Dosing & Uses
Dosage Forms & Strengths
tablet
- 250mg
Chronic Urinary Tract Infection
Indicated for chronic UTS caused by urea-splitting organisms
Initial: 12 mg/kg/day PO divided q6 -8hr on empty stomach
Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day
Renal Impairment
SCr 1.8-2.5 mg/dL [159-221 micromoles/L]: Dose q12hr; not to exceed 1 g/day
SCr >2.5 mg/dL [>221 micromoles/L]: Not recommended
Dosage Forms & Strengths
tablet
- 250mg
Chronic Urinary Tract Infection
Indicated for chronic UTS caused by urea-splitting organisms
Initial: 10 mg/kg/day PO divided q6-8hr on empty stomach; titrate to patient response
Chronic Urinary Tract Infection
Indicated for chronic UTS caused by urea-splitting organisms
Initial: 12 mg/kg/day PO divided q6-8hr on empty stomach
Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (1)
- sodium picosulfate/magnesium oxide/anhydrous citric acid
acetohydroxamic acid decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.
Minor (6)
- ethanol
acetohydroxamic acid, ethanol. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Temporary rash, flushing.
- ferric maltol
acetohydroxamic acid decreases levels of ferric maltol by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- ferrous fumarate
acetohydroxamic acid decreases levels of ferrous fumarate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- ferrous gluconate
acetohydroxamic acid decreases levels of ferrous gluconate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- ferrous sulfate
acetohydroxamic acid decreases levels of ferrous sulfate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- rose hips
acetohydroxamic acid decreases levels of rose hips by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
Adverse Effects
>10%
Mild headache; first 48 hours (30%)
Anorexia (20-25%)
Malaise (20-25%)
Nausea (20-25%)
Vomiting (20-25%)
Anxiety (20%)
Confused (20%)
Depression (20%)
Involuntary quivering (20%)
Hemolytic anemia (15%)
<1%
Alopecia
Blood clot
Macular rash
Phlebitis
Warnings
Contraindications
Hypersensitivity
Pts. amenable to definitive surgery & antimicrobial agents, infection by non-urease producing organisms, urinary infections controlled by culture-specific antimicrobials, severe renal impairment (CrCl <20 mL/min &/or serum creatinine>2.5 mg/dL [221 umol/L]), inadequate contraception (females), pregnancy
Cautions
Always use with appropriate antimicrobial treatment
Potential teratogen
Pregnancy & Lactation
Pregnancy Category: X
Lactation: excretion in breast milk unknown/not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Inhibits bacterial urease, decreasing ammonia production
Does not acidify urine or have direct antibacterial effect
Pharmacokinetics
Absorption: Well-absorbed
Peak Plasma Time: 15 min -1 hr
Excretion: Urine (55% of oral dose unchanged)
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Lithostat oral - | 250 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
acetohydroxamic acid oral
ACETOHYDROXAMIC ACID - ORAL
(a-SEET-oh-HYE-drox-AM-ik AS-id)
COMMON BRAND NAME(S): Lithostat
USES: This medication is used with antibiotics and/or surgery to treat types of bladder infections that are caused by certain bacteria. These bacteria cause the level of ammonia in the urine to become too high. This effect can lead to a certain type of kidney stone (struvite). This medication works by stopping the bacteria from making the ammonia. The decreased levels of ammonia can slow the growth of the kidney stones and make the antibiotic work better on your infection.
HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using acetohydroxamic acid and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth on an empty stomach as directed by your doctor, usually 3 to 4 times daily.Dosage is based on your medical condition, weight, and response to treatment.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Tell your doctor if your condition lasts or gets worse.
SIDE EFFECTS: Headache, nausea, vomiting, stomach upset, unusual hair loss, or loss of appetite may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fast/pounding heartbeat, unusual tiredness, weakness, dark urine, mental/mood changes (such as nervousness, depression), shaking (tremor), pain/redness/swelling of arms or legs, easy bruising/bleeding, signs of infection (such as sore throat that doesn't go away, fever).Get medical help right away if you have any very serious side effects, including: chest pain.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking acetohydroxamic acid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, blood clots, blood/bone marrow disorders (such as anemia), regular alcohol use.Avoid alcoholic beverages while taking this medication because alcohol with acetohydroxamic acid may cause a skin reaction (such as flushing, redness, warmth, tingling). The reaction usually appears 30 to 45 minutes after having alcohol and disappears 30 to 60 minutes later.This medication must not be used during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.This drug may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: iron-containing products taken by mouth (such as supplements, multivitamins).
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: loss of appetite, weakness, unusual tiredness, nausea, vomiting, shaking (tremor).
NOTES: Do not share this medication with others.Lab and/or medical tests (such as complete blood count, liver/kidney function) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised December 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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