase sedation. Use Caution/Monitor.

              • pentobarbital

                triprolidine and pentobarbital both increase sedation. Use Caution/Monitor.

              • perphenazine

                triprolidine and perphenazine both increase sedation. Use Caution/Monitor.

              • phendimetrazine

                triprolidine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenobarbital

                triprolidine and phenobarbital both increase sedation. Use Caution/Monitor.

              • phentermine

                triprolidine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine

                triprolidine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine PO

                triprolidine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • pholcodine

                triprolidine and pholcodine both increase sedation. Use Caution/Monitor.

              • pimozide

                triprolidine and pimozide both increase sedation. Use Caution/Monitor.

              • pirbuterol

                triprolidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pregabalin

                pregabalin, triprolidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • primidone

                triprolidine and primidone both increase sedation. Use Caution/Monitor.

              • prochlorperazine

                triprolidine and prochlorperazine both increase sedation. Use Caution/Monitor.

              • promethazine

                promethazine and triprolidine both increase sedation. Use Caution/Monitor.

              • propofol

                propofol and triprolidine both increase sedation. Use Caution/Monitor.

              • propylhexedrine

                triprolidine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • protriptyline

                triprolidine and protriptyline both increase sedation. Use Caution/Monitor.

              • quazepam

                triprolidine and quazepam both increase sedation. Use Caution/Monitor.

              • quetiapine

                triprolidine and quetiapine both increase sedation. Use Caution/Monitor.

              • ramelteon

                triprolidine and ramelteon both increase sedation. Use Caution/Monitor.

              • risperidone

                triprolidine and risperidone both increase sedation. Use Caution/Monitor.

              • salmeterol

                triprolidine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • scullcap

                triprolidine and scullcap both increase sedation. Use Caution/Monitor.

              • secobarbital

                triprolidine and secobarbital both increase sedation. Use Caution/Monitor.

              • sevoflurane

                sevoflurane and triprolidine both increase sedation. Use Caution/Monitor.

              • shepherd's purse

                triprolidine and shepherd's purse both increase sedation. Use Caution/Monitor.

              • stiripentol

                stiripentol, triprolidine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

              • sufentanil

                triprolidine and sufentanil both increase sedation. Use Caution/Monitor.

              • tapentadol

                triprolidine and tapentadol both increase sedation. Use Caution/Monitor.

              • temazepam

                triprolidine and temazepam both increase sedation. Use Caution/Monitor.

              • terbutaline

                triprolidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • thioridazine

                triprolidine and thioridazine both increase sedation. Use Caution/Monitor.

              • thiothixene

                triprolidine and thiothixene both increase sedation. Use Caution/Monitor.

              • topiramate

                triprolidine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

              • tramadol

                triprolidine and tramadol both increase sedation. Use Caution/Monitor.

              • trazodone

                triprolidine and trazodone both increase sedation. Use Caution/Monitor.

              • triazolam

                triprolidine and triazolam both increase sedation. Use Caution/Monitor.

              • triclofos

                triprolidine and triclofos both increase sedation. Use Caution/Monitor.

              • trifluoperazine

                triprolidine and trifluoperazine both increase sedation. Use Caution/Monitor.

              • trimipramine

                triprolidine and trimipramine both increase sedation. Use Caution/Monitor.

              • valerian

                valerian increases effects of triprolidine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

              • xylometazoline

                triprolidine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • yohimbine

                triprolidine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ziconotide

                triprolidine and ziconotide both increase sedation. Use Caution/Monitor.

              • ziprasidone

                triprolidine and ziprasidone both increase sedation. Use Caution/Monitor.

              • zotepine

                triprolidine and zotepine both increase sedation. Use Caution/Monitor.

              Minor (6)

              • ashwagandha

                ashwagandha increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

              • brimonidine

                brimonidine increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

              • eucalyptus

                triprolidine and eucalyptus both increase sedation. Minor/Significance Unknown.

              • nettle

                nettle increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

              • sage

                triprolidine and sage both increase sedation. Minor/Significance Unknown.

              • Siberian ginseng

                Siberian ginseng increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

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              Adverse Effects

              Frequency Not Defined

              Blurred vision

              Sedation

              Urinary retention

              Constipation

              Xerostomia

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              Warnings

              Contraindications

              Patients taking sedatives or tranquilizers

              Hypersensitivity; note that cross allergenicity may occur between chemically similar antihistamines

              Cautions

              May cause CNS depression, resulting in impaired physical or mental abilities; caution patients about performing tasks that require mental alertness (eg, driving, operating machinery)

              Antihistamines may cause excitation in young children

              Discontinue and contact physician if symptoms persist beyond 7 days or are accompanied by fever

              Discontinue and contact physician if nervousness, dizziness, or sleeplessness occur

              Do not exceed recommended dose

              Discontinue therapy and ask doctor if new symptoms occur

              Ask a healthcare professional before self-medication if experiencing breathing problems such as emphysema or chronic bronchitis, glaucoma, enlarged prostate (difficulty urinating)

              Drug interaction overview

              • Sedatives and tranquilizers may increase drowsiness effects
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              Pregnancy & Lactation

              Pregnancy

              Limited data exist

              Generally, antihistamines are considered low risk during pregnancy; however, exposure near birth of premature infants was associated with increased risk of retrolental fibroplasia

              Lactation

              Distributed in human breast milk; small, occasional doses are not expected to cause adverse effects in infant

              Larger doses may cause irritability or colicky symptoms in infant or decrease milk production in mother; nonsedating antihistamines are preferred during breastfeeding

              Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              First generation histamine-1 receptor antagonist

              Pharmacokinetics

              Peak plasma time: 1.5-2 hr

              Peak plasma concentration: 5.5-6 ng/mL

              Onset: 15-60 min

              Duration: 4-6 hr

              Half-life: 3.2 hr

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              Administration

              Oral Administration

              Do not exceed 4 doses in 24 hr or as directed by physician

              Administer only with enclosed dropper or measuring device supplied with specific product

              Do not use the dropper or measuring device for other drug products

              Storage

              Store at controlled room temperature 15-30°C (59-86°F)

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              triprolidine HCl oral
              -
              0.938 mg/mL drops

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Patient Education
              triprolidine HCl oral

              TRIPROLIDINE - ORAL

              (trye-PROE-li-deen)

              COMMON BRAND NAME(S): Histex, Vanahist PD

              USES: Triprolidine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

              HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually every 6 hours. Do not take more than 4 doses in a 24-hour period. Follow all directions on the product package. This medication may be taken with food or milk if stomach upset occurs.If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.If you are using the chewable tablets, chew each tablet well and swallow.The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed. Do not take more of this medication than recommended for your age. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.If your symptoms do not improve after 7 days, if they worsen, if you develop fever/chills, or if you think you may have a serious medical problem, get medical help right away.

              SIDE EFFECTS: Drowsiness, dizziness, headache, nausea, vomiting, loss of appetite, constipation, stomach upset, blurred vision, decreased coordination, and dry mouth/nose/throat may occur. These effects may decrease as your body adjusts to the medication. If any of these effects last or get worse, contact your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Triprolidine can dry up and thicken mucus in your lungs, making it more difficult to breathe and clear your lungs. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as hallucinations, irritability, nervousness), ringing in the ears, trouble urinating, easy bruising/bleeding, fast/irregular heartbeat, seizures.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking triprolidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), a certain eye problem (glaucoma), heart problems, high blood pressure, liver disease, seizures, stomach problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Liquid products and chewable tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, confusion, and low blood pressure.Children may be more sensitive to the side effects of antihistamines. In young children, this medication may cause agitation/excitement instead of drowsiness.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Do not use with antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.This medication may interfere with certain laboratory tests (including allergy skin test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: large pupils, flushing, fever, hallucinations, weakness, shaking (tremor), muscle twitching, loss of consciousness, seizures. In children, excitement may occur first, and may be followed by loss of coordination, drowsiness, loss of consciousness, seizures.

              NOTES: Keep all regular medical and laboratory appointments.

              MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

              Information last revised January 2022. Copyright(c) 2022 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.