Motherwort (Herb/Suppl)

Brand and Other Names:leonurus cardiaca, lion's ear, more...lion's tail, throw wort
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Suggested Dosing

Crushed herb: 4.5 g PO q30-60min (acute conditions); TID (chronic)

Other preparations: see mfr's directions

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Suggested Uses

Arrhythmia, low cardiac output, delayed menstruation, metrorrhagia

Efficacy: Insufficient reliable evidence, may improve menstrual flow, has relaxing effect on heart

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Interactions

Interaction Checker

and Motherwort

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      Serious - Use Alternative

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            Contraindicated (0)

              Serious - Use Alternative (2)

              • calcium/magnesium/potassium/sodium oxybates

                motherwort, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • sodium oxybate

                motherwort, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              Monitor Closely (160)

              • albuterol

                motherwort increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • alfentanil

                alfentanil and motherwort both increase sedation. Use Caution/Monitor.

              • alprazolam

                alprazolam and motherwort both increase sedation. Use Caution/Monitor.

              • amitriptyline

                amitriptyline and motherwort both increase sedation. Use Caution/Monitor.

              • amobarbital

                amobarbital and motherwort both increase sedation. Use Caution/Monitor.

              • amoxapine

                amoxapine and motherwort both increase sedation. Use Caution/Monitor.

              • apomorphine

                apomorphine and motherwort both increase sedation. Use Caution/Monitor.

              • arformoterol

                motherwort increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • aripiprazole

                aripiprazole and motherwort both increase sedation. Use Caution/Monitor.

              • armodafinil

                motherwort increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • azelastine

                azelastine and motherwort both increase sedation. Use Caution/Monitor.

              • baclofen

                baclofen and motherwort both increase sedation. Use Caution/Monitor.

              • belladonna and opium

                belladonna and opium and motherwort both increase sedation. Use Caution/Monitor.

              • benperidol

                benperidol and motherwort both increase sedation. Use Caution/Monitor.

              • benzphetamine

                motherwort increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • brompheniramine

                brompheniramine and motherwort both increase sedation. Use Caution/Monitor.

              • buprenorphine

                buprenorphine and motherwort both increase sedation. Use Caution/Monitor.

              • buprenorphine buccal

                buprenorphine buccal and motherwort both increase sedation. Use Caution/Monitor.

              • butabarbital

                butabarbital and motherwort both increase sedation. Use Caution/Monitor.

              • butalbital

                butalbital and motherwort both increase sedation. Use Caution/Monitor.

              • butorphanol

                butorphanol and motherwort both increase sedation. Use Caution/Monitor.

              • caffeine

                motherwort increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • carbinoxamine

                carbinoxamine and motherwort both increase sedation. Use Caution/Monitor.

              • carisoprodol

                carisoprodol and motherwort both increase sedation. Use Caution/Monitor.

              • chloral hydrate

                chloral hydrate and motherwort both increase sedation. Use Caution/Monitor.

              • chlordiazepoxide

                chlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.

              • chlorpheniramine

                chlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.

              • chlorpromazine

                chlorpromazine and motherwort both increase sedation. Use Caution/Monitor.

              • chlorzoxazone

                chlorzoxazone and motherwort both increase sedation. Use Caution/Monitor.

              • cinnarizine

                cinnarizine and motherwort both increase sedation. Use Caution/Monitor.

              • clemastine

                clemastine and motherwort both increase sedation. Use Caution/Monitor.

              • clomipramine

                clomipramine and motherwort both increase sedation. Use Caution/Monitor.

              • clonazepam

                clonazepam and motherwort both increase sedation. Use Caution/Monitor.

              • clorazepate

                clorazepate and motherwort both increase sedation. Use Caution/Monitor.

              • clozapine

                clozapine and motherwort both increase sedation. Use Caution/Monitor.

              • codeine

                codeine and motherwort both increase sedation. Use Caution/Monitor.

              • cyclizine

                cyclizine and motherwort both increase sedation. Use Caution/Monitor.

              • cyclobenzaprine

                cyclobenzaprine and motherwort both increase sedation. Use Caution/Monitor.

              • cyproheptadine

                cyproheptadine and motherwort both increase sedation. Use Caution/Monitor.

              • dantrolene

                dantrolene and motherwort both increase sedation. Use Caution/Monitor.

              • desipramine

                desipramine and motherwort both increase sedation. Use Caution/Monitor.

              • dexchlorpheniramine

                dexchlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.

              • dexfenfluramine

                motherwort increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexmedetomidine

                dexmedetomidine and motherwort both increase sedation. Use Caution/Monitor.

              • dexmethylphenidate

                motherwort increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextroamphetamine

                motherwort increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextromoramide

                dextromoramide and motherwort both increase sedation. Use Caution/Monitor.

              • diamorphine

                diamorphine and motherwort both increase sedation. Use Caution/Monitor.

              • diazepam

                diazepam and motherwort both increase sedation. Use Caution/Monitor.

              • diethylpropion

                motherwort increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • difenoxin hcl

                difenoxin hcl and motherwort both increase sedation. Use Caution/Monitor.

              • dimenhydrinate

                dimenhydrinate and motherwort both increase sedation. Use Caution/Monitor.

              • diphenhydramine

                diphenhydramine and motherwort both increase sedation. Use Caution/Monitor.

              • diphenoxylate hcl

                diphenoxylate hcl and motherwort both increase sedation. Use Caution/Monitor.

              • dipipanone

                dipipanone and motherwort both increase sedation. Use Caution/Monitor.

              • dobutamine

                motherwort increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dopamine

                motherwort increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dopexamine

                motherwort increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • doxepin

                doxepin and motherwort both increase sedation. Use Caution/Monitor.

              • doxylamine

                doxylamine and motherwort both increase sedation. Use Caution/Monitor.

              • droperidol

                droperidol and motherwort both increase sedation. Use Caution/Monitor.

              • ephedrine

                motherwort increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine

                motherwort increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine racemic

                motherwort increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • estazolam

                estazolam and motherwort both increase sedation. Use Caution/Monitor.

              • ethanol

                ethanol and motherwort both increase sedation. Use Caution/Monitor.

              • etomidate

                etomidate and motherwort both increase sedation. Use Caution/Monitor.

              • fenfluramine

                motherwort increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • fluphenazine

                fluphenazine and motherwort both increase sedation. Use Caution/Monitor.

              • flurazepam

                flurazepam and motherwort both increase sedation. Use Caution/Monitor.

              • formoterol

                motherwort increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • haloperidol

                haloperidol and motherwort both increase sedation. Use Caution/Monitor.

              • hydromorphone

                hydromorphone and motherwort both increase sedation. Use Caution/Monitor.

              • hydroxyzine

                hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.

              • iloperidone

                iloperidone and motherwort both increase sedation. Use Caution/Monitor.

              • imipramine

                imipramine and motherwort both increase sedation. Use Caution/Monitor.

              • isoproterenol

                motherwort increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ketotifen, ophthalmic

                ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.

              • levalbuterol

                motherwort increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • levorphanol

                levorphanol and motherwort both increase sedation. Use Caution/Monitor.

              • lisdexamfetamine

                motherwort increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lofepramine

                lofepramine and motherwort both increase sedation. Use Caution/Monitor.

              • lofexidine

                lofexidine and motherwort both increase sedation. Use Caution/Monitor.

              • loprazolam

                loprazolam and motherwort both increase sedation. Use Caution/Monitor.

              • lorazepam

                lorazepam and motherwort both increase sedation. Use Caution/Monitor.

              • lormetazepam

                lormetazepam and motherwort both increase sedation. Use Caution/Monitor.

              • loxapine

                loxapine and motherwort both increase sedation. Use Caution/Monitor.

              • loxapine inhaled

                loxapine inhaled and motherwort both increase sedation. Use Caution/Monitor.

              • maprotiline

                maprotiline and motherwort both increase sedation. Use Caution/Monitor.

              • marijuana

                marijuana and motherwort both increase sedation. Use Caution/Monitor.

              • melatonin

                melatonin and motherwort both increase sedation. Use Caution/Monitor.

              • meperidine

                meperidine and motherwort both increase sedation. Use Caution/Monitor.

              • meprobamate

                meprobamate and motherwort both increase sedation. Use Caution/Monitor.

              • metaproterenol

                motherwort increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • metaxalone

                metaxalone and motherwort both increase sedation. Use Caution/Monitor.

              • methadone

                methadone and motherwort both increase sedation. Use Caution/Monitor.

              • methamphetamine

                motherwort increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • methocarbamol

                methocarbamol and motherwort both increase sedation. Use Caution/Monitor.

              • methylenedioxymethamphetamine

                motherwort increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • midazolam

                midazolam and motherwort both increase sedation. Use Caution/Monitor.

              • midodrine

                motherwort increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • mirtazapine

                mirtazapine and motherwort both increase sedation. Use Caution/Monitor.

              • modafinil

                motherwort increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • morphine

                morphine and motherwort both increase sedation. Use Caution/Monitor.

              • moxonidine

                motherwort and moxonidine both increase sedation. Use Caution/Monitor.

              • nabilone

                motherwort and nabilone both increase sedation. Use Caution/Monitor.

              • nalbuphine

                nalbuphine and motherwort both increase sedation. Use Caution/Monitor.

              • norepinephrine

                motherwort increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nortriptyline

                nortriptyline and motherwort both increase sedation. Use Caution/Monitor.

              • olanzapine

                olanzapine and motherwort both increase sedation. Use Caution/Monitor.

              • opium tincture

                opium tincture and motherwort both increase sedation. Use Caution/Monitor.

              • orphenadrine

                orphenadrine and motherwort both increase sedation. Use Caution/Monitor.

              • oxazepam

                oxazepam and motherwort both increase sedation. Use Caution/Monitor.

              • oxycodone

                oxycodone and motherwort both increase sedation. Use Caution/Monitor.

              • oxymorphone

                oxymorphone and motherwort both increase sedation. Use Caution/Monitor.

              • paliperidone

                paliperidone and motherwort both increase sedation. Use Caution/Monitor.

              • papaveretum

                papaveretum and motherwort both increase sedation. Use Caution/Monitor.

              • papaverine

                motherwort and papaverine both increase sedation. Use Caution/Monitor.

              • pentazocine

                pentazocine and motherwort both increase sedation. Use Caution/Monitor.

              • pentobarbital

                pentobarbital and motherwort both increase sedation. Use Caution/Monitor.

              • perphenazine

                perphenazine and motherwort both increase sedation. Use Caution/Monitor.

              • phendimetrazine

                motherwort increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenobarbital

                phenobarbital and motherwort both increase sedation. Use Caution/Monitor.

              • phentermine

                motherwort increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine

                motherwort increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine PO

                motherwort increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • pholcodine

                motherwort and pholcodine both increase sedation. Use Caution/Monitor.

              • pimozide

                pimozide and motherwort both increase sedation. Use Caution/Monitor.

              • pirbuterol

                motherwort increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • primidone

                primidone and motherwort both increase sedation. Use Caution/Monitor.

              • prochlorperazine

                prochlorperazine and motherwort both increase sedation. Use Caution/Monitor.

              • promethazine

                promethazine and motherwort both increase sedation. Use Caution/Monitor.

              • propylhexedrine

                motherwort increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • protriptyline

                protriptyline and motherwort both increase sedation. Use Caution/Monitor.

              • quazepam

                quazepam and motherwort both increase sedation. Use Caution/Monitor.

              • quetiapine

                quetiapine and motherwort both increase sedation. Use Caution/Monitor.

              • ramelteon

                motherwort and ramelteon both increase sedation. Use Caution/Monitor.

              • risperidone

                risperidone and motherwort both increase sedation. Use Caution/Monitor.

              • salmeterol

                motherwort increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • scullcap

                motherwort and scullcap both increase sedation. Use Caution/Monitor.

              • secobarbital

                secobarbital and motherwort both increase sedation. Use Caution/Monitor.

              • shepherd's purse

                motherwort and shepherd's purse both increase sedation. Use Caution/Monitor.

              • sufentanil

                sufentanil and motherwort both increase sedation. Use Caution/Monitor.

              • tapentadol

                tapentadol and motherwort both increase sedation. Use Caution/Monitor.

              • temazepam

                temazepam and motherwort both increase sedation. Use Caution/Monitor.

              • terbutaline

                motherwort increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • thioridazine

                thioridazine and motherwort both increase sedation. Use Caution/Monitor.

              • thiothixene

                thiothixene and motherwort both increase sedation. Use Caution/Monitor.

              • topiramate

                motherwort and topiramate both increase sedation. Modify Therapy/Monitor Closely.

              • tramadol

                tramadol and motherwort both increase sedation. Use Caution/Monitor.

              • trazodone

                trazodone and motherwort both increase sedation. Use Caution/Monitor.

              • triazolam

                triazolam and motherwort both increase sedation. Use Caution/Monitor.

              • triclofos

                triclofos and motherwort both increase sedation. Use Caution/Monitor.

              • trifluoperazine

                trifluoperazine and motherwort both increase sedation. Use Caution/Monitor.

              • trimipramine

                trimipramine and motherwort both increase sedation. Use Caution/Monitor.

              • triprolidine

                triprolidine and motherwort both increase sedation. Use Caution/Monitor.

              • xylometazoline

                motherwort increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • yohimbine

                motherwort increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ziconotide

                motherwort and ziconotide both increase sedation. Use Caution/Monitor.

              • ziprasidone

                ziprasidone and motherwort both increase sedation. Use Caution/Monitor.

              Minor (2)

              • eucalyptus

                eucalyptus and motherwort both increase sedation. Minor/Significance Unknown.

              • sage

                motherwort and sage both increase sedation. Minor/Significance Unknown.

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              Adverse Effects

              Frequency Not Defined

              Diarrhea

              Drowsiness

              Stomach problems

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              Warnings

              Contraindications

              Pregnancy, thyroid conditions

              Cautions

              Breastfeeding

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              Pregnancy & Lactation

              Pregnancy Category: avoid

              Lactation: use caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Metabolism: N/A

              Excretion: N/A

              Mechanism of Action

              Emmenagogue: contains chemicals that have effects on uterus, which may result in improved menstrual flow

              Cardiac: contains chemicals that have vasorelaxing & cardiotonic effects (digoxin-like)

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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.