Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 65mcg/1.3mL
Pruritus
Indicated for moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis (HD)
0.5 mcg/kg IV push into venous line of dialysis circuit at the end of each HD treatment
Dosage Modifications
Hepatic impairment
- Mild-to-moderate: No dosage adjustment needed
- Severe: Pharmacokinetics not evaluated; use not recommended
Dosing Considerations
Limitation of use
- Not studied in patients on peritoneal dialysis; use not recommended
Safety and efficacy not established
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (2)
- olopatadine intranasal
difelikefalin and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- ropeginterferon alfa 2b
ropeginterferon alfa 2b and difelikefalin both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.
Monitor Closely (219)
- acetazolamide
difelikefalin and acetazolamide both increase sedation. Use Caution/Monitor.
- alfentanil
difelikefalin and alfentanil both increase sedation. Use Caution/Monitor.
- alprazolam
difelikefalin and alprazolam both increase sedation. Use Caution/Monitor.
- amantadine
difelikefalin and amantadine both increase sedation. Use Caution/Monitor.
- amitriptyline
difelikefalin and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
difelikefalin and amobarbital both increase sedation. Use Caution/Monitor.
- amoxapine
difelikefalin and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
difelikefalin and apomorphine both increase sedation. Use Caution/Monitor.
- arbaclofen
difelikefalin and arbaclofen both increase sedation. Use Caution/Monitor.
- aripiprazole
difelikefalin and aripiprazole both increase sedation. Use Caution/Monitor.
- asenapine
difelikefalin and asenapine both increase sedation. Use Caution/Monitor.
- asenapine transdermal
difelikefalin and asenapine transdermal both increase sedation. Use Caution/Monitor.
- baclofen
difelikefalin and baclofen both increase sedation. Use Caution/Monitor.
- belladonna and opium
difelikefalin and belladonna and opium both increase sedation. Use Caution/Monitor.
- benzhydrocodone/acetaminophen
difelikefalin and benzhydrocodone/acetaminophen both increase sedation. Use Caution/Monitor.
- brexanolone
difelikefalin and brexanolone both increase sedation. Use Caution/Monitor.
- brexpiprazole
difelikefalin and brexpiprazole both increase sedation. Use Caution/Monitor.
- bromocriptine
difelikefalin and bromocriptine both increase sedation. Use Caution/Monitor.
- brompheniramine
difelikefalin and brompheniramine both increase sedation. Use Caution/Monitor.
- buprenorphine
difelikefalin and buprenorphine both increase sedation. Use Caution/Monitor.
- buprenorphine transdermal
difelikefalin and buprenorphine transdermal both increase sedation. Use Caution/Monitor.
- bupropion
difelikefalin and bupropion both increase sedation. Use Caution/Monitor.
- buspirone
difelikefalin and buspirone both increase sedation. Use Caution/Monitor.
- butabarbital
difelikefalin and butabarbital both increase sedation. Use Caution/Monitor.
- butalbital
difelikefalin and butalbital both increase sedation. Use Caution/Monitor.
- butorphanol
difelikefalin and butorphanol both increase sedation. Use Caution/Monitor.
- carbamazepine
difelikefalin and carbamazepine both increase sedation. Use Caution/Monitor.
- carbinoxamine
difelikefalin and carbinoxamine both increase sedation. Use Caution/Monitor.
- cariprazine
difelikefalin and cariprazine both increase sedation. Use Caution/Monitor.
- carisoprodol
difelikefalin and carisoprodol both increase sedation. Use Caution/Monitor.
- cenobamate
difelikefalin and cenobamate both increase sedation. Use Caution/Monitor.
- chloral hydrate
difelikefalin and chloral hydrate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
difelikefalin and chlordiazepoxide both increase sedation. Use Caution/Monitor.
- chlorpheniramine
difelikefalin and chlorpheniramine both increase sedation. Use Caution/Monitor.
- chlorpromazine
difelikefalin and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorzoxazone
difelikefalin and chlorzoxazone both increase sedation. Use Caution/Monitor.
- citalopram
difelikefalin and citalopram both increase sedation. Use Caution/Monitor.
- clemastine
difelikefalin and clemastine both increase sedation. Use Caution/Monitor.
- clobazam
difelikefalin and clobazam both increase sedation. Use Caution/Monitor.
- clomipramine
difelikefalin and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
difelikefalin and clonazepam both increase sedation. Use Caution/Monitor.
- clonidine
difelikefalin and clonidine both increase sedation. Use Caution/Monitor.
- clorazepate
difelikefalin and clorazepate both increase sedation. Use Caution/Monitor.
- clozapine
difelikefalin and clozapine both increase sedation. Use Caution/Monitor.
- codeine
difelikefalin and codeine both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
difelikefalin and cyclobenzaprine both increase sedation. Use Caution/Monitor.
- cyproheptadine
difelikefalin and cyproheptadine both increase sedation. Use Caution/Monitor.
- dantrolene
difelikefalin and dantrolene both increase sedation. Use Caution/Monitor.
- daridorexant
difelikefalin and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desflurane
difelikefalin and desflurane both increase sedation. Use Caution/Monitor.
- desipramine
difelikefalin and desipramine both increase sedation. Use Caution/Monitor.
- desvenlafaxine
difelikefalin and desvenlafaxine both increase sedation. Use Caution/Monitor.
- deutetrabenazine
difelikefalin and deutetrabenazine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
difelikefalin and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- dexmedetomidine
difelikefalin and dexmedetomidine both increase sedation. Use Caution/Monitor.
- diazepam
difelikefalin and diazepam both increase sedation. Use Caution/Monitor.
- diazepam buccal
difelikefalin and diazepam buccal both increase sedation. Use Caution/Monitor.
- diazepam intranasal
difelikefalin and diazepam intranasal both increase sedation. Use Caution/Monitor.
- dichloralphenazone
difelikefalin and dichloralphenazone both increase sedation. Use Caution/Monitor.
- dichlorphenamide
difelikefalin and dichlorphenamide both increase sedation. Use Caution/Monitor.
- difenoxin hcl
difelikefalin and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
difelikefalin and dimenhydrinate both increase sedation. Use Caution/Monitor.
- diphenhydramine
difelikefalin and diphenhydramine both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
difelikefalin and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- divalproex sodium
difelikefalin and divalproex sodium both increase sedation. Use Caution/Monitor.
- doxepin
difelikefalin and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
difelikefalin and doxylamine both increase sedation. Use Caution/Monitor.
- dronabinol
difelikefalin and dronabinol both increase sedation. Use Caution/Monitor.
- droperidol
difelikefalin and droperidol both increase sedation. Use Caution/Monitor.
- duloxetine
difelikefalin and duloxetine both increase sedation. Use Caution/Monitor.
- efavirenz
difelikefalin and efavirenz both increase sedation. Use Caution/Monitor.
- entacapone
difelikefalin and entacapone both increase sedation. Use Caution/Monitor.
- escitalopram
difelikefalin and escitalopram both increase sedation. Use Caution/Monitor.
- esketamine intranasal
difelikefalin and esketamine intranasal both increase sedation. Use Caution/Monitor.
- eslicarbazepine acetate
difelikefalin and eslicarbazepine acetate both increase sedation. Use Caution/Monitor.
- estazolam
difelikefalin and estazolam both increase sedation. Use Caution/Monitor.
- eszopiclone
difelikefalin and eszopiclone both increase sedation. Use Caution/Monitor.
- ethosuximide
difelikefalin and ethosuximide both increase sedation. Use Caution/Monitor.
- ethotoin
difelikefalin and ethotoin both increase sedation. Use Caution/Monitor.
- etomidate
difelikefalin and etomidate both increase sedation. Use Caution/Monitor.
- felbamate
difelikefalin and felbamate both increase sedation. Use Caution/Monitor.
- fenfluramine
difelikefalin and fenfluramine both increase sedation. Use Caution/Monitor.
- fentanyl
difelikefalin and fentanyl both increase sedation. Use Caution/Monitor.
- fentanyl intranasal
difelikefalin and fentanyl intranasal both increase sedation. Use Caution/Monitor.
- fentanyl iontophoretic transdermal system
difelikefalin and fentanyl iontophoretic transdermal system both increase sedation. Use Caution/Monitor.
- fentanyl transdermal
difelikefalin and fentanyl transdermal both increase sedation. Use Caution/Monitor.
- fentanyl transmucosal
difelikefalin and fentanyl transmucosal both increase sedation. Use Caution/Monitor.
- flibanserin
difelikefalin and flibanserin both increase sedation. Use Caution/Monitor.
- fluoxetine
difelikefalin and fluoxetine both increase sedation. Use Caution/Monitor.
- fluphenazine
difelikefalin and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
difelikefalin and flurazepam both increase sedation. Use Caution/Monitor.
- fluvoxamine
difelikefalin and fluvoxamine both increase sedation. Use Caution/Monitor.
- fosphenytoin
difelikefalin and fosphenytoin both increase sedation. Use Caution/Monitor.
- gabapentin
difelikefalin and gabapentin both increase sedation. Use Caution/Monitor.
- gabapentin enacarbil
difelikefalin and gabapentin enacarbil both increase sedation. Use Caution/Monitor.
- gepirone
difelikefalin and gepirone both increase sedation. Use Caution/Monitor.
- guanabenz
difelikefalin and guanabenz both increase sedation. Use Caution/Monitor.
- guanfacine
difelikefalin and guanfacine both increase sedation. Use Caution/Monitor.
- haloperidol
difelikefalin and haloperidol both increase sedation. Use Caution/Monitor.
- hydrocodone
difelikefalin and hydrocodone both increase sedation. Use Caution/Monitor.
- hydromorphone
difelikefalin and hydromorphone both increase sedation. Use Caution/Monitor.
- hydroxyzine
difelikefalin and hydroxyzine both increase sedation. Use Caution/Monitor.
- iloperidone
difelikefalin and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
difelikefalin and imipramine both increase sedation. Use Caution/Monitor.
- isoflurane
difelikefalin and isoflurane both increase sedation. Use Caution/Monitor.
- ketamine
difelikefalin and ketamine both increase sedation. Use Caution/Monitor.
- lacosamide
difelikefalin and lacosamide both increase sedation. Use Caution/Monitor.
- lamotrigine
difelikefalin and lamotrigine both increase sedation. Use Caution/Monitor.
- levodopa
difelikefalin and levodopa both increase sedation. Use Caution/Monitor.
- levorphanol
difelikefalin and levorphanol both increase sedation. Use Caution/Monitor.
- lithium
difelikefalin and lithium both increase sedation. Use Caution/Monitor.
- lorazepam
difelikefalin and lorazepam both increase sedation. Use Caution/Monitor.
- loxapine
difelikefalin and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
difelikefalin and loxapine inhaled both increase sedation. Use Caution/Monitor.
- loxicodegol
difelikefalin and loxicodegol both increase sedation. Use Caution/Monitor.
- lumateperone
difelikefalin and lumateperone both increase sedation. Use Caution/Monitor.
- lurasidone
difelikefalin and lurasidone both increase sedation. Use Caution/Monitor.
- maprotiline
difelikefalin and maprotiline both increase sedation. Use Caution/Monitor.
- meclizine
difelikefalin and meclizine both increase sedation. Use Caution/Monitor.
- meperidine
difelikefalin and meperidine both increase sedation. Use Caution/Monitor.
- mephobarbital
difelikefalin and mephobarbital both increase sedation. Use Caution/Monitor.
- meprobamate
difelikefalin and meprobamate both increase sedation. Use Caution/Monitor.
- metaxalone
difelikefalin and metaxalone both increase sedation. Use Caution/Monitor.
- methadone
difelikefalin and methadone both increase sedation. Use Caution/Monitor.
- methocarbamol
difelikefalin and methocarbamol both increase sedation. Use Caution/Monitor.
- methohexital
difelikefalin and methohexital both increase sedation. Use Caution/Monitor.
- methsuximide
difelikefalin and methsuximide both increase sedation. Use Caution/Monitor.
- methyldopa
difelikefalin and methyldopa both increase sedation. Use Caution/Monitor.
- metyrosine
difelikefalin and metyrosine both increase sedation. Use Caution/Monitor.
- midazolam
difelikefalin and midazolam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
difelikefalin and midazolam intranasal both increase sedation. Use Caution/Monitor.
- mirtazapine
difelikefalin and mirtazapine both increase sedation. Use Caution/Monitor.
- molindone
difelikefalin and molindone both increase sedation. Use Caution/Monitor.
- morphine
difelikefalin and morphine both increase sedation. Use Caution/Monitor.
- nabilone
difelikefalin and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
difelikefalin and nalbuphine both increase sedation. Use Caution/Monitor.
- nefazodone
difelikefalin and nefazodone both increase sedation. Use Caution/Monitor.
- nitrous oxide
difelikefalin and nitrous oxide both increase sedation. Use Caution/Monitor.
- nortriptyline
difelikefalin and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
difelikefalin and olanzapine both increase sedation. Use Caution/Monitor.
- oliceridine
difelikefalin and oliceridine both increase sedation. Use Caution/Monitor.
- opium tincture
difelikefalin and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
difelikefalin and orphenadrine both increase sedation. Use Caution/Monitor.
- oxazepam
difelikefalin and oxazepam both increase sedation. Use Caution/Monitor.
- oxcarbazepine
difelikefalin and oxcarbazepine both increase sedation. Use Caution/Monitor.
- oxybutynin
difelikefalin and oxybutynin both increase sedation. Use Caution/Monitor.
- oxycodone
difelikefalin and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
difelikefalin and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
difelikefalin and paliperidone both increase sedation. Use Caution/Monitor.
- paregoric
difelikefalin and paregoric both increase sedation. Use Caution/Monitor.
- paroxetine
difelikefalin and paroxetine both increase sedation. Use Caution/Monitor.
- pentazocine
difelikefalin and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
difelikefalin and pentobarbital both increase sedation. Use Caution/Monitor.
- perampanel
difelikefalin and perampanel both increase sedation. Use Caution/Monitor.
- perphenazine
difelikefalin and perphenazine both increase sedation. Use Caution/Monitor.
- pheniramine
difelikefalin and pheniramine both increase sedation. Use Caution/Monitor.
- phenobarbital
difelikefalin and phenobarbital both increase sedation. Use Caution/Monitor.
- phenytoin
difelikefalin and phenytoin both increase sedation. Use Caution/Monitor.
- pimavanserin
difelikefalin and pimavanserin both increase sedation. Use Caution/Monitor.
- pimozide
difelikefalin and pimozide both increase sedation. Use Caution/Monitor.
- pramipexole
difelikefalin and pramipexole both increase sedation. Use Caution/Monitor.
- pregabalin
difelikefalin and pregabalin both increase sedation. Use Caution/Monitor.
- primidone
difelikefalin and primidone both increase sedation. Use Caution/Monitor.
- prochlorperazine
difelikefalin and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
difelikefalin and promethazine both increase sedation. Use Caution/Monitor.
- propofol
difelikefalin and propofol both increase sedation. Use Caution/Monitor.
- protriptyline
difelikefalin and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
difelikefalin and quazepam both increase sedation. Use Caution/Monitor.
- quetiapine
difelikefalin and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
difelikefalin and ramelteon both increase sedation. Use Caution/Monitor.
- rasagiline
difelikefalin and rasagiline both increase sedation. Use Caution/Monitor.
- remifentanil
difelikefalin and remifentanil both increase sedation. Use Caution/Monitor.
- remimazolam
difelikefalin and remimazolam both increase sedation. Use Caution/Monitor.
- risperidone
difelikefalin and risperidone both increase sedation. Use Caution/Monitor.
- ropinirole
difelikefalin and ropinirole both increase sedation. Use Caution/Monitor.
- rotigotine
difelikefalin and rotigotine both increase sedation. Use Caution/Monitor.
- rufinamide
difelikefalin and rufinamide both increase sedation. Use Caution/Monitor.
- safinamide
difelikefalin and safinamide both increase sedation. Use Caution/Monitor.
- samidorphan
difelikefalin and samidorphan both increase sedation. Use Caution/Monitor.
- scopolamine
difelikefalin and scopolamine both increase sedation. Use Caution/Monitor.
- secobarbital
difelikefalin and secobarbital both increase sedation. Use Caution/Monitor.
- selegiline
difelikefalin and selegiline both increase sedation. Use Caution/Monitor.
- selegiline transdermal
difelikefalin and selegiline transdermal both increase sedation. Use Caution/Monitor.
- sertraline
difelikefalin and sertraline both increase sedation. Use Caution/Monitor.
- sevoflurane
difelikefalin and sevoflurane both increase sedation. Use Caution/Monitor.
- sodium oxybate
difelikefalin and sodium oxybate both increase sedation. Use Caution/Monitor.
- stiripentol
difelikefalin and stiripentol both increase sedation. Use Caution/Monitor.
- sufentanil
difelikefalin and sufentanil both increase sedation. Use Caution/Monitor.
- sufentanil SL
difelikefalin and sufentanil SL both increase sedation. Use Caution/Monitor.
- suvorexant
difelikefalin and suvorexant both increase sedation. Use Caution/Monitor.
- tapentadol
difelikefalin and tapentadol both increase sedation. Use Caution/Monitor.
- tasimelteon
difelikefalin and tasimelteon both increase sedation. Use Caution/Monitor.
- temazepam
difelikefalin and temazepam both increase sedation. Use Caution/Monitor.
- tetrabenazine
difelikefalin and tetrabenazine both increase sedation. Use Caution/Monitor.
- thalidomide
difelikefalin and thalidomide both increase sedation. Use Caution/Monitor.
- theophylline
difelikefalin and theophylline both increase sedation. Use Caution/Monitor.
- thioridazine
difelikefalin and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
difelikefalin and thiothixene both increase sedation. Use Caution/Monitor.
- tiagabine
difelikefalin and tiagabine both increase sedation. Use Caution/Monitor.
- tizanidine
difelikefalin and tizanidine both increase sedation. Use Caution/Monitor.
- tolcapone
difelikefalin and tolcapone both increase sedation. Use Caution/Monitor.
- topiramate
difelikefalin and topiramate both increase sedation. Use Caution/Monitor.
- tramadol
difelikefalin and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
difelikefalin and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
difelikefalin and triazolam both increase sedation. Use Caution/Monitor.
- trifluoperazine
difelikefalin and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimethobenzamide
difelikefalin and trimethobenzamide both increase sedation. Use Caution/Monitor.
- trimipramine
difelikefalin and trimipramine both increase sedation. Use Caution/Monitor.
- triprolidine
difelikefalin and triprolidine both increase sedation. Use Caution/Monitor.
- valerian
difelikefalin and valerian both increase sedation. Use Caution/Monitor.
- valproic acid
difelikefalin and valproic acid both increase sedation. Use Caution/Monitor.
- vigabatrin
difelikefalin and vigabatrin both increase sedation. Use Caution/Monitor.
- vilazodone
difelikefalin and vilazodone both increase sedation. Use Caution/Monitor.
- vortioxetine
difelikefalin and vortioxetine both increase sedation. Use Caution/Monitor.
- zaleplon
difelikefalin and zaleplon both increase sedation. Use Caution/Monitor.
- zileuton
difelikefalin and zileuton both increase sedation. Use Caution/Monitor.
- ziprasidone
difelikefalin and ziprasidone both increase sedation. Use Caution/Monitor.
- zolpidem
difelikefalin and zolpidem both increase sedation. Use Caution/Monitor.
- zonisamide
difelikefalin and zonisamide both increase sedation. Use Caution/Monitor.
Minor (0)
Adverse Effects
1-10%
Diarrhea (9%)
Dizziness (6.8%)
Nausea (6.6%)
Gait disturbances (6.6%)
Hyperkalemia (4.7%)
Headache (4.5%)
Somnolence (4.2%)
Mental status change (3.3%)
Warnings
Contraindications
None
Cautions
Dizziness, somnolence, mental status changes, and gait disturbances (eg, falls) have occurred; may subside over time with continued treatment
May impair mental or physical abilities; advise patients not to drive or operate dangerous machinery until effect on a patient’s ability to drive or operate machinery is known
Drug interaction overview
- Centrally acting depressant medications, sedating antihistamines, and opioid analgesics may increase the adverse reactions of difelikefalin; use with caution
Pregnancy & Lactation
Pregnancy
Limited human data are insufficient on use in pregnant females to evaluate drug-associated risks for major birth defects or miscarriage
Lactation
There are no data regarding drug presence in human milk, effects on breastfed infants, or effects on milk production
Studies showed difelikefalin was transferred into milk in lactating rats
When a drug is present in animal milk, it is likely that the drug will be present in human milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Kappa opioid receptor (KOR) agonist
Relevance of KOR activation to therapeutic effectiveness is unknown
Absorption
Steady-state was reached after second dose
Mean accumulation ratio: 1.6
Distribution
Vd: 238 mL/kg
Protein bound: 23-28%
Elimination
Half-life (before dialysis): 23-31 hr
Excretion: Urine (11%); feces (59%); dialysate fluid (20%)
Administration
IV Preparation
Do not mix or dilute before administration
Visually inspect vials for particulate matter and discoloration before administering; solution should be clear and colorless; discard vials if particulate matter or discoloration is observed
Vials are for single-dose use; discard any unused product
May use the following formula to determine total injection volume on target body weight or may refer to prescribing information
Total injection volume (mL) = Patient target dry body weight (kg) x 0.01, rounded to the nearest tenth (0.1 mL)
IV Administration
Administer after blood is no longer circulating through the dialyzer; dialyzer membrane removes difelikefalin
Administer IV push into venous line of the dialysis circuit at the end of each HD session
May be given either during or after rinse back of dialysis circuit
Dose given after rinse back: Administer into venous line followed by ≥10 mL of 0.9% NaCl flush
Dose given during rinse back: No additional 0.9% NaCl is needed to flush line
Administer within 60 minutes of syringe preparation; discard any unused product
Missed regularly scheduled HD treatment: Resume at the end of next HD treatment
Storage
Unopened vials
- Store at 20-25ºC (68-77ºF); excursions permitted to 15-30ºC (59-86ºF)
- Do not freeze
Prepared syringe
- Store at 20-25ºC (68-77ºF); discard after 60 minutes of syringe preparation
Images
Formulary
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