Suggested Dosing
Crushed herb: 4.5 g PO q30-60min (acute conditions); TID (chronic)
Other preparations: see mfr's directions
Suggested Uses
Arrhythmia, low cardiac output, delayed menstruation, metrorrhagia
Efficacy: Insufficient reliable evidence, may improve menstrual flow, has relaxing effect on heart
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (2)
- calcium/magnesium/potassium/sodium oxybates
motherwort, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sodium oxybate
motherwort, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (160)
- albuterol
motherwort increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and motherwort both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and motherwort both increase sedation. Use Caution/Monitor.
- amitriptyline
amitriptyline and motherwort both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and motherwort both increase sedation. Use Caution/Monitor.
- amoxapine
amoxapine and motherwort both increase sedation. Use Caution/Monitor.
- apomorphine
apomorphine and motherwort both increase sedation. Use Caution/Monitor.
- arformoterol
motherwort increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
aripiprazole and motherwort both increase sedation. Use Caution/Monitor.
- armodafinil
motherwort increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- azelastine
azelastine and motherwort both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and motherwort both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and motherwort both increase sedation. Use Caution/Monitor.
- benperidol
benperidol and motherwort both increase sedation. Use Caution/Monitor.
- benzphetamine
motherwort increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brompheniramine
brompheniramine and motherwort both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and motherwort both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and motherwort both increase sedation. Use Caution/Monitor.
- butabarbital
butabarbital and motherwort both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and motherwort both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and motherwort both increase sedation. Use Caution/Monitor.
- caffeine
motherwort increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and motherwort both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and motherwort both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and motherwort both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.
- chlorpromazine
chlorpromazine and motherwort both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and motherwort both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and motherwort both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and motherwort both increase sedation. Use Caution/Monitor.
- clomipramine
clomipramine and motherwort both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and motherwort both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and motherwort both increase sedation. Use Caution/Monitor.
- clozapine
clozapine and motherwort both increase sedation. Use Caution/Monitor.
- codeine
codeine and motherwort both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and motherwort both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and motherwort both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and motherwort both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and motherwort both increase sedation. Use Caution/Monitor.
- desipramine
desipramine and motherwort both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.
- dexfenfluramine
motherwort increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and motherwort both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
motherwort increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
motherwort increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and motherwort both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and motherwort both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and motherwort both increase sedation. Use Caution/Monitor.
- diethylpropion
motherwort increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and motherwort both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and motherwort both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and motherwort both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and motherwort both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and motherwort both increase sedation. Use Caution/Monitor.
- dobutamine
motherwort increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
motherwort increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
motherwort increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- doxepin
doxepin and motherwort both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and motherwort both increase sedation. Use Caution/Monitor.
- droperidol
droperidol and motherwort both increase sedation. Use Caution/Monitor.
- ephedrine
motherwort increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
motherwort increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
motherwort increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- estazolam
estazolam and motherwort both increase sedation. Use Caution/Monitor.
- ethanol
ethanol and motherwort both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and motherwort both increase sedation. Use Caution/Monitor.
- fenfluramine
motherwort increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fluphenazine
fluphenazine and motherwort both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and motherwort both increase sedation. Use Caution/Monitor.
- formoterol
motherwort increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- haloperidol
haloperidol and motherwort both increase sedation. Use Caution/Monitor.
- hydromorphone
hydromorphone and motherwort both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.
- iloperidone
iloperidone and motherwort both increase sedation. Use Caution/Monitor.
- imipramine
imipramine and motherwort both increase sedation. Use Caution/Monitor.
- isoproterenol
motherwort increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketotifen, ophthalmic
ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.
- levalbuterol
motherwort increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
levorphanol and motherwort both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
motherwort increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
lofepramine and motherwort both increase sedation. Use Caution/Monitor.
- lofexidine
lofexidine and motherwort both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and motherwort both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and motherwort both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and motherwort both increase sedation. Use Caution/Monitor.
- loxapine
loxapine and motherwort both increase sedation. Use Caution/Monitor.
- loxapine inhaled
loxapine inhaled and motherwort both increase sedation. Use Caution/Monitor.
- maprotiline
maprotiline and motherwort both increase sedation. Use Caution/Monitor.
- marijuana
marijuana and motherwort both increase sedation. Use Caution/Monitor.
- melatonin
melatonin and motherwort both increase sedation. Use Caution/Monitor.
- meperidine
meperidine and motherwort both increase sedation. Use Caution/Monitor.
- meprobamate
meprobamate and motherwort both increase sedation. Use Caution/Monitor.
- metaproterenol
motherwort increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and motherwort both increase sedation. Use Caution/Monitor.
- methadone
methadone and motherwort both increase sedation. Use Caution/Monitor.
- methamphetamine
motherwort increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and motherwort both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
motherwort increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and motherwort both increase sedation. Use Caution/Monitor.
- midodrine
motherwort increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
mirtazapine and motherwort both increase sedation. Use Caution/Monitor.
- modafinil
motherwort increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
motherwort and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
motherwort and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
nalbuphine and motherwort both increase sedation. Use Caution/Monitor.
- norepinephrine
motherwort increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
nortriptyline and motherwort both increase sedation. Use Caution/Monitor.
- olanzapine
olanzapine and motherwort both increase sedation. Use Caution/Monitor.
- opium tincture
opium tincture and motherwort both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and motherwort both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and motherwort both increase sedation. Use Caution/Monitor.
- oxycodone
oxycodone and motherwort both increase sedation. Use Caution/Monitor.
- oxymorphone
oxymorphone and motherwort both increase sedation. Use Caution/Monitor.
- paliperidone
paliperidone and motherwort both increase sedation. Use Caution/Monitor.
- papaveretum
papaveretum and motherwort both increase sedation. Use Caution/Monitor.
- papaverine
motherwort and papaverine both increase sedation. Use Caution/Monitor.
- pentazocine
pentazocine and motherwort both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and motherwort both increase sedation. Use Caution/Monitor.
- perphenazine
perphenazine and motherwort both increase sedation. Use Caution/Monitor.
- phendimetrazine
motherwort increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and motherwort both increase sedation. Use Caution/Monitor.
- phentermine
motherwort increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
motherwort increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
motherwort increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
motherwort and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
pimozide and motherwort both increase sedation. Use Caution/Monitor.
- pirbuterol
motherwort increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- primidone
primidone and motherwort both increase sedation. Use Caution/Monitor.
- prochlorperazine
prochlorperazine and motherwort both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and motherwort both increase sedation. Use Caution/Monitor.
- propylhexedrine
motherwort increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
protriptyline and motherwort both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and motherwort both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine and motherwort both increase sedation. Use Caution/Monitor.
- ramelteon
motherwort and ramelteon both increase sedation. Use Caution/Monitor.
- risperidone
risperidone and motherwort both increase sedation. Use Caution/Monitor.
- salmeterol
motherwort increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
motherwort and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and motherwort both increase sedation. Use Caution/Monitor.
- shepherd's purse
motherwort and shepherd's purse both increase sedation. Use Caution/Monitor.
- sufentanil
sufentanil and motherwort both increase sedation. Use Caution/Monitor.
- tapentadol
tapentadol and motherwort both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and motherwort both increase sedation. Use Caution/Monitor.
- terbutaline
motherwort increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
thioridazine and motherwort both increase sedation. Use Caution/Monitor.
- thiothixene
thiothixene and motherwort both increase sedation. Use Caution/Monitor.
- topiramate
motherwort and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
tramadol and motherwort both increase sedation. Use Caution/Monitor.
- trazodone
trazodone and motherwort both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and motherwort both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and motherwort both increase sedation. Use Caution/Monitor.
- trifluoperazine
trifluoperazine and motherwort both increase sedation. Use Caution/Monitor.
- trimipramine
trimipramine and motherwort both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and motherwort both increase sedation. Use Caution/Monitor.
- xylometazoline
motherwort increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
motherwort increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
motherwort and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
ziprasidone and motherwort both increase sedation. Use Caution/Monitor.
Minor (2)
- eucalyptus
eucalyptus and motherwort both increase sedation. Minor/Significance Unknown.
- sage
motherwort and sage both increase sedation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Diarrhea
Drowsiness
Stomach problems
Warnings
Contraindications
Pregnancy, thyroid conditions
Cautions
Breastfeeding
Pregnancy & Lactation
Pregnancy Category: avoid
Lactation: use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Emmenagogue: contains chemicals that have effects on uterus, which may result in improved menstrual flow
Cardiac: contains chemicals that have vasorelaxing & cardiotonic effects (digoxin-like)