Lustra, Neostrata (hydroquinone) dosing, indications, interactions, adverse effects, and more

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Sections hydroquinone
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical cream

topical gel

Reduce Melanin Hyperpigmentation

Apply to affected areas and rub in thoroughly q12hr

Dosage Forms & Strengths

topical cream

topical gel

Reduce Melanin Hyperpigmentation

< 12 years

Safety & efficacy not established

>12 years

Apply to affected areas and rub in thoroughly q12hr

Frequency Not Defined

Mild skin irritation and sensitization (burning, stinging)

Dermatitis

Dryness

Erythema

Inflammatory reaction

Contraindications

Hypersensitivity

Sunburn

Use as depilatory drug

Cautions

Contain sulfites that may cause allergic-type reactions

Avoid unecessary exposure to sunlight

Limit application to areas no larger than arms, hands, face, and neck

Do not apply near eyes, to cut, abraded, or sunburned skin, after shaving or using a depilatory agent; or over miliaria rubra (prickly heat)

Pregnancy & Lactation

Pregnancy Category: C

Lactation: unknown if distributed in breast milk; use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Elicits reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine (DOPA); also suppresses other melanocyte metabolic processes; sun exposure reverses effect and cause repigmentation

Pharmacokinetics

Onset and duration: Varies per individual

Images

Patient Handout

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

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View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections hydroquinone
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

hydroquinone (Rx, OTC)

Dosing & Uses

Dosage Forms & Strengths

topical cream

topical gel

Reduce Melanin Hyperpigmentation

Dosage Forms & Strengths

topical cream

topical gel

Reduce Melanin Hyperpigmentation

< 12 years

>12 years

Adverse Effects

Frequency Not Defined

Warnings

Contraindications

Cautions

Pregnancy & Lactation

Pregnancy Categories

Pharmacology

Mechanism of Action

Pharmacokinetics

Images

Patient Handout

Formulary

Plans

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