sulfacetamide topical (Rx)

Brand and Other Names:Klaron, Ovace Plus, more...Ovace Plus Shampoo, Ovace Plus Wash, Ovace Wash
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

lotion

  • 10% (Klaron)

cream

  • 10% (Ovace Plus)

shampoo

  • 10% (Ovace Plus Shampoo)

wash, oil in water emulsion

  • 10% (Ovace Plus Wash)

wash

  • 10% (Ovace Wash)

Acne Vulgaris

Klaron: Apply thin film topically to affected areas BID

Seborrheic Dermatitis

Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides

Ovace Plus Cream: Apply to affeted areas BID x8-10 days

Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days

For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence

Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week

Administration

Avoid contact with eyes or mucous membranes

Dosage Forms & Strengths

lotion

  • 10% (Klaron)

cream

  • 10% (Ovace Plus)

shampoo

  • 10% (Ovace Plus Shampoo)

wash, oil in water emulsion

  • 10% (Ovace Plus Wash)

wash

  • 10% (Ovace Wash)

Acne Vulgaris

<12 years: Safety and efficacy not established

Klaron ≥12 years: Apply thin film topically to affected areas BID

Seborrheic Dermatitis

Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides

<12 years: Safety and efficacy not established

≥12 years

  • Ovace Plus Cream: Apply to affeted areas BID x8-10 days
  • Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
  • For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
  • Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week

Administration

Avoid contact with eyes or mucous membranes

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Interactions

Interaction Checker

and sulfacetamide topical

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • silver nitrate

                  silver nitrate decreases effects of sulfacetamide topical by Other (see comment). Use Caution/Monitor. Comment: Topical preparations are physically incompatible.

                Minor (0)

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                  Adverse Effects

                  1-10%

                  Erythema

                  Itching

                  Edema

                  Local irritation

                  Stinging

                  Burning

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Cautions

                  Avoid contact with eyes or mucous membranes

                  Severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias reported

                  Avoid UV exposure

                  Contains sodium metabisulfite that is known to cause allergic reactions

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: not known whether excreted in breast milk, use caution

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Para-aminobenzoic acid (PABA) inhibitor; restricts folic acid synthesis required for bacterial growth

                  Absorption

                  4%

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                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  Klaron topical
                  -
                  10 % suspension
                  sulfacetamide sodium (acne) topical
                  -
                  10 % suspension
                  sulfacetamide sodium (acne) topical
                  -
                  10 % suspension

                  Copyright © 2010 First DataBank, Inc.

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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

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                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.