Suggested Dosing
1-4 g/d div BID-TID, use not more than 7d
1 tsp bark steeped in boiling water, 2-8 x/day
Dose based on lapachol content; lapachol intake should be 1.5-2.0 g/day
Suggested Uses
Antimicrobial, especially anti-Candida
Claimed to be anti-cancer
Efficacy
Insufficient reliable data available
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (68)
- aceclofenac
aceclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- acemetacin
acemetacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- agrimony
agrimony and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- alfalfa
alfalfa and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- American ginseng
American ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- antithrombin alfa
antithrombin alfa and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- antithrombin III
antithrombin III and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- argatroban
argatroban and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- aspirin
aspirin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- aspirin rectal
aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- bemiparin
bemiparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- bivalirudin
bivalirudin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- celecoxib
celecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- choline magnesium trisalicylate
choline magnesium trisalicylate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- cinnamon
cinnamon and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- cordyceps
cordyceps and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- dabigatran
dabigatran and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- dalteparin
dalteparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- diclofenac
diclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- diflunisal
diflunisal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- dong quai
dong quai and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- enoxaparin
enoxaparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- epoprostenol
epoprostenol and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- etodolac
etodolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- fennel
fennel and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- fenoprofen
fenoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- feverfew
feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- flurbiprofen
flurbiprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- fondaparinux
fondaparinux and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- forskolin
forskolin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- garlic
garlic and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ginger
ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ginkgo biloba
ginkgo biloba and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- heparin
heparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- horse chestnut seed
horse chestnut seed and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ibuprofen
ibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ibuprofen IV
ibuprofen IV and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- indomethacin
indomethacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ketoprofen
ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ketorolac
ketorolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- ketorolac intranasal
ketorolac intranasal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- lornoxicam
lornoxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- meclofenamate
meclofenamate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- mefenamic acid
mefenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- meloxicam
meloxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- mistletoe
pau d'arco increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nabumetone
nabumetone and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- naproxen
naproxen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- nettle
pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- oxaprozin
oxaprozin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- panax ginseng
panax ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- parecoxib
parecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- phenindione
phenindione and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- phytoestrogens
pau d'arco and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
- piroxicam
piroxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- protamine
protamine and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- reishi
pau d'arco and reishi both increase anticoagulation. Use Caution/Monitor.
- reteplase
reteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- salicylates (non-asa)
salicylates (non-asa) and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- salsalate
salsalate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- Siberian ginseng
pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- sulfasalazine
sulfasalazine and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- sulindac
sulindac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- tenecteplase
tenecteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
- tolfenamic acid
tolfenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- tolmetin
tolmetin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- vitamin K1 (phytonadione)
pau d'arco increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Minor (3)
- anamu
anamu and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
- danshen
danshen and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
- devil's claw
devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Nausea
Vomiting
Dizziness
Anti-coagulant effects (reduced by using whole bark)
Warnings
Contraindications
N/A
Cautions
Products highly variable in lapachol content
Negative anti-cancer results found by NCI based on isolated lapachol; whole bark contains synergistic compounds that reduce ADR's
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Antimicrobial