Dosing & Uses
Dosage Forms & Strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
Klaron: Apply thin film topically to affected areas BID
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
Ovace Plus Cream: Apply to affeted areas BID x8-10 days
Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Dosage Forms & Strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
<12 years: Safety and efficacy not established
Klaron ≥12 years: Apply thin film topically to affected areas BID
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
<12 years: Safety and efficacy not established
≥12 years
- Ovace Plus Cream: Apply to affeted areas BID x8-10 days
- Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
- For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
- Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (1)
- silver nitrate
silver nitrate decreases effects of sulfacetamide topical by Other (see comment). Use Caution/Monitor. Comment: Topical preparations are physically incompatible.
Minor (0)
Adverse Effects
1-10%
Erythema
Itching
Edema
Local irritation
Stinging
Burning
Warnings
Contraindications
Hypersensitivity
Cautions
Avoid contact with eyes or mucous membranes
Severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias reported
Avoid UV exposure
Contains sodium metabisulfite that is known to cause allergic reactions
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known whether excreted in breast milk, use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Para-aminobenzoic acid (PABA) inhibitor; restricts folic acid synthesis required for bacterial growth
Absorption
4%
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
Klaron topical - | 10 % suspension | ![]() | |
sulfacetamide sodium (acne) topical - | 10 % suspension | ![]() | |
sulfacetamide sodium (acne) topical - | 10 % suspension | ![]() |
Copyright © 2010 First DataBank, Inc.
Formulary
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