indapamide (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablets

  • 1.25mg
  • 2.5mg

Edema

2.5 mg PO qDay initially; may increase to 5 mg qDay

Hypertension

1.25 mg PO qAM initially; may increase at 4-week intervals up to 5 mg qAM

Overdose Management

May use normal saline for volume replacement

May use dopamine or norepinephrine to treat hypotension

If dysrhythmia due to decreased K+ or Mg+ suspected replace aggressively

Discontinue treatment if no symptoms after 6hr

Safety & efficacy not established

Edema

2.5 mg PO qDay initially; may increase to 5 mg qDay

Hypertension

1.25 mg PO qAM initially; may increase at 4-week intervals up to 5 mg qAM

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Interactions

Interaction Checker

and indapamide

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Hypotension

            Palpation

            Flushing

            Dizziness

            Lightheadedness

            Vertigo

            Headache

            Weakness

            Restlessness

            Drowsiness

            Fatigue

            Lethargy

            Malaise

            Anorexia

            Nausea/vomiting

            Nocturia

            Polyuria

            Blurred vision

            Rhinnorhea

            Electrolyte abnormalities

            Pruritus

            Rash

            <1%

            Cutaneous vasculitis

            Glycosuria

            Pancreatitis

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            Warnings

            Contraindications

            Hypersensitivity to indapamide or sulfonamides

            Anuria

            Cautions

            Hypotension, DM, fluid or electrolyte imbalance, hyperuricemia or gout, SLE, liver disease, renal disease

            Avoid concurrent use with lithium

            More effective in impaired renal function than thiazides

            No effect on lipids/cholesterol

            Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses in elderly females

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: not known if excreted into breast milk, avoid

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Similar to thiazide diuretics, enhances Na, Cl and water excretion by interfering with transport of Na+ ion across renal tubular epithelium at proximal segment of distal tubule

            Pharmacokinetics

            Half-Life: 14-25 hr

            Onset: 1-3 hr

            Duration: 8-12 hr

            Peak Plasma Time: 2 hr

            Bioavailability: 93%

            Protein Bound: 71-79%

            Vd: 24-25 L

            Metabolism: Liver

            Metabolites: 19 metabolites, not identified, activity unknown

            Excretion: Urine (70% with 7% unchanged), feces (23%)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.