nadofaragene firadenovec (Pending FDA Approval)

Brand and Other Names:Instilidrin
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Dosing & Uses

Bladder Cancer

Pending FDA approval for high-grade, Bacillus Calmette-Guérin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC)

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Pharmacology

Mechanism of Action

Replication-deficient recombinant adenovirus encoding human interferon alpha-2b with potential antineoplastic activity

Upon intravesical administration, nadofaragene firadenovec infects nearby tumor cells and expresses INF alpha-2b intracellularly which activates the transcription and translation of genes whose products mediate antiviral, antiproliferative, antitumor, and immune-modulating effects

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.