fluoride (Rx)

Brand and Other Names:Luride, Karidium, more...Fluoritab, Pediaflor, sodium fluoride

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

Strength expressed as fluoride ion

tablet

  • 0.25mg
  • 0.5mg
  • 1mg

oral liquid

  • 0.125mg/drop

tablet, chewable

  • 0.25mg
  • 0.5mg
  • 1mg

lozenge

  • 1mg

Dental Caries Prevention

Intake typically achieved from drinking tap water (community levels vary)

Males adequate intake: 4 mg/day

Females adequate intake: 3 mg/day

Upper limit:10 mg/day

Otosclerosis (Off-label)

20-120 mg sodium fluoride/day divided three times daily PO, usually 20-40 mg/day

Osteoporosis (Off-label)

30-100 mg sodium fluoride /day PO

Dosage Forms & Strengths

Strength expressed as fluoride ion

tablet

  • 0.25mg
  • 0.5mg
  • 1mg

oral liquid

  • 0.125mg/drop

tablet, chewable

  • 0.25mg
  • 0.5mg
  • 1mg

lozenge

  • 1mg

Adequate Intake

Dosing depends on local fluoride content of water supply

Water <0.3 ppm F ion

  • Birth - 6 months: None
  • 6 months - 3 years: 0.25 mg PO qDay
  • 3-6 years: 0.5 mg PO qDay
  • 6-16 years: 1 mg PO qDay

Water 0.3-0.6 ppm F ion

  • Birth - 6 months: None
  • 6 months - 3 years: None
  • 3-6 years: 0.25 mg PO qDay
  • 6-16 years: 0.5 mg PO qDay

Water >0.6 ppm F ion

  • All ages: Supplementation not required

Dose Consideration

Potential toxic dose <6 years: 8 mg/kg

1 ppm = 1 mg fluoride ion

2.2 mg sodium fluoride contains 1 mg fluoride ion

Next:

Interactions

Interaction Checker

and fluoride

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (1)

                  • molybdenum

                    fluoride, molybdenum. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Enhanced dental caries protection.

                  Previous
                  Next:

                  Adverse Effects

                  Frequency Not Defined

                  Nausea

                  Rash

                  Vomiting

                  Discoloration of teeth

                  Previous
                  Next:

                  Warnings

                  Contraindications

                  Hypersensitivity to fluoride, tartrazine, components of the formulation

                  Fluoride content in drinking water >0.7ppm

                  Low sodium or sodium-free diets

                  1 mg tab in < 3 years of age or when drinking water >0.3 ppm

                  1 mg/5 mL rinse in children <6 years of age

                  Previous
                  Next:

                  Pregnancy & Lactation

                  Pregnancy Category: B

                  Lactation: Safe when used in doses below 10 mg per day of elemental fluoride; safe in quantities found in toothpastes, mouth rinses, and fluoride dental treatments

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

                  Previous
                  Next:

                  Pharmacology

                  Mechanism of Action

                  Increases resistance to acid dissolution of the tooth

                  Promotes remineralization of decalcified enamel

                  In dental plaque inhibits cariogenic microbial process

                  Pharmacokinetics

                  Absorption: Rapid and complete; absorption delayed by other soluble fluoride salts, magnesium, calcium, or iron

                  Excretion: Urine and feces

                  Distribution: 50% of fluoride (deposited in teeth and bone after ingestion); topical application works on enamel and plaque superficially

                  Previous
                  Next:

                  Images

                  No images available for this drug.
                  Previous
                  Next:

                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
                  Previous
                  Next:

                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
                  Additional Offers
                  Email to Patient

                  From:

                  To:

                  The recipient will receive more details and instructions to access this offer.

                  By clicking send, you acknowledge that you have permission to email the recipient with this information.

                  Email Forms to Patient

                  From:

                  To:

                  The recipient will receive more details and instructions to access this offer.

                  By clicking send, you acknowledge that you have permission to email the recipient with this information.

                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.