Dosing & Uses
Dosage Forms & Strengths
liquid
- 100%
Constipation
15-45 mL/day PO, single or divided doses
Kondremul: 30-75 mL/day
Dosage Forms & Strengths
liquid
- 100%
Constipation
<6 years
- 15-30 mL/year of age; not to exceed 240 mL/day
6-12 years
- 5-15 mL/day divided qDay, single or divided doses
- Kondremul: 10-25 mL/day
>12 years
- 15-45 mL/day PO, single or divided doses
- Kondremul: 30-75 mL/day
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Adverse Effects
Frequency Not Defined
Lipid pneumonitis if reclined
Incontinence of feces
Intestinal malabsorption
Impaired absorption of fat-soluble vitamins
Rectal discharge
Anal pruritus and irritation
Abdominal cramps
Nausea
Vomiting
Lipid pneumonitis with aspiration
Warnings
Contraindications
Abdominal pain, nausea, vomiting, or other symptoms of appendicitis or acute surgical abdomen
Fecal impaction, intestinal obstruction or perforation, colostomy, ileostomy, ulcerative colitis, diverticulitis
Bedridden, geriatric, debilitated, or pregnant pts
Patients with esophageal or gastric retention, dysphagia, or hiatal hernia
Cautions
Conditions that interfere with swallowing or epiglottal function may increase risk of aspiration, which can result in lipid pneumonitis
Do not administer >1 week
Aspiration risk increases in the elderly
Pregnancy & Lactation
Pregnancy Category: Not recommended (no FDA risk factor assigned)
Lactation: Not known if excreted in breast milk; not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Emollient; retards colonic absorption of water; decreases water absorption and lubricates intestine, which eases passage of stool
Pharmacokinetics
Onset of action: 6-8 hr (PO)
Distribution: Colon
Excretion: Feces
Absorption: minimal