Indication-specific dosing for La Pacho, Tabebuia avellanedae (pau d'arco), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Pau D'arco
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

1-4 g/d div BID-TID, use not more than 7d

1 tsp bark steeped in boiling water, 2-8 x/day

Dose based on lapachol content; lapachol intake should be 1.5-2.0 g/day

Suggested Uses

Antimicrobial, especially anti-Candida

Claimed to be anti-cancer

Efficacy

Insufficient reliable data available

Interaction Checker

Enter a drug name and Pau D'arco

No Results

No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

All Interactions Sort By:

Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (68)

aceclofenac
aceclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
acemetacin
acemetacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
agrimony
agrimony and pau d'arco both increase anticoagulation. Use Caution/Monitor.
alfalfa
alfalfa and pau d'arco both increase anticoagulation. Use Caution/Monitor.
American ginseng
American ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
antithrombin alfa
antithrombin alfa and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
antithrombin III and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
argatroban and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
aspirin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
aspirin rectal
aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
bemiparin
bemiparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
bivalirudin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
celecoxib
celecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
choline magnesium trisalicylate
choline magnesium trisalicylate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
cinnamon
cinnamon and pau d'arco both increase anticoagulation. Use Caution/Monitor.
cordyceps
cordyceps and pau d'arco both increase anticoagulation. Use Caution/Monitor.
dabigatran
dabigatran and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
dalteparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
diclofenac
diclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
diflunisal
diflunisal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
dong quai
dong quai and pau d'arco both increase anticoagulation. Use Caution/Monitor.
enoxaparin
enoxaparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
epoprostenol and pau d'arco both increase anticoagulation. Use Caution/Monitor.
etodolac
etodolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fennel
fennel and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fenoprofen
fenoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
feverfew
feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
flurbiprofen
flurbiprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fondaparinux
fondaparinux and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
forskolin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
garlic
garlic and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ginger
ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
ginkgo biloba and pau d'arco both increase anticoagulation. Use Caution/Monitor.
heparin
heparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
horse chestnut seed and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ibuprofen
ibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ibuprofen IV
ibuprofen IV and pau d'arco both increase anticoagulation. Use Caution/Monitor.
indomethacin
indomethacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketoprofen
ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketorolac
ketorolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketorolac intranasal
ketorolac intranasal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
lornoxicam
lornoxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
meclofenamate
meclofenamate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
mefenamic acid
mefenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
meloxicam
meloxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
mistletoe
pau d'arco increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
nabumetone and pau d'arco both increase anticoagulation. Use Caution/Monitor.
naproxen
naproxen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
nettle
pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
oxaprozin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
panax ginseng
panax ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
parecoxib
parecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
phenindione and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
pau d'arco and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
piroxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
protamine
protamine and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
pau d'arco and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
reteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
salicylates (non-asa) and pau d'arco both increase anticoagulation. Use Caution/Monitor.
salsalate
salsalate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
Siberian ginseng
pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
sulfasalazine and pau d'arco both increase anticoagulation. Use Caution/Monitor.
sulindac
sulindac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
tenecteplase
tenecteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
tolfenamic acid
tolfenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
tolmetin
tolmetin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
vitamin K1 (phytonadione)
pau d'arco increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Minor (3)

anamu
anamu and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
danshen
danshen and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
devil's claw
devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

aceclofenac
Monitor Closely (1)aceclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
acemetacin
Monitor Closely (1)acemetacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
agrimony
Monitor Closely (1)agrimony and pau d'arco both increase anticoagulation. Use Caution/Monitor.
alfalfa
Monitor Closely (1)alfalfa and pau d'arco both increase anticoagulation. Use Caution/Monitor.
American ginseng
Monitor Closely (1)American ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
anamu
Minor (1)anamu and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
antithrombin alfa
Monitor Closely (1)antithrombin alfa and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
Monitor Closely (1)antithrombin III and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
Monitor Closely (1)argatroban and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
Monitor Closely (1)aspirin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
aspirin rectal
Monitor Closely (1)aspirin rectal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
aspirin/citric acid/sodium bicarbonate
Monitor Closely (1)aspirin/citric acid/sodium bicarbonate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
bemiparin
Monitor Closely (1)bemiparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
Monitor Closely (1)bivalirudin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
celecoxib
Monitor Closely (1)celecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
choline magnesium trisalicylate
Monitor Closely (1)choline magnesium trisalicylate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
cinnamon
Monitor Closely (1)cinnamon and pau d'arco both increase anticoagulation. Use Caution/Monitor.
cordyceps
Monitor Closely (1)cordyceps and pau d'arco both increase anticoagulation. Use Caution/Monitor.
dabigatran
Monitor Closely (1)dabigatran and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
Monitor Closely (1)dalteparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
danshen
Minor (1)danshen and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
devil's claw
Minor (1)devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.
diclofenac
Monitor Closely (1)diclofenac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
diflunisal
Monitor Closely (1)diflunisal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
dong quai
Monitor Closely (1)dong quai and pau d'arco both increase anticoagulation. Use Caution/Monitor.
enoxaparin
Monitor Closely (1)enoxaparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
Monitor Closely (1)epoprostenol and pau d'arco both increase anticoagulation. Use Caution/Monitor.
etodolac
Monitor Closely (1)etodolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fennel
Monitor Closely (1)fennel and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fenoprofen
Monitor Closely (1)fenoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
feverfew
Monitor Closely (1)feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
flurbiprofen
Monitor Closely (1)flurbiprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
fondaparinux
Monitor Closely (1)fondaparinux and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
Monitor Closely (1)forskolin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
garlic
Monitor Closely (1)garlic and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ginger
Monitor Closely (1)ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
Monitor Closely (1)ginkgo biloba and pau d'arco both increase anticoagulation. Use Caution/Monitor.
heparin
Monitor Closely (1)heparin and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
Monitor Closely (1)horse chestnut seed and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ibuprofen
Monitor Closely (1)ibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ibuprofen IV
Monitor Closely (1)ibuprofen IV and pau d'arco both increase anticoagulation. Use Caution/Monitor.
indomethacin
Monitor Closely (1)indomethacin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketoprofen
Monitor Closely (1)ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketorolac
Monitor Closely (1)ketorolac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
ketorolac intranasal
Monitor Closely (1)ketorolac intranasal and pau d'arco both increase anticoagulation. Use Caution/Monitor.
lornoxicam
Monitor Closely (1)lornoxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
meclofenamate
Monitor Closely (1)meclofenamate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
mefenamic acid
Monitor Closely (1)mefenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
meloxicam
Monitor Closely (1)meloxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
mistletoe
Monitor Closely (1)pau d'arco increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
Monitor Closely (1)nabumetone and pau d'arco both increase anticoagulation. Use Caution/Monitor.
naproxen
Monitor Closely (1)naproxen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
nettle
Monitor Closely (1)pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
Monitor Closely (1)oxaprozin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
panax ginseng
Monitor Closely (1)panax ginseng and pau d'arco both increase anticoagulation. Use Caution/Monitor.
parecoxib
Monitor Closely (1)parecoxib and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
Monitor Closely (1)phenindione and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
Monitor Closely (1)pau d'arco and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
Monitor Closely (1)piroxicam and pau d'arco both increase anticoagulation. Use Caution/Monitor.
protamine
Monitor Closely (1)protamine and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
Monitor Closely (1)pau d'arco and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
Monitor Closely (1)reteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
Monitor Closely (1)salicylates (non-asa) and pau d'arco both increase anticoagulation. Use Caution/Monitor.
salsalate
Monitor Closely (1)salsalate and pau d'arco both increase anticoagulation. Use Caution/Monitor.
Siberian ginseng
Monitor Closely (1)pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
Monitor Closely (1)sulfasalazine and pau d'arco both increase anticoagulation. Use Caution/Monitor.
sulindac
Monitor Closely (1)sulindac and pau d'arco both increase anticoagulation. Use Caution/Monitor.
tenecteplase
Monitor Closely (1)tenecteplase and pau d'arco both increase anticoagulation. Modify Therapy/Monitor Closely.
tolfenamic acid
Monitor Closely (1)tolfenamic acid and pau d'arco both increase anticoagulation. Use Caution/Monitor.
tolmetin
Monitor Closely (1)tolmetin and pau d'arco both increase anticoagulation. Use Caution/Monitor.
vitamin K1 (phytonadione)
Monitor Closely (1)pau d'arco increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Frequency Not Defined

Nausea

Vomiting

Dizziness

Anti-coagulant effects (reduced by using whole bark)

Contraindications

N/A

Cautions

Products highly variable in lapachol content

Negative anti-cancer results found by NCI based on isolated lapachol; whole bark contains synergistic compounds that reduce ADR's

Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Antimicrobial

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

[CLOSE WINDOW]

Sections Pau D'arco
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Pau D'arco (Herb/Suppl)