Indication-specific dosing for Indian Ginseng, Withania, Withania Somnifera (ashwagandha), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Ashwagandha
Suggested Dosing
Suggested Uses
Interactions
Warnings
Pregnancy
Pharmacology

Suggested Dosing

No Typical Dosage

Capsule: 1-6 g whole herb PO qDay

Tea form: 3 cups qD (1-6g whole herb)

Tincture: 2-4 mL PO TID

Suggested Uses

Adaptogen: adapt to internal/external stressors, fight fatigue, increase stamina

Efficacy

Insufficient information

Interaction Checker

Enter a drug name and Ashwagandha

No Results

No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By:

Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (0)

Minor (26)

amobarbital
ashwagandha increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
azelastine
ashwagandha increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
brompheniramine
ashwagandha increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
butabarbital
ashwagandha increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
butalbital
ashwagandha increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
carbinoxamine
ashwagandha increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
chloral hydrate
ashwagandha increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
chlorpheniramine
ashwagandha increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cinnarizine
ashwagandha increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
clemastine
ashwagandha increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cyclizine
ashwagandha increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cyproheptadine
ashwagandha increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dexchlorpheniramine
ashwagandha increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dexmedetomidine
ashwagandha increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dextroamphetamine
ashwagandha increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown.
dimenhydrinate
ashwagandha increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
diphenhydramine
ashwagandha increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
doxylamine
ashwagandha increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
hydroxyzine
ashwagandha increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
pentobarbital
ashwagandha increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
phenobarbital
ashwagandha increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
primidone
ashwagandha increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
promethazine
ashwagandha increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
secobarbital
ashwagandha increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
triclofos
ashwagandha increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
triprolidine
ashwagandha increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

amobarbital
Minor (1)ashwagandha increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
azelastine
Minor (1)ashwagandha increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
brompheniramine
Minor (1)ashwagandha increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
butabarbital
Minor (1)ashwagandha increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
butalbital
Minor (1)ashwagandha increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
carbinoxamine
Minor (1)ashwagandha increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
chloral hydrate
Minor (1)ashwagandha increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
chlorpheniramine
Minor (1)ashwagandha increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cinnarizine
Minor (1)ashwagandha increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
clemastine
Minor (1)ashwagandha increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cyclizine
Minor (1)ashwagandha increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
cyproheptadine
Minor (1)ashwagandha increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dexchlorpheniramine
Minor (1)ashwagandha increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dexmedetomidine
Minor (1)ashwagandha increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
dextroamphetamine
Minor (1)ashwagandha increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown.
dimenhydrinate
Minor (1)ashwagandha increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
diphenhydramine
Minor (1)ashwagandha increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
doxylamine
Minor (1)ashwagandha increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
hydroxyzine
Minor (1)ashwagandha increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
pentobarbital
Minor (1)ashwagandha increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
phenobarbital
Minor (1)ashwagandha increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
primidone
Minor (1)ashwagandha increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
promethazine
Minor (1)ashwagandha increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
secobarbital
Minor (1)ashwagandha increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
triclofos
Minor (1)ashwagandha increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
triprolidine
Minor (1)ashwagandha increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

Contraindications

Hypertension

Pregnancy

Pregnancy & Lactation

Pregnancy Category: X

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Withanolides, ipuranol, withaniol anti-inflammatory, decrease BP, resp. stimulation, smooth muscle relaxation

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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