Pau D'arco (Herb/Suppl)

Brand and Other Names:La Pacho, Tabebuia avellanedae
  • Print

Suggested Dosing

1-4 g/d div BID-TID, use not more than 7d

1 tsp bark steeped in boiling water, 2-8 x/day

Dose based on lapachol content; lapachol intake should be 1.5-2.0 g/day

Next:

Suggested Uses

Antimicrobial, especially anti-Candida

Claimed to be anti-cancer

Efficacy

Insufficient reliable data available

Previous
Next:

Interactions

Interaction Checker

and Pau D'arco

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (68)

                • aceclofenac

                  aceclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • American ginseng

                  American ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  garlic and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ginger

                  ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  ginkgo biloba and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  horse chestnut seed and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  pau d'arco increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • nettle

                  pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  panax ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  pau d'arco and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • piroxicam

                  piroxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  pau d'arco and reishi both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • Siberian ginseng

                  pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  pau d'arco increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                Minor (3)

                • anamu

                  anamu and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

                • danshen

                  danshen and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

                Previous
                Next:

                Adverse Effects

                Frequency Not Defined

                Nausea

                Vomiting

                Dizziness

                Anti-coagulant effects (reduced by using whole bark)

                Previous
                Next:

                Warnings

                Contraindications

                N/A

                Cautions

                Products highly variable in lapachol content

                Negative anti-cancer results found by NCI based on isolated lapachol; whole bark contains synergistic compounds that reduce ADR's

                Previous
                Next:

                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

                Previous
                Next:

                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Antimicrobial

                Previous
                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.