dyphylline (Discontinued)

Brand and Other Names:Dilor (DSC), Lufyllin (DSC)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 200mg
  • 400mg

Asthma/Reversible Bronchospasm

Up to 15 mg/kg PO q6hr PRN  

Reduce in renal impairment

Renal Impairment

CrCl >50 mL/min: Administer 75% of normal dose

CrCl 10-50 mL/min: Administer 50% of normal dose

CrCl < 10 mL/min: Administer 25% of normal dose

Hepatic Impairment

Not studied

Safety & efficacy not established

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Interactions

Interaction Checker

and dyphylline

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • levoketoconazole

                levoketoconazole will increase the level or effect of dyphylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

              Monitor Closely (1)

              • hydrocortisone

                hydrocortisone will decrease the level or effect of dyphylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              Minor (0)

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                Adverse Effects

                Frequency Not Defined

                Mild & infrequent

                Headache

                Nausea

                Circulatory failure

                Irritability

                Ventricular arrhythmia

                Hypotension

                Tachycardia

                Hyperglycemia

                Muscle twitching

                Albuminuria

                Diuresis

                Hematuria

                Tachypnea

                Restlessness

                Seizure

                Palpitation

                Extrasystoles

                Insomnia

                Upset stomach

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                Warnings

                Contraindications

                Hypersensitivity to dyphylline or other xanthines

                Cautions

                Use caution in severe cardiac disease, HTN, hyperthyroidism, acute myocardial injury, peptic ulcer disease, renal impairment

                Not for status asthmaticus

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                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: Excreted in breast milk; use with caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Bronchodilator; also exhibits peripheral vasodilatory and bronchial smooth muscle relaxant activity

                Pharmacokinetics

                Peak plasma time: 45 min

                Peak plasma:concentration: 1 g dose: 17 mcg/mL

                Half-Life: 2 hr

                Absorption: Rapid

                Metabolism: not metabolized

                Excretion: Urine (88%)

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                Images

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                Patient Handout

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.