Dosing & Uses
Dosage Forms & Strengths
Strength expressed as fluoride ion
tablet
- 0.25mg
- 0.5mg
- 1mg
oral liquid
- 0.125mg/drop
tablet, chewable
- 0.25mg
- 0.5mg
- 1mg
lozenge
- 1mg
Dental Caries Prevention
Intake typically achieved from drinking tap water (community levels vary)
Males adequate intake: 4 mg/day
Females adequate intake: 3 mg/day
Upper limit:10 mg/day
Otosclerosis (Off-label)
20-120 mg sodium fluoride/day divided three times daily PO, usually 20-40 mg/day
Osteoporosis (Off-label)
30-100 mg sodium fluoride /day PO
Dosage Forms & Strengths
Strength expressed as fluoride ion
tablet
- 0.25mg
- 0.5mg
- 1mg
oral liquid
- 0.125mg/drop
tablet, chewable
- 0.25mg
- 0.5mg
- 1mg
lozenge
- 1mg
Adequate Intake
Dosing depends on local fluoride content of water supply
Water <0.3 ppm F ion
- Birth - 6 months: None
- 6 months - 3 years: 0.25 mg PO qDay
- 3-6 years: 0.5 mg PO qDay
- 6-16 years: 1 mg PO qDay
Water 0.3-0.6 ppm F ion
- Birth - 6 months: None
- 6 months - 3 years: None
- 3-6 years: 0.25 mg PO qDay
- 6-16 years: 0.5 mg PO qDay
Water >0.6 ppm F ion
- All ages: Supplementation not required
Dose Consideration
Potential toxic dose <6 years: 8 mg/kg
1 ppm = 1 mg fluoride ion
2.2 mg sodium fluoride contains 1 mg fluoride ion
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (1)
- molybdenum
fluoride, molybdenum. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Enhanced dental caries protection.
Adverse Effects
Frequency Not Defined
Nausea
Rash
Vomiting
Discoloration of teeth
Warnings
Contraindications
Hypersensitivity to fluoride, tartrazine, components of the formulation
Fluoride content in drinking water >0.7ppm
Low sodium or sodium-free diets
1 mg tab in < 3 years of age or when drinking water >0.3 ppm
1 mg/5 mL rinse in children <6 years of age
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Safe when used in doses below 10 mg per day of elemental fluoride; safe in quantities found in toothpastes, mouth rinses, and fluoride dental treatments
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Increases resistance to acid dissolution of the tooth
Promotes remineralization of decalcified enamel
In dental plaque inhibits cariogenic microbial process
Pharmacokinetics
Absorption: Rapid and complete; absorption delayed by other soluble fluoride salts, magnesium, calcium, or iron
Excretion: Urine and feces
Distribution: 50% of fluoride (deposited in teeth and bone after ingestion); topical application works on enamel and plaque superficially
Images
Formulary
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