dyphylline (Discontinued)

Brand and Other Names:Dilor (DSC), Lufyllin (DSC)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 200mg
  • 400mg

Asthma/Reversible Bronchospasm

Up to 15 mg/kg PO q6hr PRN  

Reduce in renal impairment

Renal Impairment

CrCl >50 mL/min: Administer 75% of normal dose

CrCl 10-50 mL/min: Administer 50% of normal dose

CrCl < 10 mL/min: Administer 25% of normal dose

Hepatic Impairment

Not studied

Safety & efficacy not established

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Interactions

Interaction Checker

and dyphylline

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Mild & infrequent

            Headache

            Nausea

            Circulatory failure

            Irritability

            Ventricular arrhythmia

            Hypotension

            Tachycardia

            Hyperglycemia

            Muscle twitching

            Albuminuria

            Diuresis

            Hematuria

            Tachypnea

            Restlessness

            Seizure

            Palpitation

            Extrasystoles

            Insomnia

            Upset stomach

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            Warnings

            Contraindications

            Hypersensitivity to dyphylline or other xanthines

            Cautions

            Use caution in severe cardiac disease, HTN, hyperthyroidism, acute myocardial injury, peptic ulcer disease, renal impairment

            Not for status asthmaticus

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excreted in breast milk; use with caution

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Bronchodilator; also exhibits peripheral vasodilatory and bronchial smooth muscle relaxant activity

            Pharmacokinetics

            Peak plasma time: 45 min

            Peak plasma:concentration: 1 g dose: 17 mcg/mL

            Half-Life: 2 hr

            Absorption: Rapid

            Metabolism: not metabolized

            Excretion: Urine (88%)

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            Images

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.