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    Drugs & Diseases

    tetanus immune globulin (TIG) (Rx)

    Brand and Other Names:Hyper Tet, HyperTET S/D, more...TIG
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    Dosing & Uses

    AdultPediatric

    Dosage Forms & Strengths

    powder for injection

    • 250 units

    Tetanus

    Prophylaxis: 250 Units IM (single dose)

    Active tetanus: 3000-6000 Units IM

    Clean minor wound

    • # doses unknown or 0-2 doses; toxoid only
    • >3 doses; toxoid if >10 years ago

    All other wounds

    • # doses unknown or 0-1 doses; toxoid plus IG
    • 2 doses; toxoid, but no IG if wound <24 hours old
    • >3 doses; toxoid if >5 years ago, and no IG

    Dosage Forms & Strengths

    powder for injection

    • 250 units

    Tetanus Prophylaxis

    <7 years old: 4 Unit/kg or 250 Units IM  

    >7 years old: 250 Units IM (single dose)

    Tetanus Treatment

    3000-6000 Units IM

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    Interactions

    Interaction Checker

    and tetanus immune globulin (TIG)

    No Results

       activity indicator 
      No Interactions Found
      Interactions Found

      Contraindicated

        Serious - Use Alternative

          Significant - Monitor Closely

            Minor

              All Interactions Sort By:
               activity indicator 

              Contraindicated (0)

                Serious - Use Alternative (0)

                  Monitor Closely (8)

                  • adenovirus types 4 and 7 live, oral

                    tetanus immune globulin (TIG) decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • BCG vaccine live

                    tetanus immune globulin (TIG) decreases effects of BCG vaccine live by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • measles (rubeola) vaccine

                    tetanus immune globulin (TIG) decreases effects of measles (rubeola) vaccine by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • measles mumps and rubella vaccine, live

                    tetanus immune globulin (TIG) decreases effects of measles mumps and rubella vaccine, live by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • measles, mumps, rubella and varicella vaccine, live

                    tetanus immune globulin (TIG) decreases effects of measles, mumps, rubella and varicella vaccine, live by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • rubella vaccine

                    tetanus immune globulin (TIG) decreases effects of rubella vaccine by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • smallpox (vaccinia) vaccine, live

                    tetanus immune globulin (TIG) decreases effects of smallpox (vaccinia) vaccine, live by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  • varicella virus vaccine live

                    tetanus immune globulin (TIG) decreases effects of varicella virus vaccine live by pharmacodynamic antagonism. Use Caution/Monitor. Separate by 3 months.

                  Minor (1)

                  • protein a column

                    protein a column decreases levels of tetanus immune globulin (TIG) by Other (see comment). Minor/Significance Unknown. Comment: Since Prosorba binds IgG, it could theoretically interfere with the levels and/or effects of pharmacologic immune globulins.

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                  Adverse Effects

                  Frequency Not Defined

                  Urticaria

                  Injection site pain

                  N/V

                  Fever

                  Lethargy

                  Chest tightness

                  Anaphylaxis

                  Angioneurotic edema

                  Nephrotic syndrome (rare)

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                  Warnings

                  Contraindications

                  Hypersensitivity to gamma globulin, IgA, thimerosal

                  Cautions

                  Thrombocytopenia or coagulation disorders may contraindicate IM injection

                  Made from human plasma, small risk of viral transmission through administration

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: not known if excreted in breast milk, no adverse effects reported

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Human immune globulins from donors

                  Pharmacokinetics

                  Half-life: 23 days

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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Create Your List of Plans

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  View explanations for tiers and restrictions
                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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