Dosing & Uses
Inner Ear Tinnitus
Pending FDA approval for treatment of acute inner ear tinnitus following acute acoustic trauma or otitis media
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Pharmacology
Mechanism of Action
N-Methyl-D-aspartate (NMDA) receptor antagonist that suppresses the excitation of the auditory nerve that is perceived as tinnitus
Inner ear insults may trigger increased levels of extracellular glutamate leading to excessive activation of cochlear NMDA receptors, which result in sensory cell damage
Damage to sensory cells is the proposed mechanism responsible for abnormal spontaneous firing of auditory nerves, resulting in perceived tinnitus
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
