Dosing & Uses
Dosage Forms & Strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
Klaron: Apply thin film topically to affected areas BID
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
Ovace Plus Cream: Apply to affeted areas BID x8-10 days
Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Dosage Forms & Strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
<12 years: Safety and efficacy not established
Klaron ≥12 years: Apply thin film topically to affected areas BID
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
<12 years: Safety and efficacy not established
≥12 years
- Ovace Plus Cream: Apply to affeted areas BID x8-10 days
- Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
- For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
- Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
1-10%
Erythema
Itching
Edema
Local irritation
Stinging
Burning
Warnings
Contraindications
Hypersensitivity
Cautions
Avoid contact with eyes or mucous membranes
Severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias reported
Avoid UV exposure
Contains sodium metabisulfite that is known to cause allergic reactions
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known whether excreted in breast milk, use caution
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Mechanism of Action
Para-aminobenzoic acid (PABA) inhibitor; restricts folic acid synthesis required for bacterial growth
Absorption
4%
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
