Vinpocetine (Herb/Suppl)

Brand and Other Names:Intelectol
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Suggested Dosing

Cognitive impairment due to vascular disease

5-10 mg PO TID

Take with food

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Suggested Uses

Increases cerebral blood flow and metabolism, anticonvulsation, cognition enhancement, neuroprotection, antioxidation, cerebral vasodilation

Efficacy

Some clinical studies show prophylactic effects in ischemic stroke & cognitive improvement

Sold as a legal pharmaceutical product in Japan, Europe, & Mexico

Not beneficial in Alzheimer's disease

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Interactions

Interaction Checker

and Vinpocetine

No Results

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (15)

                  • alprazolam

                    alprazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • chlordiazepoxide

                    chlordiazepoxide increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • clonazepam

                    clonazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • clorazepate

                    clorazepate increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • diazepam

                    diazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • estazolam

                    estazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • flurazepam

                    flurazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • loprazolam

                    loprazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • lorazepam

                    lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • lormetazepam

                    lormetazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • midazolam

                    midazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • oxazepam

                    oxazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • quazepam

                    quazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • temazepam

                    temazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

                  • triazolam

                    triazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

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                  Adverse Effects

                  Frequency Not Defined

                  Nausea

                  Dizziness

                  Insomnia

                  Drowsiness

                  Dry mouth

                  Transient hypotension

                  Transient tachycardia

                  Pressure-type headache

                  Facial flushing

                  Prolonged use: slight reductions in both systolic & diastolic blood pressure & blood glucose

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                  Warnings

                  Contraindications

                  Hypersensitivity to vinpocetine or other vinca alkaloids

                  Pts in incomplete homeostasis after cerebral haemorrhage

                  Pregnancy, lactation

                  <18 years old

                  Cautions

                  Hemophilia, heart problems or low blood pressure

                  Monitor INR in patients on warfarin

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid

                  Lactation: avoid

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Peak Plasma Time: 1-1.5 hr

                  Half-Life, elimination: 1-2 hr

                  Absorption: 60% with food, 7% without

                  Metabolism: extensively to inactive apovincaminic acid in liver

                  Excretion: urine

                  Mechanism of Action

                  Shown to inhibit cGMP phosphodiesterase that has may result in increased cerebral blood flow

                  Reported to have calcium-channel blocker, voltage-gated sodium channel blocker, & acetylcholine release activities

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.