iodine (OTC)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

RDA

150 mcg/day

Pregnancy: 220 mcg/day

Lactation: 290 mcg/day

RDA

1-8 years: 90 mcg/day

8-13 years: 120 mcg/day

13-18 years: 150 mcg/day

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Interactions

Interaction Checker

and iodine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • baloxavir marboxil

                iodine will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

              Monitor Closely (2)

              • omadacycline

                iodine will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              • sarecycline

                iodine will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              Minor (12)

              • amiloride

                iodine, amiloride. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • drospirenone

                iodine, drospirenone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • iodine (radioactive)

                iodine, iodine (radioactive). Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.

              • iodoquinol

                iodoquinol increases effects of iodine by pharmacodynamic synergism. Minor/Significance Unknown.

              • lithium

                iodine, lithium. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.

              • methimazole

                iodine, methimazole. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.

              • potassium acid phosphate

                iodine increases levels of potassium acid phosphate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • potassium chloride

                iodine increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • potassium citrate

                iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • propylthiouracil

                iodine, propylthiouracil. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.

              • spironolactone

                iodine, spironolactone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • triamterene

                iodine, triamterene. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

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              Adverse Effects

              Frequency Not Defined

              Metallic taste

              Fever

              Arthralgia

              Diarrhea

              Angioedema

              Urticaria

              Eosinophilia

              Headache

              Pulmonary edema

              Thyroid suppression

              Acne (high dose)

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              Warnings

              Contraindications

              Hypersensitivity to drug or components

              Cautions

              Excessive iodine may cause hypothyroidism by feedback inhibition of thyroid hormone production & conversion of triiodothyronine (T3) to less active thyroxine (T4)

              Use caution in patients with renal impairment

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              Pregnancy & Lactation

              Pregnancy Category: Not studied

              Lactation: Enters breast milk; use caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Required for thyroid hormone synthesis; component of thyroid hormones (T3 & T4)

              Pharmacokinetics

              Bioavailability: 90%

              Excretion: 90% (urine)

              Distribution: Thyroid

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              Images

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              Patient Handout

              A Patient Handout is not currently available for this monograph.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.