Phytoestrogens (Herb/Suppl)

Brand and Other Names:isoflavones, daidzein, more...genistein, ipriflavone, ostivone, soy isoflavones
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Suggested Dosing

Isoflavones

40 mg PO qD

Menopausal symptoms: 34-120 mg/d

Hypertension: 18 mg PO BID

Lung cancer prevention: 8.3 -83.2 mcg/d

Ipriflavone

200 mg PO TID

CrCl 40-80 mL/min

200 mg PO BID

CrCl <40 mL/min

200 mg PO qD

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Suggested Uses

Menopausal vasomotor symptoms, osteoporosis

Decrease risk of breast cancer, CVD

Efficacy

Studies show reasonable efficacy for breast cancer, diabetes, osteoporosis prevention/treatment, hot flashes, CVD risk

Mixed results for cancer prevention

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Interactions

Interaction Checker

and Phytoestrogens

No Results

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (70)

                • aceclofenac

                  aceclofenac and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • American ginseng

                  American ginseng and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • dalteparin

                  dalteparin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  feverfew and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • flaxseed

                  phytoestrogens, flaxseed. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both contain phytoestrogens.

                • flurbiprofen

                  flurbiprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  garlic and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ginger

                  ginger and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  ginkgo biloba and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  horse chestnut seed and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  phytoestrogens increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • nettle

                  phytoestrogens increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  panax ginseng and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  pau d'arco and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • piroxicam

                  piroxicam and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • red clover

                  phytoestrogens, red clover. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both contain phytoestrogens.

                • reishi

                  phytoestrogens and reishi both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • Siberian ginseng

                  phytoestrogens and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  phytoestrogens increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • warfarin

                  warfarin and phytoestrogens both increase anticoagulation. Modify Therapy/Monitor Closely.

                Minor (22)

                • anamu

                  anamu and phytoestrogens both increase anticoagulation. Minor/Significance Unknown.

                • bazedoxifene/conjugated estrogens

                  phytoestrogens decreases effects of bazedoxifene/conjugated estrogens by pharmacodynamic antagonism. Minor/Significance Unknown.

                • cimetidine

                  cimetidine decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • conjugated estrogens

                  phytoestrogens decreases effects of conjugated estrogens by pharmacodynamic antagonism. Minor/Significance Unknown.

                • conjugated estrogens, vaginal

                  phytoestrogens decreases effects of conjugated estrogens, vaginal by pharmacodynamic antagonism. Minor/Significance Unknown.

                • danshen

                  danshen and phytoestrogens both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and phytoestrogens both increase anticoagulation. Minor/Significance Unknown.

                • dexlansoprazole

                  dexlansoprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • esomeprazole

                  esomeprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • estradiol

                  phytoestrogens decreases effects of estradiol by pharmacodynamic antagonism. Minor/Significance Unknown.

                • estrogens conjugated synthetic

                  phytoestrogens decreases effects of estrogens conjugated synthetic by pharmacodynamic antagonism. Minor/Significance Unknown.

                • estrogens esterified

                  phytoestrogens decreases effects of estrogens esterified by pharmacodynamic antagonism. Minor/Significance Unknown.

                • estropipate

                  phytoestrogens decreases effects of estropipate by pharmacodynamic antagonism. Minor/Significance Unknown.

                • famotidine

                  famotidine decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ibuprofen/famotidine

                  ibuprofen/famotidine decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • lansoprazole

                  lansoprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • mestranol

                  phytoestrogens decreases effects of mestranol by pharmacodynamic antagonism. Minor/Significance Unknown.

                • nizatidine

                  nizatidine decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • omeprazole

                  omeprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • pantoprazole

                  pantoprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • rabeprazole

                  rabeprazole decreases levels of phytoestrogens by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • theophylline

                  phytoestrogens increases levels of theophylline by decreasing metabolism. Minor/Significance Unknown.

                  phytoestrogens increases levels of theophylline by decreasing elimination. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Allergic reaction

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                Warnings

                Contraindications

                Pregnancy

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                Pregnancy & Lactation

                Pregnancy Category: avoid use

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Partial estrogen receptor agonists; anti-estrogenic effects in premenopausal women, but weak estrogenic effects in postmenopausal women

                May stimulate osteoblastic activity

                Incr sex hormone binding globulin (SHBG) levels; antioxidant activity

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.