potassium acid phosphate (Rx)

Frequency Not Defined

Diarrhea

Nausea/vomiting

Stomach pain

Flatulence

Bradycardia

Hyperkalemia

Local tissue necrosis with extravasation

Weakness

Dyspnea

Hypocalcemia

Tetany

Phosphate intoxication

Hypotension

Arrhythmia

Contraindications

Hyperphosphatemia, severe renal impairment, hyperkalemia, infected phophate stones

Cautions

May cause hyperkalemia; use caution in patients who require regulation of serum potassium concentrations

Patients may experience mild laxative effects within first few days of therapy

Use caution in patients with severe adrenal insufficiency, cardiac disease, myotonia congenita, pancreatitis, parathyroid disease, renal calculi, renal impairment, tissue breakdowns (burns), or rickets

Pregnancy Category: C

Lactation: Use with caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Intracellular cation essential in physiological processes including transmission of nerve impulses, glucose utilization, muscle contractions, and enzyme activity

Acidifies urine

Pharmacokinetics

Distribution: Enters cells from extracellular fluid via active transport

Absorption: Well absorbed from upper GI tract

Excretion: Urine (primarily); skin and feces (small amount)