(iodine) dosing, indications, interactions, adverse effects, and more

Sections

Sections iodine
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout

Dosing & Uses

AdultPediatric

RDA

150 mcg/day

Pregnancy: 220 mcg/day

Lactation: 290 mcg/day

RDA

1-8 years: 90 mcg/day

8-13 years: 120 mcg/day

13-18 years: 150 mcg/day

Interaction Checker

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Contraindicated

Serious - Use Alternative

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Contraindicated (0)

Serious - Use Alternative (1)

baloxavir marboxil
iodine will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

Monitor Closely (2)

omadacycline
iodine will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.
sarecycline
iodine will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

Minor (12)

amiloride
iodine, amiloride. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
drospirenone
iodine, drospirenone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
iodine (radioactive)
iodine, iodine (radioactive). Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
iodoquinol
iodoquinol increases effects of iodine by pharmacodynamic synergism. Minor/Significance Unknown.
lithium
iodine, lithium. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
methimazole
iodine, methimazole. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
potassium acid phosphate
iodine increases levels of potassium acid phosphate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
potassium chloride
iodine increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
potassium citrate
iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
propylthiouracil
iodine, propylthiouracil. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
spironolactone
iodine, spironolactone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
triamterene
iodine, triamterene. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

amiloride
Minor (1)iodine, amiloride. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
baloxavir marboxil
Serious - Use Alternative (1)iodine will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.
drospirenone
Minor (1)iodine, drospirenone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
iodine (radioactive)
Minor (1)iodine, iodine (radioactive). Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
iodoquinol
Minor (1)iodoquinol increases effects of iodine by pharmacodynamic synergism. Minor/Significance Unknown.
lithium
Minor (1)iodine, lithium. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
methimazole
Minor (1)iodine, methimazole. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
omadacycline
Monitor Closely (1)iodine will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.
potassium acid phosphate
Minor (1)iodine increases levels of potassium acid phosphate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
potassium chloride
Minor (1)iodine increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
potassium citrate
Minor (1)iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
propylthiouracil
Minor (1)iodine, propylthiouracil. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypothyroid effects.
sarecycline
Monitor Closely (1)iodine will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.
spironolactone
Minor (1)iodine, spironolactone. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.
triamterene
Minor (1)iodine, triamterene. Mechanism: decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

Frequency Not Defined

Metallic taste

Fever

Arthralgia

Diarrhea

Angioedema

Urticaria

Eosinophilia

Headache

Pulmonary edema

Thyroid suppression

Acne (high dose)

Contraindications

Hypersensitivity to drug or components

Cautions

Excessive iodine may cause hypothyroidism by feedback inhibition of thyroid hormone production & conversion of triiodothyronine (T3) to less active thyroxine (T4)

Use caution in patients with renal impairment

Pregnancy & Lactation

Pregnancy Category: Not studied

Lactation: Enters breast milk; use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Required for thyroid hormone synthesis; component of thyroid hormones (T3 & T4)

Pharmacokinetics

Bioavailability: 90%

Excretion: 90% (urine)

Distribution: Thyroid

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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