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      Drugs & Diseases

      Motherwort (Herb/Suppl)

      Brand and Other Names:leonurus cardiaca, lion's ear, more...lion's tail, throw wort
      • Print

      Suggested Dosing

      Crushed herb: 4.5 g PO q30-60min (acute conditions); TID (chronic)

      Other preparations: see mfr's directions

      Next:

      Suggested Uses

      Arrhythmia, low cardiac output, delayed menstruation, metrorrhagia

      Efficacy: Insufficient reliable evidence, may improve menstrual flow, has relaxing effect on heart

      Previous
      Next:

      Interactions

      Interaction Checker

      and Motherwort

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (2)

                  • calcium/magnesium/potassium/sodium oxybates

                    motherwort, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  • sodium oxybate

                    motherwort, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  Monitor Closely (160)

                  • albuterol

                    motherwort increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • alfentanil

                    alfentanil and motherwort both increase sedation. Use Caution/Monitor.

                  • alprazolam

                    alprazolam and motherwort both increase sedation. Use Caution/Monitor.

                  • amitriptyline

                    amitriptyline and motherwort both increase sedation. Use Caution/Monitor.

                  • amobarbital

                    amobarbital and motherwort both increase sedation. Use Caution/Monitor.

                  • amoxapine

                    amoxapine and motherwort both increase sedation. Use Caution/Monitor.

                  • apomorphine

                    apomorphine and motherwort both increase sedation. Use Caution/Monitor.

                  • arformoterol

                    motherwort increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • aripiprazole

                    aripiprazole and motherwort both increase sedation. Use Caution/Monitor.

                  • armodafinil

                    motherwort increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • azelastine

                    azelastine and motherwort both increase sedation. Use Caution/Monitor.

                  • baclofen

                    baclofen and motherwort both increase sedation. Use Caution/Monitor.

                  • belladonna and opium

                    belladonna and opium and motherwort both increase sedation. Use Caution/Monitor.

                  • benperidol

                    benperidol and motherwort both increase sedation. Use Caution/Monitor.

                  • benzphetamine

                    motherwort increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • brompheniramine

                    brompheniramine and motherwort both increase sedation. Use Caution/Monitor.

                  • buprenorphine

                    buprenorphine and motherwort both increase sedation. Use Caution/Monitor.

                  • buprenorphine buccal

                    buprenorphine buccal and motherwort both increase sedation. Use Caution/Monitor.

                  • butabarbital

                    butabarbital and motherwort both increase sedation. Use Caution/Monitor.

                  • butalbital

                    butalbital and motherwort both increase sedation. Use Caution/Monitor.

                  • butorphanol

                    butorphanol and motherwort both increase sedation. Use Caution/Monitor.

                  • caffeine

                    motherwort increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carbinoxamine

                    carbinoxamine and motherwort both increase sedation. Use Caution/Monitor.

                  • carisoprodol

                    carisoprodol and motherwort both increase sedation. Use Caution/Monitor.

                  • chloral hydrate

                    chloral hydrate and motherwort both increase sedation. Use Caution/Monitor.

                  • chlordiazepoxide

                    chlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.

                  • chlorpheniramine

                    chlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.

                  • chlorpromazine

                    chlorpromazine and motherwort both increase sedation. Use Caution/Monitor.

                  • chlorzoxazone

                    chlorzoxazone and motherwort both increase sedation. Use Caution/Monitor.

                  • cinnarizine

                    cinnarizine and motherwort both increase sedation. Use Caution/Monitor.

                  • clemastine

                    clemastine and motherwort both increase sedation. Use Caution/Monitor.

                  • clomipramine

                    clomipramine and motherwort both increase sedation. Use Caution/Monitor.

                  • clonazepam

                    clonazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • clorazepate

                    clorazepate and motherwort both increase sedation. Use Caution/Monitor.

                  • clozapine

                    clozapine and motherwort both increase sedation. Use Caution/Monitor.

                  • codeine

                    codeine and motherwort both increase sedation. Use Caution/Monitor.

                  • cyclizine

                    cyclizine and motherwort both increase sedation. Use Caution/Monitor.

                  • cyclobenzaprine

                    cyclobenzaprine and motherwort both increase sedation. Use Caution/Monitor.

                  • cyproheptadine

                    cyproheptadine and motherwort both increase sedation. Use Caution/Monitor.

                  • dantrolene

                    dantrolene and motherwort both increase sedation. Use Caution/Monitor.

                  • desipramine

                    desipramine and motherwort both increase sedation. Use Caution/Monitor.

                  • dexchlorpheniramine

                    dexchlorpheniramine and motherwort both increase sedation. Use Caution/Monitor.

                  • dexfenfluramine

                    motherwort increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexmedetomidine

                    dexmedetomidine and motherwort both increase sedation. Use Caution/Monitor.

                  • dexmethylphenidate

                    motherwort increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextroamphetamine

                    motherwort increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextromoramide

                    dextromoramide and motherwort both increase sedation. Use Caution/Monitor.

                  • diamorphine

                    diamorphine and motherwort both increase sedation. Use Caution/Monitor.

                  • diazepam

                    diazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • diethylpropion

                    motherwort increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • difenoxin hcl

                    difenoxin hcl and motherwort both increase sedation. Use Caution/Monitor.

                  • dimenhydrinate

                    dimenhydrinate and motherwort both increase sedation. Use Caution/Monitor.

                  • diphenhydramine

                    diphenhydramine and motherwort both increase sedation. Use Caution/Monitor.

                  • diphenoxylate hcl

                    diphenoxylate hcl and motherwort both increase sedation. Use Caution/Monitor.

                  • dipipanone

                    dipipanone and motherwort both increase sedation. Use Caution/Monitor.

                  • dobutamine

                    motherwort increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopamine

                    motherwort increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopexamine

                    motherwort increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • doxepin

                    doxepin and motherwort both increase sedation. Use Caution/Monitor.

                  • doxylamine

                    doxylamine and motherwort both increase sedation. Use Caution/Monitor.

                  • droperidol

                    droperidol and motherwort both increase sedation. Use Caution/Monitor.

                  • ephedrine

                    motherwort increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine

                    motherwort increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine racemic

                    motherwort increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • estazolam

                    estazolam and motherwort both increase sedation. Use Caution/Monitor.

                  • ethanol

                    ethanol and motherwort both increase sedation. Use Caution/Monitor.

                  • etomidate

                    etomidate and motherwort both increase sedation. Use Caution/Monitor.

                  • fenfluramine

                    motherwort increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fluphenazine

                    fluphenazine and motherwort both increase sedation. Use Caution/Monitor.

                  • flurazepam

                    flurazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • formoterol

                    motherwort increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • haloperidol

                    haloperidol and motherwort both increase sedation. Use Caution/Monitor.

                  • hydromorphone

                    hydromorphone and motherwort both increase sedation. Use Caution/Monitor.

                  • hydroxyzine

                    hydroxyzine and motherwort both increase sedation. Use Caution/Monitor.

                  • iloperidone

                    iloperidone and motherwort both increase sedation. Use Caution/Monitor.

                  • imipramine

                    imipramine and motherwort both increase sedation. Use Caution/Monitor.

                  • isoproterenol

                    motherwort increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ketotifen, ophthalmic

                    ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.

                  • levalbuterol

                    motherwort increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • levorphanol

                    levorphanol and motherwort both increase sedation. Use Caution/Monitor.

                  • lisdexamfetamine

                    motherwort increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lofepramine

                    lofepramine and motherwort both increase sedation. Use Caution/Monitor.

                  • lofexidine

                    lofexidine and motherwort both increase sedation. Use Caution/Monitor.

                  • loprazolam

                    loprazolam and motherwort both increase sedation. Use Caution/Monitor.

                  • lorazepam

                    lorazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • lormetazepam

                    lormetazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • loxapine

                    loxapine and motherwort both increase sedation. Use Caution/Monitor.

                  • loxapine inhaled

                    loxapine inhaled and motherwort both increase sedation. Use Caution/Monitor.

                  • maprotiline

                    maprotiline and motherwort both increase sedation. Use Caution/Monitor.

                  • marijuana

                    marijuana and motherwort both increase sedation. Use Caution/Monitor.

                  • melatonin

                    melatonin and motherwort both increase sedation. Use Caution/Monitor.

                  • meperidine

                    meperidine and motherwort both increase sedation. Use Caution/Monitor.

                  • meprobamate

                    meprobamate and motherwort both increase sedation. Use Caution/Monitor.

                  • metaproterenol

                    motherwort increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • metaxalone

                    metaxalone and motherwort both increase sedation. Use Caution/Monitor.

                  • methadone

                    methadone and motherwort both increase sedation. Use Caution/Monitor.

                  • methamphetamine

                    motherwort increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • methocarbamol

                    methocarbamol and motherwort both increase sedation. Use Caution/Monitor.

                  • methylenedioxymethamphetamine

                    motherwort increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • midazolam

                    midazolam and motherwort both increase sedation. Use Caution/Monitor.

                  • midodrine

                    motherwort increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • mirtazapine

                    mirtazapine and motherwort both increase sedation. Use Caution/Monitor.

                  • modafinil

                    motherwort increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • morphine

                    morphine and motherwort both increase sedation. Use Caution/Monitor.

                  • moxonidine

                    motherwort and moxonidine both increase sedation. Use Caution/Monitor.

                  • nabilone

                    motherwort and nabilone both increase sedation. Use Caution/Monitor.

                  • nalbuphine

                    nalbuphine and motherwort both increase sedation. Use Caution/Monitor.

                  • norepinephrine

                    motherwort increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nortriptyline

                    nortriptyline and motherwort both increase sedation. Use Caution/Monitor.

                  • olanzapine

                    olanzapine and motherwort both increase sedation. Use Caution/Monitor.

                  • opium tincture

                    opium tincture and motherwort both increase sedation. Use Caution/Monitor.

                  • orphenadrine

                    orphenadrine and motherwort both increase sedation. Use Caution/Monitor.

                  • oxazepam

                    oxazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • oxycodone

                    oxycodone and motherwort both increase sedation. Use Caution/Monitor.

                  • oxymorphone

                    oxymorphone and motherwort both increase sedation. Use Caution/Monitor.

                  • paliperidone

                    paliperidone and motherwort both increase sedation. Use Caution/Monitor.

                  • papaveretum

                    papaveretum and motherwort both increase sedation. Use Caution/Monitor.

                  • papaverine

                    motherwort and papaverine both increase sedation. Use Caution/Monitor.

                  • pentazocine

                    pentazocine and motherwort both increase sedation. Use Caution/Monitor.

                  • pentobarbital

                    pentobarbital and motherwort both increase sedation. Use Caution/Monitor.

                  • perphenazine

                    perphenazine and motherwort both increase sedation. Use Caution/Monitor.

                  • phendimetrazine

                    motherwort increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenobarbital

                    phenobarbital and motherwort both increase sedation. Use Caution/Monitor.

                  • phentermine

                    motherwort increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine

                    motherwort increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine PO

                    motherwort increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • pholcodine

                    motherwort and pholcodine both increase sedation. Use Caution/Monitor.

                  • pimozide

                    pimozide and motherwort both increase sedation. Use Caution/Monitor.

                  • pirbuterol

                    motherwort increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • primidone

                    primidone and motherwort both increase sedation. Use Caution/Monitor.

                  • prochlorperazine

                    prochlorperazine and motherwort both increase sedation. Use Caution/Monitor.

                  • promethazine

                    promethazine and motherwort both increase sedation. Use Caution/Monitor.

                  • propylhexedrine

                    motherwort increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • protriptyline

                    protriptyline and motherwort both increase sedation. Use Caution/Monitor.

                  • quazepam

                    quazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • quetiapine

                    quetiapine and motherwort both increase sedation. Use Caution/Monitor.

                  • ramelteon

                    motherwort and ramelteon both increase sedation. Use Caution/Monitor.

                  • risperidone

                    risperidone and motherwort both increase sedation. Use Caution/Monitor.

                  • salmeterol

                    motherwort increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • scullcap

                    motherwort and scullcap both increase sedation. Use Caution/Monitor.

                  • secobarbital

                    secobarbital and motherwort both increase sedation. Use Caution/Monitor.

                  • shepherd's purse

                    motherwort and shepherd's purse both increase sedation. Use Caution/Monitor.

                  • sufentanil

                    sufentanil and motherwort both increase sedation. Use Caution/Monitor.

                  • tapentadol

                    tapentadol and motherwort both increase sedation. Use Caution/Monitor.

                  • temazepam

                    temazepam and motherwort both increase sedation. Use Caution/Monitor.

                  • terbutaline

                    motherwort increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • thioridazine

                    thioridazine and motherwort both increase sedation. Use Caution/Monitor.

                  • thiothixene

                    thiothixene and motherwort both increase sedation. Use Caution/Monitor.

                  • topiramate

                    motherwort and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                  • tramadol

                    tramadol and motherwort both increase sedation. Use Caution/Monitor.

                  • trazodone

                    trazodone and motherwort both increase sedation. Use Caution/Monitor.

                  • triazolam

                    triazolam and motherwort both increase sedation. Use Caution/Monitor.

                  • triclofos

                    triclofos and motherwort both increase sedation. Use Caution/Monitor.

                  • trifluoperazine

                    trifluoperazine and motherwort both increase sedation. Use Caution/Monitor.

                  • trimipramine

                    trimipramine and motherwort both increase sedation. Use Caution/Monitor.

                  • triprolidine

                    triprolidine and motherwort both increase sedation. Use Caution/Monitor.

                  • xylometazoline

                    motherwort increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • yohimbine

                    motherwort increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ziconotide

                    motherwort and ziconotide both increase sedation. Use Caution/Monitor.

                  • ziprasidone

                    ziprasidone and motherwort both increase sedation. Use Caution/Monitor.

                  Minor (2)

                  • eucalyptus

                    eucalyptus and motherwort both increase sedation. Minor/Significance Unknown.

                  • sage

                    motherwort and sage both increase sedation. Minor/Significance Unknown.

                  Previous
                  Next:

                  Adverse Effects

                  Frequency Not Defined

                  Diarrhea

                  Drowsiness

                  Stomach problems

                  Previous
                  Next:

                  Warnings

                  Contraindications

                  Pregnancy, thyroid conditions

                  Cautions

                  Breastfeeding

                  Previous
                  Next:

                  Pregnancy & Lactation

                  Pregnancy Category: avoid

                  Lactation: use caution

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

                  Previous
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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Emmenagogue: contains chemicals that have effects on uterus, which may result in improved menstrual flow

                  Cardiac: contains chemicals that have vasorelaxing & cardiotonic effects (digoxin-like)

                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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