Dosing & Uses
Dosage Forms & Strengths
powder for injection
- 250 units
Tetanus
Prophylaxis: 250 Units IM (single dose)
Active tetanus: 3000-6000 Units IM
Clean minor wound
- # doses unknown or 0-2 doses; toxoid only
- >3 doses; toxoid if >10 years ago
All other wounds
- # doses unknown or 0-1 doses; toxoid plus IG
- 2 doses; toxoid, but no IG if wound <24 hours old
- >3 doses; toxoid if >5 years ago, and no IG
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
Frequency Not Defined
Urticaria
Injection site pain
N/V
Fever
Lethargy
Chest tightness
Anaphylaxis
Angioneurotic edema
Nephrotic syndrome (rare)
Warnings
Contraindications
Hypersensitivity to gamma globulin, IgA, thimerosal
Cautions
Thrombocytopenia or coagulation disorders may contraindicate IM injection
Made from human plasma, small risk of viral transmission through administration
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk, no adverse effects reported
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Mechanism of Action
Human immune globulins from donors
Pharmacokinetics
Half-life: 23 days
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
